Combination of pegylated-interferon (PEG-IFN) plus ribavirin (RBV) is the standard-of-care for hepatitis C virus (HCV) treatment in HIV coinfected individuals. In 2007, abacavir (ABC)-based antiretroviral therapy was for the first time reported to be associated with early virological failure during HCV treatment. The aim of our study was to evaluate the impact of ABC on the response rate to HCV-therapy.
Retrospective analysis of HIV-HCV-coinfected patients treated with PEG-IFN and weight-adjusted RBV in four hospitals in Spain was performed. A descriptive baseline variables analysis was conducted. Logistic regression models were used to test possible associations between non-response and pre-treatment characteristics including antiretroviral drugs.
A total of 244 HIV/HCV co-infected patients treated with pegylated-interferon and ribavirin were included. Eighty-five % of patients were on HAART and of them 24% received ABC-based regimens. The most frequent genotypes were 1 and 3. RBV dosing was ≥13.2 mg/kg/day in 97% of the patients. In the global intent-to-treat analyses, 46.3% of patients reached SVR (46.2% in ABC group vs. 46.7% in non-ABC group, p=1). The only two factors in the multivariate analysis statistically associated with an increased risk of failure to achieve SVR were HCV genotype 1/4 and older age. The use of ABC was not associated with failure to achieve SVR in none of the other time points evaluated.
Our data suggest that the use of ABC-based regimens in the context of HCV therapy does not negatively affects the outcome of this treatment.
Keywords: ABACAVIR, RIBAVIRIN, SVR, HCV treatment