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Psychol Med. Author manuscript; available in PMC May 24, 2010.
Published in final edited form as:
PMCID: PMC2874959
NIHMSID: NIHMS199982
Personality traits among ADHD adults: implications of late-onset and subthreshold diagnoses
S. V. Faraone,1* A. Kunwar,1 J. Adamson,2 and J. Biederman2
1Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA
2Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, Boston, MA, USA
*Address for correspondence: Dr S. V. Faraone, Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA. faraones/at/upstate.edu
Background
Diagnosing attention deficit hyperactivity disorder (ADHD) in adults is difficult when diagnosticians cannot establish onset prior to the DSM-IV criterion of age 7 or if the number of symptoms does not achieve the DSM threshold for diagnosis. Previous work has assessed the validity of such diagnoses based on psychiatric co-morbidity, family history and neuropsychological functions but none of these studies have used personality as a validation criterion.
Method
We compared four groups of adults: (1) full ADHD subjects who met all DSM-IV criteria for childhood-onset ADHD; (2) late-onset subjects who met all criteria except the age at onset criterion, (3) subthreshold subjects who did not meet full symptom criteria and (4) non-ADHD subjects who did not meet any of the above criteria. Diagnoses were made by using the Structured Clinical Interview for DSM-IV (SCID) and the Temperament and Character Inventory (TCI) was used to assess personality traits.
Results
We found that full ADHD and late-onset ADHD showed similar personality profiles with significant deviations on all TCI scales except reward dependence and self-transcendence. By contrast, subthreshold cases only showed deviations on novelty seeking and self-directiveness.
Conclusions
These data call into question the stringent age of onset of ADHD symptom criteria for adults when making retrospective diagnoses of ADHD. Subthreshold ADHD seems to be a milder form of the disorder that is consistent with dimensional views of the disorder.
Keywords: Attention deficit hyperactivity disorder (ADHD), diagnosis, personality
Accumulating data suggest that attention deficit hyper-activity disorder (ADHD) persists into adulthood (Faraone et al. 2006a) and is evident in about 4% of adults (Faraone & Biederman, 2005; Kessler et al. 2006). The correlates of ADHD in adulthood are similar to the correlates of ADHD in childhood as regards psychiatric co-morbidity (Barkley et al. 2007), neuropsychological dysfunction (Barkley et al. 2007), treatment response (Faraone et al. 2004a) and genetics (Faraone, 2004). Despite this progress, adult patients with atypical presentations of ADHD or unclear histories of the disorder create difficulties in diagnosis (Adler & Chua, 2002). Such difficulties can lead to low levels of identification and treatment (Faraone, 2000; Faraone et al. 2004b).
In a series of papers (Faraone et al. 2006b, c, 2007b), we examined the validity of two atypical groups: (1) patients meeting all criteria for ADHD except for age at onset and (2) patients having impairing symptoms of ADHD that never exceeded the DSM-IV threshold for diagnosis. This prior work compared subjects without ADHD with those with one of three types of ADHD: (1) full ADHD met all DSM-IV criteria for childhood-onset ADHD; (2) late-onset ADHD met all criteria for age at onset and (3) subthreshold ADHD had subthreshold symptoms only (Faraone et al. 2006b, 2007a, b). We evaluated the validity of these atypical diagnoses based on Robins & Guze's (1970) criteria for the validity of psychiatric diagnoses. In their view, the validity of any disorder derives from a pattern of consistent data. Their validation criteria include clinical correlates, family history, treatment response, laboratory studies, course and outcome. We found that late-onset and full ADHD subjects had similar patterns of psychiatric co-morbidity, neuropsychological impairment, substance use disorders and familial transmission. Subthreshold ADHD was milder and showed a differing pattern of familial transmission. These data suggested that late-onset adult ADHD was valid and that subthreshold ADHD might be a milder form of the disorder.
The present study sought to further assess the validity of late-onset and subthreshold ADHD by evaluating personality traits. Several studies have assessed personality in ADHD. Robin et al. (1998) used the Millon Index of Personality Styles to describe personality profiles of 233 adults with ADHD compared to 50 adults without ADHD. ADHD was associated with most of the personality scales examined. Adults with ADHD had a pessimistic world view, believing that they had little control over their world. They were self-centered, introverted, withdrawn, passive, and more likely to be unconventional and rebellious. They were also less assertive, more yielding, more hesitant in their interactions with others, and more likely to voice their complaints.
May & Bos (2000) used the Millon Clinical Multiaxial Inventory-II (MCMI-II) to study 104 adults with ADHD. They created four groups based on the presence of persisting oppositional defiant disorder (ODD) or other co-morbid diagnoses (ADHD-only, ADHD-co-morbid, ADHD-ODD, ADHD-co-ODD-co-morbid). The ADHD-only group had mild histrionic traits whereas the ADHD-co-morbid group was more often avoidant and dependent. The ADHD-ODD group showed histrionic, narcissistic, aggressive-sadistic and negativistic traits, whereas the ADHD-ODD-co-morbid group had a combination of avoidant, narcissistic, antisocial, aggressive-sadistic, negativistic and self-defeating traits.
Jacob et al. (2007) applied the Revised NEO Personality Inventory (NEO-PI-R) in 372 adults with ADHD and 454 adults without ADHD. Patients with ADHD had higher neuroticism and lower extraversion, openness to experience and conscientiousness. Similar findings were reported in a study that used the NEO-PI-R to compare profiles of 25 adults with ADHD and a control group of 23 non-ADHD adult out-patients being treated with psychotherapy (Ranseen et al. 1998). The ADHD adult group obtained significantly higher scores in the neuroticism domain and significantly lower scores in the conscientiousness domain than the out-patient group.
Several studies applied Cloninger's model of personality to ADHD (Cloninger et al. 1991, 1996; Svrakic et al. 1993). Cloninger's biologically based tridimensional theory of personality initially posited three dimensions of personality: novelty seeking, harm avoidance and reward dependence. He associated high novelty seeking with low dopamine levels and cluster B personality disorders. High harm avoidance was associated with low serotonin levels and cluster C personality disorders, and low reward dependence was associated with low norepinephrine and cluster A personality disorders. The three dimensions were assessed by his Tridimensional Personality Questionnaire (TPQ). These dimensions are moderately heritable and fairly stable throughout the lifespan.
Cloninger later revised the model by referring to the three personality dimensions as temperament. He also added a fourth dimension of temperament (persistence) and three character dimensions for each temperament factor. The dimensions of character are: self-directedness, cooperativeness and self-transcendence. These character dimensions are weakly heritable and are influenced by learning and the family environment. Rather than being stable throughout life, with learning they show a developmental progression. The temperament and character dimensions of the revised model are measured by Cloninger's Temperament and Character Inventory (TCI).
Jacob et al. (2007) found that the novelty seeking and harm avoidance scores of adults with ADHD were significantly elevated on the TPQ. Another study administered the TPQ to three groups of adults: current smokers with ADHD, non-smokers with ADHD, and smokers without ADHD. All groups showed elevations on TPQ novelty seeking and harm avoidance. Smokers with ADHD scored significantly higher than smokers without ADHD (Downey et al. 1996). In a follow-up study, patients with ADHD showed significant elevations for novelty seeking and harm avoidance (Downey et al. 1997). Anckarsater et al. (2006) assessed 240 consecutively referred adults with the TCI and a personality disorder interview. Patients with ADHD reported high novelty seeking, high harm avoidance and more cluster B personality disorders.
Given these findings linking ADHD with personality disorders and traits, an assessment of personality among atypical cases provides another means of assessing the similarity of atypical with gold standard cases. Based on our prior work, we hypothesized that cases of late-onset adult ADHD would show a personality similar to that seen for patients with ADHD meeting full DSM-IV criteria. We further hypothesized that adults with histories of subthreshold impairing symptoms would show a similar personality profile but would be less extreme than the other groups. Following the guidelines of Robins & Guze (1970), a similarity of personality profiles between atypical ADHD and typical ADHD would support the idea that the atypical cases are valid cases of ADHD. By contrast, if the atypical cases showed a distinct personality profile, then that would suggest that some atypical cases of ADHD are individuals with extreme personality traits or disorders.
Subjects
Males and females between the ages of 18 and 55 years were eligible. We excluded potential subjects if they had major sensorimotor handicaps (deafness, blindness), psychosis, inadequate command of the English language, or full-scale IQ <80. Two ascertainment sources provided subjects with ADHD: referrals to Psychiatric Clinics at the Massachusetts General Hospital and advertisements in the greater Boston area. We recruited potential subjects without ADHD through advertisements in the greater Boston area. All subjects provided written informed consent.
Assessment measures
We interviewed all subjects with the Structured Clinical Interview for DSM-IV (SCID; First et al. 1997). Initial diagnoses made by study interviewers were reviewed by a diagnostic committee of board-certified child and adolescent psychiatrists or licensed psychologists. The diagnostic committee was blind to the subject's ascertainment group and all non-diagnostic data. The structured interview data were reviewed by the committee so that they could make a best estimate diagnosis as described by Leckman et al. (1982). Diagnoses were considered definite only if a consensus was achieved that criteria were met to a degree that would be considered clinically meaningful. By 'clinically meaningful' we mean that the data collected from the SCID indicated that the degree of symptoms and impairment reported by the subject was sufficient for the diagnosis to be a clinical concern in the judgment of the clinicians making the best estimate diagnosis.
The TCI is a questionnaire that assesses four dimensions of temperament (novelty seeking, harm avoidance, reward dependence and persistence) and three dimensions of character (self-directedness, cooperativeness and self-transcendence). We administered the TCI-144, a 144-question condensed version of the TCI-295 that uses the 20 best predictors from each personality dimension (Cloninger, 1987; Cloninger et al. 1991; Svrakic et al. 1993).
Statistical analyses
We used log-linear models to analyze differences between groups in TCI subscales; we chose this over linear regression because TCI subscale scores can only take positive integer values. In this case, linear regression would yield biased estimates. We modeled each TCI score as a function of group status (as a nominal variable), age, ethnicity and socio-economic status (SES). For each TCI score considered separately, if the test statistic for the group status variable was significant at the Bonferroni-corrected level of 0.007 (i.e. corrected for the seven tests of group status as a predictor of each TCI scale), we report pairwise group comparisons and discuss these as significant if they attained the Bonferroni-corrected level of 0.008 (i.e. corrected for the six possible pairwise comparisons among the four groups). We also constructed models adjusting for co-morbid mood and anxiety disorders to see if these would account for our findings.
Based on the retrospective reports of ADHD, we classified probands into the following lifetime diagnostic categories: full ADHD met full DSM-IV criteria for ADHD with onset of some symptoms prior to age 7 (n=127). Late-onset ADHD met full DSM-IV criteria for ADHD except for age at onset (n=79). Because we did not place any restrictions on the age at onset for the late-onset group, the range of age at onset was wide (7–45 years); 63% had an age at onset of 7, 8 or 9 years and 83% had onset in the age range 7–12 years. Subthreshold ADHD was defined as never having met DSM-IV criteria for ADHD and reporting a chronic history of three or more inattentive symptoms or three or more hyperactive-impulsive symptoms (n=41). We defined this symptom cut-off based on our previous work (Biederman et al. 2000). The remaining subjects were defined as not ADHD (n=123). The four comparison groups did not differ in gender or marital status (Table 1). Because probands without ADHD were younger and less likely to be Caucasian, all analyses corrected for age and ethnicity.
Table 1
Table 1
Demographic features
Table 2 shows the TCI subscale scores for each group. Late-onset and full ADHD were not significantly different from each other in any TCI dimension. We found no significant differences between subthreshold ADHD and subjects without ADHD in TCI harm avoidance, reward dependence, persistence cooperativeness and self-transcendence. Late-onset and full ADHD had TCI scores significantly different from subjects without ADHD in every dimension except reward dependence and self-transcendance. Subthreshold ADHD had significantly higher TCI novelty-seeking scores than no ADHD; both late-onset and full ADHD had higher TCI novelty-seeking scores than subthreshold ADHD. Late-onset and full ADHD had significantly lower self-directedness scores than subthreshold ADHD.
Table 2
Table 2
TCI scores across four strata of adult ADHD
We found significantly higher TCI harm avoidance scores in late-onset and full ADHD than in subthreshold ADHD. Both late-onset and full ADHD had significantly lower TCI harm avoidance scores than subthreshold ADHD. Full ADHD had significantly lower TCI persistence scores than subthreshold ADHD. Both late-onset and full ADHD had higher TCI self-transcendence scores than subthreshold ADHD.
Table 3 shows the correlations between the TCI dimensions of temperament and character and three classes of ADHD symptoms: inattention, hyperactivity and impulsivity. Except for self-transcendance, each TCI dimension was significantly correlated with each type of ADHD symptom. All findings remained significant after controlling for major depression, bipolar disorder and multiple anxiety disorder (i.e. two or more anxiety disorders).
Table 3
Table 3
Correlations between TCI dimensions and ADHD symptoms
We have examined personality traits to provide further information about the validity of diagnosing ADHD in adults when the onset is late or the numbers of symptoms reported from childhood are subthreshold. As hypothesized, we found that full ADHD and late-onset ADHD showed similar personality profiles with significant deviations on all TCI scales except reward dependence and self-transcendence. By contrast, subthreshold cases only showed deviations on novelty seeking and self-directiveness. Our findings could not be accounted for by differences in psychiatric co-morbidity among subgroups. These data further the notion of the similarities between late-onset ADHD and full ADHD, further calling into question the stringent age at onset criteria for adults when making retrospective diagnoses of ADHD.
Our results regarding age at onset are consistent not only with our prior work described in the introduction (Faraone et al. 2006b, c, 2007b) but also with work from other groups. One study comparing teenagers with onset before or after age 13 found no link between age at onset and severity of symptoms, types of adjustment difficulties or the persistence of ADHD (Schaughency et al. 1994). Rohde et al. (2000) compared clinical features between adolescents meeting full criteria for ADHD and those meeting all criteria except age at onset. Because these two groups had similar profiles of clinical features, the authors concluded that the DSM-IV age at onset criterion should be revised. In an epidemiologically ascertained sample of adolescents, Willoughby et al. (2000) found that adolescents meeting full criteria for combined type ADHD had worse clinical outcomes than those failing to meet the age at onset criterion but found no differences attributable to age at onset for the inattentive subtype of ADHD. In DSM-IV field trials, requiring an age at onset of 7 reduced the accuracy of identifying currently impaired cases of ADHD and reduced agreement with clinician judgments (Applegate et al. 1997).
We were particularly interested in the subthreshold group because our prior work suggested that this group might be heterogeneous, with some cases having an atypical manifestation of ADHD and others not. If, when compared with full ADHD, this group had a qualitatively different set of personality traits, we should have seen a marked difference in their personality profiles. We did not. However, as Table 2 shows, the deviations of the subthreshold group from the non-ADHD group, albeit smaller, are in the same direction as the deviations we observed for late-onset and full ADHD. Our findings for the subthreshold group are consistent with prior papers of ours in which, compared with full ADHD, we found lower rates of familial ADHD (Faraone et al. 2006c), psychiatric co-morbidity (Faraone et al. 2006c), substance use disorders (Faraone et al. 2007b) and neuropsychological dysfunction (Faraone et al. 2006b) for subthreshold subjects. However, in each of these domains, the subthreshold subjects were more impaired than non-ADHD controls. Such data support the idea that ADHD, like blood pressure, is a dimensional trait.
Several other lines of evidence suggest that a dimensional perspective on ADHD is valid. Many studies have found an excellent correspondence between quantitative measures of ADHD (e.g. scales derived from the Child Behavior Checklist, the Conners Scales and the ADHD Rating Scale IV) and the categorical diagnosis (Edelbrock, 1986; Bird et al. 1987; Biederman et al. 1993, 1996; Chen et al. 1994; Boyle et al. 1997; Hudziak, 1997). These studies suggest that children with ADHD are at one extreme of a quantitative dimension and that, on this quantitative dimension, there is no obvious bimodality that separates children with ADHD from other children.
Quantitative measures of ADHD are highly heritable, about 70–90%, which is similar to the heritability of the ADHD diagnosis (Edelbrock et al. 1995; Thapar et al. 1995; Silberg et al. 1996; Judy et al. 1997; Sherman et al. 1997). In fact, twin studies of ADHD have generally applied dimensional rating scales, with clinical cut-offs applied when diagnostic categories were required. These studies all show high heritabilities regardless of where these cut-offs have been made and regardless of whether diagnostic or continuous criteria have been applied (Goodman & Stevenson, 1989a, b; Stevenson, 1992). Twin studies have used mathematical modeling techniques to directly test the hypothesis that the clinical diagnosis of ADHD is the extreme of a quantitative trait. Gjone et al. (1996) applied a mathematical model to determine if the heritability of attention problems increased with their severity. This model is useful because cases at the severe end of the dimension might be expected to have a categorical disorder such as ADHD. If ADHD accounted for the heritability of attention problems we would see increasing heritability with increasing severity. However, heritability did not change with severity, so the authors concluded that there was, in the population, a continuously distributed dimension of genetic liability to attention problems. A similar approach was applied by Levy et al. (1997), who concluded that ADHD was best viewed as the extreme of a behavior that varies genetically throughout the entire population rather than as a categorical disorder. Similar findings were reported by Willcutt et al. (2000). Thus, available data support the idea that ADHD can be viewed as the extreme expression of a trait that varies quantitatively in the population. This, in turn, suggests that personality deviations seen in ADHD can also be viewed from a dimensional perspective.
As Tables 2 and and33 show, ADHD was associated with deviations for each dimension of temperament. Our finding of elevated novelty seeking in ADHD confirms three prior studies of these personality traits in ADHD (Anckarsater et al. 2006; Jacob et al. 2007) and in a sample of smokers with ADHD (Downey et al. 1996). As discussed by Cloninger (1987), individuals high in novelty seeking are quick-tempered, curious, easily bored, impulsive, extravagant, and disorderly. We also found that ADHD was associated with increases in harm avoidance and decreases in reward dependence and persistence. Based on the work of Cloninger and co-workers (Cloninger, 1987; Cloninger et al. 1991; Svrakic et al. 1993), we can interpret these traits as follows. People high in harm avoidance are fearful, socially inhibited, shy, passive, easily tired, and pessimistic even in situations that do not worry other people. Although the higher harm avoidance of ADHD subjects is consistent with ADHD's co-morbidity with anxiety disorders and depression (Biederman et al. 2006; Kessler et al. 2006), the group differences we observed were not accounted for by these disorders, which suggests that this personality subscale may tap subclinical traits. The low persistence scores of adults with ADHD suggest that they tend to give up easily when frustrated, that they are less likely to strive for higher goals, and less likely to persevere at tasks. Low persistence is consistent with the executive functioning deficits seen in many patients with ADHD (Biederman et al. 2007a, b). The low reward dependence seen in patients with ADHD suggests that they are practical, tough-minded, socially insensitive, and indifferent.
Tables 2 and and33 also show that ADHD was associated with TCI character dimensions. Adults with ADHD had increases in self-transcendence and decreases in self-directedness and cooperativeness. The higher self-transcendence seen for adults with ADHD suggests that they tend to be spiritual, unpretentious, humble, and fulfilled. Low self-directedness suggests that adults with ADHD are less responsible, reliable, resourceful, goal-oriented and self-confident and that they find it difficult to define, set and pursue meaningful internal goals. The results from the cooperativeness scale suggest that adults with ADHD show tendencies to being self-absorbed, intolerant, critical, unhelpful, and opportunistic. Such persons tend to be inconsiderate of other people's rights or feelings. These traits are consistent with ADHD's co-morbidities with ODD and conduct disorder.
Our findings should be viewed in light of some limitations. The diagnoses of ADHD relied entirely on the self-report of adult subjects. Although this method allowed us to evaluate the validity of retrospective self-reports, these findings may not generalize to diagnoses defined using data from informants. As Barkley et al. (2002) showed in a study of youth followed into adulthood, informant reports can boost the validity of diagnosing ADHD in adulthood. In addition, because we had relatively few subthreshold subjects, our power to detect differences with this group was limited. Because we did not assess Axis II diagnoses, we cannot draw conclusions about personality disorders in our sample or the relationship between dimensional measures of personality and personality disorders. Because we have relied on retrospective diagnoses, our data cannot discriminate true age at onset effects from recall effects. For example, it is possible that cases of late-onset ADHD are simply patients who could not accurately recall the times when symptoms of ADHD first occurred.
Despite these limitations, these data suggest that, as regards the traits assessed by the TCI, adults with late-onset ADHD are very similar to adults with full ADHD, which provides further support for the idea that the DSM-IV age at onset criterion may be too stringent (Applegate et al. 1997; Barkley & Biederman, 1997; Faraone, 2000; Faraone et al. 2000, 2006b, c, 2007b). In the context of previous reports about psychiatric co-morbidity, family history and neuropsychological functioning and substance use disorders (Faraone et al. 2006b, c, 2007b), our data about personality traits suggest that late-onset ADHD would meet Robins & Guze (1970) criteria for validity. Future research should consider what age of onset would provide the optimal balance for minimizing Type I and Type II diagnostic errors in ADHD. Although our current project did not address what age would provide the most parsimonious criterion, our data do suggest that age 7 may be too stringent. Subthreshold ADHD seems to be a milder form of the disorder. More work is needed to clarify their diagnostic status. Adults with late-onset or full ADHD should be considered for the diagnosis of ADHD with implications for treatment. Although our results have important implications for diagnostic criteria, because nearly all the TCI dimensions were deviant in ADHD cases, they appear to provide an overall index of poor functioning rather than yielding insights into the nature of personality in ADHD patients.
Acknowledgments
This work was supported in part by grants to S.V.F. from the National Institute of Health (R01MH57934).
Footnotes
Declaration of Interest
None.
  • Adler LA, Chua HC. Management of ADHD in adults. Journal of Clinical Psychiatry. 2002;63:29–35. [PubMed]
  • Anckarsater H, Stahlberg O, Larson T, Hakansson C, Jutblad SB, Niklasson L, Nyden A, Wentz E, Westergren S, Cloninger CR, Gillberg C, Rastam M. The impact of ADHD and autism spectrum disorders on temperament, character, and personality development. American Journal of Psychiatry. 2006;163:1239–1244. [PubMed]
  • Applegate B, Lahey B, Hart E, Biederman J, Hynd G, Barkley R, Ollendick T, Frick P, Greenhill L, McBurnett K, Newcorn J, Kerdyk L, Garfinkel B, Waldman I, Shaffer D. Validity of the age of onset criterion for attention-deficit/hyperactivity disorder: a report from the DSM-IV field trials. Journal of the American Academy of Child and Adolescent Psychiatry. 1997;36:1211–1221. [PubMed]
  • Barkley RA, Biederman J. Toward a broader definition of the age-of-onset criterion for attention-deficit hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 1997;36:1204–1210. [PubMed]
  • Barkley RA, Fischer M, Smallish L, Fletcher K. The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder. Journal of Abnormal Psychology. 2002;111:279–289. [PubMed]
  • Barkley RA, Murphy K, Fischer M. The Science of ADHD in Adults: Clinic Referred Adults vs. Children Grown Up. New York, NY: Guilford Press; 2007.
  • Biederman J, Faraone SV, Doyle AE, Lehman BK, Kraus I, Perrin J, Tsuang MT. Convergence of the Child Behavior Checklist with structured interview- based psychiatric diagnoses of ADHD children with and without comorbidity. Journal of Child Psychology and Psychiatry. 1993;34:1241–1251. [PubMed]
  • Biederman J, Faraone SV, Mick E, Moore P, Lelon E. Child Behavior Checklist (CBCL) findings further support comorbidity between ADHD and major depression in a referred sample. Journal of the American Academy of Child and Adolescent Psychiatry. 1996;35:734–742. [PubMed]
  • Biederman J, Mick E, Faraone SV. Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type. American Journal of Psychiatry. 2000;157:816–818. [PubMed]
  • Biederman J, Monuteaux M, Mick E, Spencer T, Wilens T, Silva J, Snyder L, Faraone SV. Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year prospective follow-up study. Psychological Medicine. 2006;36:167–179. [PubMed]
  • Biederman J, Petty C, Fried R, Fontanella J, Doyle AE, Seidman LJ, Faraone SV. Can self-reported behavioral scales assess executive function deficits? A controlled study of adults with ADHD. Journal of Nervous and Mental Disease. 2007a;195:240–246. [PubMed]
  • Biederman J, Petty CR, Fried R, Doyle AE, Spencer T, Seidman LJ, Gross L, Poetzl K, Faraone SV. Stability of executive function deficits into young adult years: a prospective longitudinal follow-up study of grown up males with ADHD. Acta Psychiatrica Scandinavica. 2007b;116:129–136. [PubMed]
  • Bird H, Canino G, Gould M, Ribera J, Rubio-Stipec M, Woodbury M, Huertas-Goldman H, Sesman M. Use of the child behavior checklist as a screening instrument for epidemiological research in child psychiatry: results of a pilot study. Journal of the American Academy of Child and Adolescent Psychiatry. 1987;26:207–213. [PubMed]
  • Boyle M, Offord D, Racine Y, Szatmari P, Sanford M, Fleming J. Adequacy of interviews vs checklists for classifying childhood psychiatric disorder based on parent reports. Archives of General Psychiatry. 1997;54:793–799. [PubMed]
  • Chen W, Faraone S, Biederman J, Tsuang M. Diagnostic accuracy of the Child Behavior Checklist scales for attention deficit hyperactivity disorder: A receiver operating characteristic analysis. Journal of Consulting and Clinical Psychology. 1994;62:1017–1025. [PubMed]
  • Cloninger C, Adolfsson R, Svrakic N. Mapping genes for human personality. Nature Genetics. 1996;12:3–4. [PubMed]
  • Cloninger CR. Neurogenetic adaptive mechanisms in alcoholism. Science. 1987;236:140–416. [PubMed]
  • Cloninger CR, Przybeck TR, Svrakic DM. The tridimensional personality questionnaire: U.S. normative data. Psychological Reports. 1991;69:1047–1057. [PubMed]
  • Downey K, Pomerleau CS, Pomerleau OF. Personality differences related to smoking and adult attention deficit hyperactivity disorder. Journal of Substance Abuse. 1996;8:129–135. [PubMed]
  • Downey K, Stelson F, Pomerleau O, Giordiani B. Adult attention deficit hyperactivity disorder: psychological test profiles in a clinical population. Journal of Nervous and Mental Disease. 1997;185:32–38. [PubMed]
  • Edelbrock C. Behavioral ratings of children diagnosed for attention deficit disorder. Psychiatric Annals. 1986;16:36–40.
  • Edelbrock C, Rende R, Plomin R, Thompson LA. A twin study of competence and problem behavior in childhood and early adolescence. Journal of Child Psychology and Psychiatry. 1995;36:775–785. [PubMed]
  • Faraone S, Biederman J, Mick E. The age-dependent decline of attention-deficit/hyperactivity disorder: a meta-analysis of follow-up studies. Psychological Medicine. 2006a;36:159–165. [PubMed]
  • Faraone SV. Attention deficit hyperactivity disorder in adults: implications for theories of diagnosis. Current Directions in Psychological Science. 2000;9:33–36.
  • Faraone SV. Genetics of adult attention-deficit/hyperactivity disorder. Psychiatric Clinics of North America. 2004;27:303–321. [PubMed]
  • Faraone SV, Biederman J. What is the prevalence of adult ADHD? Results of a population screen of 966 adults. Journal of Attention Disorders. 2005;9:384–391. [PubMed]
  • Faraone SV, Biederman J, Doyle AE, Murray K, Petty C, Adamson J, Seidman L. Neuropsychological studies of late-onset and subthreshold diagnoses of adult ADHD. Biological Psychiatry. 2006b;60:1081–1087. [PubMed]
  • Faraone SV, Biederman J, Spencer T, Wilens T, Seidman LJ, Mick E, Doyle AE. Attention deficit hyperactivity disorder in adults: an overview. Biological Psychiatry. 2000;48:9–20. [PubMed]
  • Faraone SV, Biederman J, Spencer TJ, Mick E, Murray K, Petty C, Adamson JJ, Monuteaux MC. Diagnosing adult attention deficit hyperactivity disorder: are late-onset and subthreshold diagnoses valid? American Journal of Psychiatry. 2006c;163:1720–1729. [PubMed]
  • Faraone SV, Biederman J, Wilens TE, Adamson JJ. A naturalistic study of the effects of pharmacotherapy on substance use disorders among ADHD adults. Psychological Medicine. 2007a;37:1–10. [PubMed]
  • Faraone SV, Spencer T, Aleardi M, Pagano C, Biederman J. Meta-analysis of the efficacy of methylphenidate for treating adult attention deficit hyperactivity disorder. Journal of Clinical Psychopharmacology. 2004a;54:24–29. [PubMed]
  • Faraone SV, Spencer T, Montano CB, Biederman J. Attention deficit hyperactivity disorder in adults: a survey of current practice in psychiatry and primary care. Archives of Internal Medicine. 2004b;164:1221–1226. [PubMed]
  • Faraone SV, Wilens TE, Petty C, Antshel K, Spencer T, Biederman J. Substance use among ADHD adults: implications of late-onset and subthreshold diagnoses. American Journal on Addictions. 2007b;16:24–34. [PubMed]
  • First M, Spitzer R, Gibbon M, Williams J. Structured Clinical Interview for DSM-IV Axis I Disorders. Washington, DC: American Psychiatric Press; 1997.
  • Gjone H, Stevenson J, Sundet J. Genetic influence on parent-reported attention-related problems in a Norwegian general population twin sample. Journal of the American Academy of Child and Adolescent Psychiatry. 1996;35:588–598. [PubMed]
  • Goodman R, Stevenson J. A twin study of hyperactivity: I. An examination of hyperactivity scores and categories derived from Rutter teacher and parent questionnaires. Journal of Child Psychology and Psychiatry. 1989a;30:671–689. [PubMed]
  • Goodman R, Stevenson J. A twin study of hyperactivity: II. The aetiological role of genes, family relationships and perinatal adversity. Journal of Child Psychology and Psychiatry. 1989b;30:691–709. [PubMed]
  • Hudziak JJ. Identification of phenotypes for molecular genetic studies of common childhood psychopathology. In: Blum K, Noble EP, editors. Handbook of Psychiatric Genetics. Boca Raton, FL: CRC Press; 1997. pp. 201–217.
  • Jacob CP, Romanos J, Dempfle A, Heine M, Windemuth-Kieselbach C, Kruse A, Reif A, Walitza S, Romanos M, Strobel A, Brocke B, Schafer H, Schmidtke A, Boning J, Lesch KP. Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center. European Archives of Psychiatry and Clinical Neuroscience. 2007;257:309–317. [PubMed]
  • Judy L, Silberg J, Meyer J, Maes H, Simonoff E, Pickles A, Rutter M, Reynolds C, Heath A, Truett K, Meale M, Erikson M, Loeber R, Hewitt J. Genetics and developmental psychopathology: 2. The main effects of genes and environment of behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. Journal of Child Psychology and Psychiatry. 1997;38:965–980. [PubMed]
  • Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, Faraone SV, Greenhill LL, Howes MJ, Secnik K, Spencer T, Ustun TB, Walters EE, Zaslavsky AM. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. American Journal of Psychiatry. 2006;163:716–723. [PMC free article] [PubMed]
  • Leckman JF, Sholomskas D, Thompson D, Belanger A, Weissman MM. Best estimate of lifetime psychiatric diagnosis: a methodological study. Archives of General Psychiatry. 1982;39:879–883. [PubMed]
  • Levy F, Hay D, McStephen M, Wood C, Waldman I. Attention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a large-scale twin study. Journal of the American Academy of Child and Adolescent Psychiatry. 1997;36:737–744. [PubMed]
  • May B, Bos J. Personality characteristics of ADHD adults assessed with the Millon Clinical Multiaxial Inventory-II: evidence of four distinct subtypes. Journal of Personality Assessment. 2000;75:237–248. [PubMed]
  • Ranseen JD, Campbell DA, Baer RA. NEO PI-R profiles of adults with attention deficit disorder. Assessment. 1998;5:19–24. [PubMed]
  • Robin AJ, Tzelepis A, Bedway M, Gilroy M, Sparague D. The empirical study of personality in ADHD adults: a new beginning. ADHD Report. 1998;5:11–15.
  • Robins E, Guze SB. Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. American Journal of Psychiatry. 1970;126:983–987. [PubMed]
  • Rohde LA, Biederman J, Zimmermann H, Schmitz M, Martins S, Tramontina S. Exploring ADHD age-of-onset criterion in Brazilian adolescents. European Child and Adolescent Psychiatry. 2000;9:212–218. [PubMed]
  • Schaughency E, McGee R, Raja SN, Feehan M, Silva PA. Self reported inattention, impulsivity and hyperactivity at ages 15 and 18 in the general population. Journal of the American Academy of Child and Adolescent Psychiatry. 1994;33:173–184. [PubMed]
  • Sherman D, Iacono W, McGue M. Attention deficit hyperactivity disorder dimensions: a twin study of inattention and impulsivity hyperactivity. Journal of the American Academy of Child and Adolescent Psychiatry. 1997;36:745–753. [PubMed]
  • Silberg J, Rutter M, Meyer J, Maes H, Hewitt J, Simonoff E, Pickles A, Loeber R. Genetic and environmental influences on the covariation between hyperactivity and conduct disturbance in juvenile twins. Journal of Child Psychology and Psychiatry. 1996;37:803–816. [PubMed]
  • Stevenson J. Evidence for a genetic etiology in hyperactivity in children. Behavior Genetics. 1992;22:337–344. [PubMed]
  • Svrakic DM, Whitehead C, Przybeck TR, Cloninger CR. Differential diagnosis of personality disorders by the seven-factor model of temperament and character. Archives of General Psychiatry. 1993;50:991–999. [PubMed]
  • Thapar A, Hervas A, McGuffin P. Childhood hyperactivity scores are highly heritable and show sibling competition effects: twin study evidence. Behavior Genetics. 1995;25:537–544. [PubMed]
  • Willcutt EG, Pennington BF, DeFries JC. Etiology of inattention and hyperactivity/impulsivity in a community sample of twins with learning difficulties. Journal of Abnormal Child Psychology. 2000;28:149–159. [PubMed]
  • Willoughby MT, Curran PJ, Costello EJ, Angold A. Implications of early versus late-onset of attention-deficit/hyperactivity disorder symptoms. Journal of the American Academy of Child and Adolescent Psychiatry. 2000;39:1512–1519. [PubMed]