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Logo of annaldermaThis ArticleThis JournalAboutInformation for AuthorsOnline SubmissionAnnals of Dermatology
Ann Dermatol. 2009 February; 21(1): 53–55.
Published online 2009 February 28. doi:  10.5021/ad.2009.21.1.53
PMCID: PMC2883370

A Case of Isolated Plexiform Neurofibroma in a Patient with Myasthenia Gravis

Seung Ju Back, M.D., Dae Hun Kim, M.D., Nari Kim, M.S., Young Lee, M.D., Young Joon Seo, M.D., Jang Kyu Park, M.D., and Jeung Hoon Lee, M.D.corresponding author


We report a case of an isolated plexiform neurofibroma occurring in a patient with myasthenia gravis. A 48-year-old man presented with asymptomatic skin-colored nodules on the tip of his 4th finger. Microscopically, a plexiform neurofibroma was identified located in the dermis that appeared to originate from small superficial nerves. He had a 20-year history of treated myasthenia gravis; otherwise, his personal and family histories were unremarkable. Given that myasthenia gravis is a disorder of the peripheral nerves, plexiform neurofibromas could be associated with myasthenia gravis. However, the development of an isolated plexiform neurofibroma in a case of myasthenia gravis has not yet been reported. The occurrence of a neurofibromas in a patient with myasthenia gravis suggests a link in the pathogenesis of these two diseases.

Keywords: Isolated, Myasthenia gravis, Plexiform neurofibroma

Articles from Annals of Dermatology are provided here courtesy of Korean Dermatological Association and Korean Society for Investigative Dermatology