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Logo of annaldermaAnnals of DermatologyThis ArticleInformation for AuthorsOnline Submission
Ann Dermatol. Feb 2009; 21(1): 71–74.
Published online Feb 28, 2009. doi:  10.5021/ad.2009.21.1.71
PMCID: PMC2883376
Angiolymphoid Hyperplasia with Eosinophilia That Was Possibly Induced by Vaccination in a Child
Eun-Kyoung Jeon, M.D., Ah-Young Cho, M.D., Mi-Yoon Kim, M.S., Young Lee, M.D., Young-Joon Seo, M.D., Jang-Kyu Park, M.D., and Jeung-Hoon Lee, M.D.corresponding author
Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea.
corresponding authorCorresponding author.
Reprint request to: Jeung-Hoon Lee, M.D., Department of Dermatology, Chungnam National University Hospital, 640, Daesa-dong, Jung-gu, Daejeon 301-040, Korea. Tel: 82-42-280-7707, Fax: 82-42-280-8459, jhoon/at/
Received June 10, 2008; Accepted July 31, 2008.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign vasoproliferative disease of an unknown cause involving the skin or subcutaneous tissue of the head and neck, and particularly around the ear. It predominantly affects Caucasian adults during the third and fourth decades and it very rarely occurs in children. We experienced a case of ALHE in a 2-year-old Korean boy who had a firm, pruritic, skin-colored, subcutaneous nodule on his right upper arm. The histopathological findings were compatible with ALHE and they showed prominent vascular changes with epitheloid or histiocytoid endothelial cells surrounded by inflammatory cells, including a large proportion of eosinophils. This unusual distribution of the lesion and the young age of the patient may be associated with vaccination.
Keywords: Angiolymphoid hyperplasia with eosinophilia, Child, Vaccination
Articles from Annals of Dermatology are provided here courtesy of
Korean Dermatological Association and Korean Society for Investigative Dermatology