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Cardiovasc Dis. 1980 June; 7(2): 169–177.
PMCID: PMC287849

In-vivo sensitivity of canine myocardium to acute depression of serum ionized calcium

Abstract

Recent technologic advances make it possible to measure reliably serum or plasma ionized calcium with a high degree of accuracy. In this study, with the use of 16 mongrel dogs, the quantitation of the hemodynamic response to acute changes in ionized calcium was attempted. It was found that normal cardiac function required a normal level of ionized calcium. In intact animals, severe depression of myocardium is masked by pressor reflexes designed to maintain homeostasis. In their absence, myocardial depression is readily apparent. Animals that are hypercalcemic at the beginning of infusion respond in essentially the same manner. To a degree previously unsuspected, myocardial function depends upon a constant level of ionized calcium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Huxley AF. Muscular contraction. J Physiol. 1974 Nov;243(1):1–43. [PubMed]
  • SEIFEN E, FLACKE W, ALPER MH. EFFECTS OF CALCIUM ON ISOLATED MAMMALIAN HEART. Am J Physiol. 1964 Sep;207:716–720. [PubMed]
  • FEINBERG H, BOYD E, KATZ LN. Calcium effect on performance of the heart. Am J Physiol. 1962 Apr;202:643–648. [PubMed]
  • Gilmore JP, Daggett WM, McDonald RH, Sarnoff SJ. Influence of calcium on myocardial potassium balance, oxygen consumption, and performance. Am Heart J. 1968 Feb;75(2):215–222. [PubMed]
  • Bailey LE, Dresel PE. Correlation of contractile force with a calcium pool in the isolated cat heart. J Gen Physiol. 1968 Dec;52(6):969–982. [PMC free article] [PubMed]
  • BUNKER JP, BENDIXEN HH, MURPHY AJ. Hemodynamic effects of intravenously administered sodium citrate. N Engl J Med. 1962 Feb 22;266:372–377. [PubMed]
  • Cooper N, Brazier JR, Hottenrott C, Mulder DG, Maloney JV, Jr, Buckberg GD. Myocardial depression following citrated blood transfusion. An avoidable complication. Arch Surg. 1973 Nov;107(5):756–763. [PubMed]
  • Corbascio AN, Smith NT. Hemodynamic effects of experimental hypercitremia. Anesthesiology. 1967 May-Jun;28(3):510–516. [PubMed]
  • GOODYER AV, GOODKIND MJ, STANLEY EJ. THE EFFECTS OF ABNORMAL CONCENTRATIONS OF THE SERUM ELECTROLYTES ON LEFT VENTRICULAR FUNCTION IN THE INTACT ANIMAL. Am Heart J. 1964 Jun;67:779–791. [PubMed]
  • Smith NT, Hurley EJ. Citrate infusion in dogs following cardiac autotransplantation. Studies on cardiovascular effects. Arch Surg. 1969 Jan;98(1):44–48. [PubMed]
  • Friedman Z, Hanley WB, Radde IC. Ionized calcium in exchange transfusion with THAM-buffered ACD blood. Can Med Assoc J. 1972 Oct 21;107(8):742–745. [PMC free article] [PubMed]
  • Killen DA, Grogan EL, 2nd, Gower RE, Collins HA. Response of canine plasma-ionized calcium and magnesium to the rapid infusion of acid-citrate-dextrose (ACD) solution. Surgery. 1971 Nov;70(5):736–743. [PubMed]
  • Perkins HA, Snyder M, Thacher C, Rolfs MR. Calcium ion activity during rapid exchange transfusion with citrated blood. Transfusion. 1971 Jul-Aug;11(4):204–212. [PubMed]
  • Killen DA, Grogan EL, Gower RE, Collins IS, Collins HA. Effect of ACD blood prime on plasma calcium and magnesium. Ann Thorac Surg. 1972 Apr;13(4):371–380. [PubMed]
  • Caulfield JB, Zir L, Harthorne JW. Blood calcium levels in the presence of arteriographic contrast material. Circulation. 1975 Jul;52(1):119–123. [PubMed]
  • WALLACE AG, SKINNER NS, Jr, MITCHELL JH. Hemodynamic determinants of the maximal rate of rise of left ventricular pressure. Am J Physiol. 1963 Jul;205:30–36. [PubMed]
  • Bristow MR, Schwartz HD, Binetti G, Harrison DC, Daniels JR. Ionized calcium and the heart. Elucidation of in vivo concentration-response relationships in the open-chest dog. Circ Res. 1977 Oct;41(4):565–574. [PubMed]
  • Bristow MR, Daniels JR, Kernoff RS, Harrison DC. Effect of D600, practolol, and alterations in magnesium on ionized calcium concentration-response relationships in the intact dog heart. Circ Res. 1977 Oct;41(4):574–581. [PubMed]
  • Howland WS, Schweizer O, Carlon GC, Goldiner PL. The cardiovascular effects of low levels of ionized calcium during massive transfusion. Surg Gynecol Obstet. 1977 Oct;145(4):581–586. [PubMed]
  • Dunlop D, Shanks RG. Selective blockade of adrenoceptive beta receptors in the heart. Br J Pharmacol Chemother. 1968 Jan;32(1):201–218. [PubMed]
  • Shinebourne E, White R, Hamer J. A qualitative distinction between the beta-receptor-blocking and local anesthetic actions of antiarrhythmic agents. Circ Res. 1969 Jun;24(6):835–841. [PubMed]
  • Harry JD, Kappagoda CT, Linden RJ, Snow HM. Action of propranolol on the dog heart. Cardiovasc Res. 1973 Nov;7(6):729–739. [PubMed]

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