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Logo of annaldermaAnnals of DermatologyThis ArticleInformation for AuthorsOnline Submission
Ann Dermatol. Feb 2009; 21(1): 6–11.
Published online Feb 28, 2009. doi:  10.5021/ad.2009.21.1.6
PMCID: PMC2883372
Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo
Soyun Cho, M.D., Ph.D.,1,2,4 Serah Lee, M.S.,3,4 Min-Jung Lee, M.S.,3,4 Dong Hun Lee, M.D.,2 Chong-Hyun Won, M.D., Ph.D.,1,4 Sang Min Kim, Ph.D.,3,4 and Jin Ho Chung, M.D., Ph.D.corresponding author2,3,4
1Department of Dermatology, Seoul National University Boramae Hospital, Seoul, Korea.
2Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
3Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
4Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Korea.
corresponding authorCorresponding author.
Reprint request to: Jin Ho Chung, M.D., Department of Dermatology, Seoul National University Hospital, 28, Yeongeon-dong, Jongno-gu, Seoul 110-744, Korea. Tel: 82-2-2072-2414, Fax: 82-2-742-7344, jhchung/at/
Received April 21, 2008; Accepted July 20, 2008.
No studies have yet been undertaken to determine the effect of aloe gel on the clinical signs and biochemical changes of aging skin.
We wanted to determine whether dietary aloe vera gel has anti-aging properties on the skin.
Thirty healthy female subjects over the age of 45 were recruited and they received 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days. Their baseline status was used as a control. At baseline and at completion of the study, facial wrinkles were measured using a skin replica, and facial elasticity was measured by an in vivo suction skin elasticity meter. Skin samples were taken before and after aloe intake to compare the type I procollagen and matrix metalloproteinase 1 (MMP-1) mRNA levels by performing real-time RT-PCR.
After aloe gel intake, the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group. In the photoprotected skin, the type I procollagen mRNA levels were increased in both groups, albeit without significance; the MMP-1 mRNA levels were significantly decreased in the higher-dose group. Type I procollagen immunostaining was substantially increased throughout the dermis in both groups.
Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression. However, no dose-response relationship was found between the low-dose and high-dose groups.
Keywords: Aging, Aloe vera, Matrix metalloproteinase, Procollagen, Wrinkles
Articles from Annals of Dermatology are provided here courtesy of
Korean Dermatological Association and Korean Society for Investigative Dermatology