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Indian J Pharmacol. 2010 February; 42(1): 55.
PMCID: PMC2885643

Povidone iodine irritant dermatitis

I read the publication by Murthy et al., with a great interest.[1] They reported a case of povidone iodine-induced irritant dermatitis.[1] Indeed, povidone iodine-induced dermatitis is not extremely rare. There are several reports of irritant and allergic dermatitis due to povidone iodine. Severe anaphylaxis due to povidone iodine is also mentioned in literature.[2] Indeed, the differential diagnosis between both conditions is sometimes difficult and needs specific allergic tests.[3] However, in this case report,[3] Murthy et al., did not reach this step. In addition, it should be noted that the irritant condition due to povidone iodine usually relates to an outdated solution.[4] The data on the expired date of povidone iodine should be assessed in every case of povidone iodine dermatitis.


1. Murthy MB, Krishnamurthy B. Severe irritant contact dermatitis induced by povidone iodine solution. Indian J Pharmacol. 2009;41:199–200. [PMC free article] [PubMed]
2. Pedrosa C, Costa H, Oliveira G, Romariz J, Praça F. Anaphylaxis to povidone in a child. Pediatr Allergy Immunol. 2005;16:361–2. [PubMed]
3. Velázquez D, Zamberk P, Suárez R, Lázaro P. Allergic contact dermatitis to povidone-iodine. Contact Dermatitis. 2009;60:348–9. [PubMed]
4. Kara A, Tezer H, Devrim I, Cengiz AB, Secmeer G. Chemical burn: A risk with outdated povidone iodine. Pediatr Dermatol. 2007;24:449–50. [PubMed]

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