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Logo of annaldermaAnnals of DermatologyThis ArticleInformation for AuthorsOnline Submission
Ann Dermatol. Feb 2009; 21(1): 53–55.
Published online Feb 28, 2009. doi:  10.5021/ad.2009.21.1.53
PMCID: PMC2883370
A Case of Isolated Plexiform Neurofibroma in a Patient with Myasthenia Gravis
Seung Ju Back, M.D., Dae Hun Kim, M.D., Nari Kim, M.S., Young Lee, M.D., Young Joon Seo, M.D., Jang Kyu Park, M.D., and Jeung Hoon Lee, M.D.corresponding author
Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea.
corresponding authorCorresponding author.
Reprint request to: Jeung Hoon Lee, M.D., Department of Dermatology, College of Medicine, Chungnam National University, 640, Daesa-dong, Jung-gu, Daejeon 301-040, Korea. Tel: 82-42-280-7707, Fax: 82-42-280-5098, jhoon/at/
Received June 2, 2008; Accepted July 24, 2008.
We report a case of an isolated plexiform neurofibroma occurring in a patient with myasthenia gravis. A 48-year-old man presented with asymptomatic skin-colored nodules on the tip of his 4th finger. Microscopically, a plexiform neurofibroma was identified located in the dermis that appeared to originate from small superficial nerves. He had a 20-year history of treated myasthenia gravis; otherwise, his personal and family histories were unremarkable. Given that myasthenia gravis is a disorder of the peripheral nerves, plexiform neurofibromas could be associated with myasthenia gravis. However, the development of an isolated plexiform neurofibroma in a case of myasthenia gravis has not yet been reported. The occurrence of a neurofibromas in a patient with myasthenia gravis suggests a link in the pathogenesis of these two diseases.
Keywords: Isolated, Myasthenia gravis, Plexiform neurofibroma
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Korean Dermatological Association and Korean Society for Investigative Dermatology