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The authors of “Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx” (Mol. Biol. Cell  18, 176–188; originally published in MBoC In Press as 10.1091/mbc.E06–01–0014) wish to make a correction. The construct TTKK in Figure 4 of the article should be labeled TTTK, since it encodes a chimeric protein with the extracellular domain and transmembrane domain of ADAM17 (TACE, T) fused to the cytoplasmic domain of ADAM10 (KUZ, K). This correction applies to all results obtained with the TTKK construct in Figure 4B, Figure 6D, and Supplemental Figure 2. Therefore, no conclusions about the requirement of the transmembrane domain of ADAM17 for its response to stimulation with PMA can be drawn from these findings. A corrected Figure 4 is included below. The authors sincerely apologize for any consequences this incorrect labeling might have had for studies based on these results.