PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of plosonePLoS OneView this ArticleSubmit to PLoSGet E-mail AlertsContact UsPublic Library of Science (PLoS)
 
PLoS One. 2010; 5(5): e10574.
Published online 2010 May 13. doi:  10.1371/journal.pone.0010574
PMCID: PMC2869349

Cross-National Analysis of the Associations between Traumatic Events and Suicidal Behavior: Findings from the WHO World Mental Health Surveys

Beverley J. Shea, Editor

Abstract

Background

Community and clinical data have suggested there is an association between trauma exposure and suicidal behavior (i.e., suicide ideation, plans and attempts). However, few studies have assessed which traumas are uniquely predictive of: the first onset of suicidal behavior, the progression from suicide ideation to plans and attempts, or the persistence of each form of suicidal behavior over time. Moreover, few data are available on such associations in developing countries. The current study addresses each of these issues.

Methodology/Principal Findings

Data on trauma exposure and subsequent first onset of suicidal behavior were collected via structured interviews conducted in the households of 102,245 (age 18+) respondents from 21 countries participating in the WHO World Mental Health Surveys. Bivariate and multivariate survival models tested the relationship between the type and number of traumatic events and subsequent suicidal behavior. A range of traumatic events are associated with suicidal behavior, with sexual and interpersonal violence consistently showing the strongest effects. There is a dose-response relationship between the number of traumatic events and suicide ideation/attempt; however, there is decay in the strength of the association with more events. Although a range of traumatic events are associated with the onset of suicide ideation, fewer events predict which people with suicide ideation progress to suicide plan and attempt, or the persistence of suicidal behavior over time. Associations generally are consistent across high-, middle-, and low-income countries.

Conclusions/Significance

This study provides more detailed information than previously available on the relationship between traumatic events and suicidal behavior and indicates that this association is fairly consistent across developed and developing countries. These data reinforce the importance of psychological trauma as a major public health problem, and highlight the significance of screening for the presence and accumulation of traumatic exposures as a risk factor for suicide ideation and attempt.

Introduction

Suicidal behavior (i.e, suicide ideation, plans, or attempts) is an important public health problem that results in significant morbidity and mortality and is a major contributor to the global burden of disease [1], [2]. Although most suicide attempts do not result in death, such attempts carry a risk for serious injury, are associated with suffering, and increase the risk for subsequent attempts [3][5]. There is an urgent need for research to better understand risk factors for suicidal behavior [6][8]. Psychiatric disorders are among the strongest predictors of suicidal behavior [9], [10]; however, recent data from the World Mental Health Surveys indicate that 31–57% of suicide attempts are not associated with prior psychiatric disorder [11], highlighting the need to understand what other factors might increase the risk of suicidal behavior. There is growing interest in understanding the environmental and genetic influences on suicidal behavior [12], and recent evidence indicates that environmental factors have a stronger influence on the occurrence of negative psychological outcomes (e.g., depression, suicidal behavior) than do known genetic factors [13]. A particularly important potential environmental contributor to suicidal behavior may be exposure to psychological trauma.

Several studies have reported an association between early childhood abuse and subsequent suicidal behavior [14][16]. However, other recent data suggest that exposure to psychological trauma (whether assaultive or non-assaultive) is not an independent predictor of subsequent suicide attempts outside the context of post traumatic stress disorder [PTSD; 17]. Several additional questions remain about the nature of the putative association between exposure to trauma events and suicidality.

First, few studies have assessed which traumas are uniquely predictive of suicidal behavior and its persistence. Traumas often occur in contexts characterized by significant social disruption, particularly among subjects with early adversity. Multivariate analyses, controlling for the effects of different traumatic events may, however, be able to show that certain traumas have a particularly high association with suicidality. For instance, witnessing violent events is strongly associated with being the victim of a violent event, and it would be useful to test the unique association between each type of event and suicidal behavior. Moreover, it is possible that certain types of events, such as those in which the person is physically assaulted or sexually abused, are more distressing and more strongly associated with subsequent suicidal behavior than non-violent events. However, such distinctions have not been carefully tested in prior research—as very large samples are needed to test these more fine-grained associations between specific types of traumatic events and suicidal behavior.

Second, there are few data on the extent to which traumatic events predict the progression from suicide ideation to plans and attempts. Although exposure to traumatic events may be predictive of suicide ideation, it may not necessarily be useful in predicting which people with suicide ideation go on to make suicide plans and attempts. Recent research has shown that many known risk factors for suicidal behavior such as, the presence of a depressive disorder, predict the onset of suicide ideation, but not which people with ideation go on to make a suicide attempt [11]. Despite its potential clinical importance, this issue has not been well studied. Similarly, virtually no studies have examined predictors of the persistence of suicidal behavior over time (i.e., number of years from the first onset to the most recent occurrence of suicidal behavior). Such information is important for understanding the nature of suicidal behavior and for the purposes of clinical monitoring and risk assessment.

Third, most studies on the association of trauma and suicidality to date have been undertaken in developed, high-income countries. There may be different associations between trauma and suicidality in developing countries, where traumatic events may be more prevalent and of different types than those experienced in developed countries [18]. Indeed, recent work has suggested that PTSD is a stronger predictor of suicide attempts in developing countries (odds ratio = 5.6) than in developed countries (odds ratio = 3.0) [11], which may be reflective of such differences. Accurate information on the risk factors for suicidal behavior in both developed and developing countries is needed for the creation of better screening, prevention, and intervention programs around the globe.

The current study uses data from the WHO World Mental Health Surveys to address each of these issues. This series of coordinated epidemiological surveys was carried out in a broad range of countries, and included a detailed assessment of exposure to psychological traumas, as well as a comprehensive survey of suicidal behavior (i.e., suicide ideation, plans, and attempts) [19]. The aims of the study were to examine the unique associations between psychological trauma and suicidal behavior, and to consider the effects of such trauma on multiple forms of suicidality, in high-, middle-, and low-income countries.

Methods

Respondent samples

The WMH surveys were carried out in 21 countries in: Africa (Nigeria; South Africa), the Americas (Brazil; Colombia; Mexico; United States), Asia and the Pacific (India; Japan; New Zealand; Beijing and Shanghai in the People's Republic of China), Europe (Belgium; Bulgaria; France; Germany; Italy; the Netherlands; Romania; Spain; Ukraine), and the Middle East (Israel; Lebanon). The World Bank [20] classifies Colombia, India, Nigeria, China, and Ukraine as low and lower-middle income countries (hereafter “low income countries”); Brazil, Bulgaria, Lebanon, Mexico, Romania, and South Africa as upper-middle income countries (“middle income countries”); and all other survey countries as high income countries. Respondents were selected in most WMH countries using a stratified multistage clustered-area probability sampling strategy. The total sample size was 102,245 (age 18+), with individual country sample sizes ranging from 2,357 in Romania to 12,790 in New Zealand. The weighted average response rate across all countries was 71.9% (Table 1).

Table 1
WMH sample characteristics by World Bank income categories1.

Procedures

All surveys were conducted face-to-face by trained lay interviewers. Standardized interviewer training procedures, WHO translation protocols for all study materials, and quality control procedures for interviewer and data accuracy that have been consistently employed across all WMH countries are described in more detail elsewhere [21], [22]. All respondents completed a Part I interview that contained core diagnostic assessments, including the assessment of suicidal behavior (except in Israel, Romania, and South Africa where all respondents completed both Part I and Part II). All Part I respondents who met criteria for any disorder and a sub-sample of approximately 25% of the rest of the respondents were administered a Part II interview that assessed potential correlates and disorders of secondary interest (n = 52,824, age 18+). Data were weighted to adjust for this differential sampling of Part II respondents, to adjust for differential probabilities of selection within households, and to match samples to population socio-demographic distributions. Informed consent was obtained before beginning interviews in all countries.

Ethics Statement

Procedures for obtaining informed consent and protecting human subjects were approved and monitored for compliance by the Institutional Review Boards of organizations coordinating surveys in each country based on a template developed by the WMH Data Collection Coordinating Centre. A complete list of the participating IRBs, type of consent obtained, procedures for documenting consent, and incentives offered for participation is available at: http://www.hcp.med.harvard.edu/wmh/ftpdir/nationalsample_Ethics_statement.pdf.

Measures

Traumatic events

Traumatic events were assessed using the WMH version of the WHO Composite International Diagnostic Interview (CIDI) Version 3.0, a fully structured diagnostic interview administered by trained lay interviewers [21], which includes a screen for traumatic events as part of the module for the diagnosis of PTSD. The traumatic events assessed in this module incorporate those from various categories, including: (1) natural and man-made disasters and accidents; (2) combat, war, and refugee experiences; (3) sexual and interpersonal violence; (4) witnessing or perpetrating violence; and (5) death or trauma to a loved one. Each type of event was queried separately. For instance, if a person experienced a natural disaster during which a loved one was killed, they could endorse the experience of both traumatic events. This allowed for an examination of the independent effects of each type of event. Respondent age at the time of occurrence of each event was recorded and traumatic events were treated as time varying covariates in each statistical model except for persistence models, for which traumatic events were observed at the time of each suicide outcome and treated as a constant throughout the respondent's life course. Only traumatic events that occurred temporally prior to each suicidal behavior being examined were tested as predictors in each model.

Suicidal behavior

Suicidal behavior was assessed using the Suicidality Module of the WMH-CIDI [21]. This module includes an assessment of the lifetime occurrence, age-of-onset, and age of most recent episode of suicide ideation (“Have you ever seriously thought about committing suicide?”), plans (“Have you ever made a plan for committing suicide?”), and attempts (“Have you ever attempted suicide?”). Consistent with our goal of examining relationships of mental disorders with a continuum of suicidal behaviors, we considered five dated lifetime history outcomes in a series of nested survival analyses (see below for analysis methods): (1) suicide ideation in the total sample, (2) suicide attempt in the total sample, (3) suicide plan among ideators; (4) suicide attempt among ideators with a plan (‘planned attempt’); and (5) suicide attempt among ideators without a plan (‘unplanned attempt’).

Analysis methods

We examined the associations among temporally prior traumatic events (i.e., time-varying covariates) and subsequent suicidal behaviors using discrete-time survival models with person-year as the unit of analysis [23]. Controls for all models include person-year, country, demographic factors (age, gender, time-varying education, time-varying marriage), interactions between life course (3 dichotomous dummies representing early, middle, and later years in the person's life) and demographic factors, parent psychopathology [24], and childhood adversities [15] (additional details available upon request). Missing values for control variables were estimated using multiple imputation [25]. We estimated survival models that were bivariate (i.e., including only one traumatic event at a time) as well as multivariate (i.e., including all traumatic events simultaneously) in predicting each of the five suicide outcomes. Two types of multivariate models were tested: One including all types of traumatic events simultaneously (multivariate additive), and one including both the type and number of traumatic events experienced by each respondent as dummy variables (multivariate interactive). We also tested the associations between traumatic events and the persistence of suicidal behavior using backward recurrence models [26][28]. Such models use a person-year survival approach; however, instead of predicting a future event, we predicted the most recent episode of the event of interest (e.g., most recent suicide attempt) among those who had ever had an initial event (e.g., first suicide attempt) looking backwards in time from the year of interview. For example, a person who made a suicide attempt for the first time at age 25, for the last time at age 30, and who is currently 32 years-old would have three years in their data file coded: 1 (year 30) and 0, 0 (years 31 and 32). A person who made a suicide attempt for the first time at age 25, never made another attempt, and currently is 32 years-old would have 7 time-since-onset (TSO) person-years in their data file all coded 0. In these models age of onset (AOO) and TSO are statistically controlled and so the models provide an indirect estimate of the persistence of each outcome of interest. Studies comparing the results from backward recurrence models with prospective time-to-next-event survival models indicate that the former provide generally good approximations of the coefficients obtained in the latter [29]. Finally, we calculated population attributable risk proportions (PARPs) to examine the population-level effects of traumatic events on suicidal behavior. PARPs represent the proportion of observed cases of the outcome that would be prevented if specific predictor variables could be eliminated, based on the assumption that the ORs in the model accurately represent causal effects of the predictors.

In all analyses, coefficients and standard errors were exponentiated for ease of interpretation and are reported as odds ratios (ORs) with 95% confidence intervals (CIs). Standard errors were estimated with the Taylor series method [30] using SUDAAN software [31] to adjust for weighting and clustering. Multivariate significance was evaluated with Wald χ2 tests based on design-corrected coefficient variance–covariance matrices. In each analysis, associations between traumatic events and suicide outcomes were adjusted for the possible influence of country differences, sex, age, educational attainment, marriage, parental psychopathology, and childhood adversities. All significance tests were evaluated using .05-level two-sided tests. Given the large sample size and multiple analyses conducted in this study, we focus on the magnitude of observed effects rather than on statistical significance in interpreting the importance of study results.

Results

Traumatic events

Traumatic events were fairly common across each sample, occurring among 2.1–30.5% of respondents in each country. The most commonly reported trauma was the death of a loved one (30.5%), followed by witnessing violence (21.8%). More than 10% of the respondents reported interpersonal violence (18.8%), accidents (17.7%), exposure to war (16.2%), or trauma to a loved one (12.5%). Other traumas were less common and all under the 10% level.

In the pooled sample, lifetime suicide ideation and attempts were reported by 9.6% (or n = 8,126) and 2.8% (or n = 2,778) of respondents, respectively. Among ideators, 34.8% (or n = 3,252) developed a suicide plan, and 55.7% of these respondents (or n = 1,871) made a suicide attempt. Among the ideators (n = 8.126), 65.2% (or n = 4,874) did not make a suicide plan, and, of those without a plan, 15.3% (or n = 907) made an attempt.

Among respondents with a history of suicide attempt, almost one in five (20.9%) reported loss of a loved one, and about one in six (16.0%) reported interpersonal violence. Traumas ranged, however, from 1.2% to 20.9%, and we found roughly comparable patterns for estimates of traumas in the other suicide-related behaviors included. More detailed results reported for each adversity and each type of suicidal behavior after disaggregating for income categories are available upon request.

Bivariate associations of traumatic events with lifetime suicidal behavior

Tabulation of bivariate associations (Table 2) shows that the majority of traumatic events are significantly associated with lifetime suicide ideation and suicide attempt. The ORs are highest for sexual (ORs = 2.2–2.6 [95% confidence interval: 2.0–3.1]) and interpersonal (ORs = 1.8–1.9 [CI: 1.6–2.2]) violence. Among those with suicide ideation, traumas generally are not predictive of suicide plan, planned attempt, or unplanned attempt. A similar pattern of findings holds in high-, middle-, and low-income countries (data available upon request). However, in the cross-national sample, among those with suicide ideation, natural disaster is positively associated with suicide plan (OR = 1.3 [CI: 1.1–1.6]), exposure to war is positively associated with planned attempt (OR = 1.6 [CI: 1.0–2.5]), and sexual violence is positively associated with unplanned attempt (OR = 1.5 [CI: 1.1–2.0]).

Table 2
Bivariate model for associations between traumatic events and suicidal behavior1.

Multivariate associations of traumatic events with lifetime suicidal behavior

After controlling for the effects of other traumatic events, there are fewer significant associations between traumatic events and both suicide ideation and suicide attempt (Table 3). ORs remained highest for sexual violence (ORs = 2.0–2.3 [CI: 1.8–2.7]) and interpersonal violence (ORs = 1.6 [CI: 1.4–1.9]). Disaggregation of the associations between traumatic events and suicide attempts again suggests that they are largely due to traumatic events predicting suicide ideation rather than to the progression from suicide ideation to attempt. A similar pattern of findings is seen in high-, middle-, and low-income countries (data available upon request). Again, in the cross-national sample, among those with suicide ideation, natural disaster is positively associated with suicide plan (OR = 1.3 [CI: 1.0–1.6]), exposure to war is positively associated with planned attempt (OR = 1.7 [CI: 1.1–2.6]), and sexual violence is positively associated with unplanned attempt (OR = 1.5 [CI: 1.1–2.1]).

Table 3
Multivariate model for associations between traumatic events and suicidal behavior1.

Effects of the number of traumatic events

There is a positive relationship between the number of traumatic events experienced and the odds of subsequent suicide ideation and suicide attempt (Table 4). Once again, these associations are largely due to traumatic events predicting suicide ideation, rather than the progression from suicide ideation to suicide plan and attempt. For instance, the ORs for suicide attempt increase from 1.6 (CI: 1.4–1.9) among those with one traumatic event (relative to those with zero events) to 4.3 (CI: 2.8–6.5) among those with six traumatic events.

Table 4
Associations between number of traumatic events and suicidal behavior1.

Multivariate associations between type and number of traumatic events and suicidal behavior

Next we examined an interactive multivariate model that included both type and number of traumatic events in the prediction of subsequent first onset of each type of suicidal behavior (Table 5). The ORs for individual traumas in this model can be interpreted as the relative odds of subsequent suicidal behavior among respondents with a history of one and only one traumatic event versus those with no events (and so are somewhat higher than in Table 3). Similar to the additive multivariate model described above, most types of traumatic events are associated with subsequent suicide ideation and attempts; however, none are associated with a significant increase in the odds of transitioning from ideation to plans or attempt. In this more elaborate model that includes type and number of traumatic events, the ORs for number of events are lower than 1.0 in the prediction of suicide ideation and attempt, indicating the existence of sub-additive effects. That is, as the number of traumatic events increases, the relative odds of suicide ideation and attempt increase at a decreasing rate. In other words, as a person experiences more and more traumatic events, the impact of each additional event lessens in magnitude. These sub-additive effects are not observed consistently in the prediction of suicide plan and attempt among those with suicide ideation. A similar pattern of findings holds in high-, middle-, and low-income countries (data available upon request).

Table 5
Multivariate model for associations between type and number of traumatic events and suicidal behavior1.

Next we tested whether the associations between traumatic events and suicidal behavior are mediated by the presence of mental disorders. Re-estimation of the above models after adjusting for the presence of Axis I mental disorders revealed that the associations between traumatic events and suicidal behavior were largely unchanged. Specifically, the ORs for suicide ideation changed from 1.1–2.3 (CI: 1.0–2.7) in the first model, to 1.1–2.0 (CI: 1.0–2.3) in the adjusted model, whereas the ORs for suicide attempt changed from 1.0–2.9 (CI: 0.7–3.6) to 0.9–2.3 (CI: 0.6–2.8) (detailed results available upon request).

Persistence of suicidal behavior

Results from the backward recurrence analyses indicate that no specific traumatic events are associated with the persistence of suicide ideation or suicide attempts in the bivariate models (Table 6). However, having experienced one traumatic event is associated with persistence of suicide ideation and attempts. In the multivariate model, several types of traumatic events are predictive of the persistence of suicidal behavior, with exposure to accidents and to sexual violence predicting persistence of both suicide ideation and suicide attempt. These associations are invariably due to traumatic events predicting the persistence of suicide ideation rather than attempts per se (data available upon request). This pattern of findings holds true across high-, middle-, and low-income countries (data available upon request).

Table 6
Association between traumatic events and persistence of suicidal behavior1.

Interaction of traumatic events and PTSD

As noted earlier, it has been suggested that the association between traumatic events and suicidal behavior is seen primarily in the context of PTSD [17]. Table 7 shows the interactions between traumatic events and PTSD in predicting suicide ideation and suicide attempt. The relative lack of significant findings suggests that the associations between traumatic events and suicidal behavior do not occur only in the presence of PTSD.

Table 7
Suicidal behavior assessed with interactions between DSM-IV PTSD and individual traumatic events1.

Population attributable risk proportions

Finally, we calculated PARPS to examine the population-level effects of traumatic events on suicidal behavior. Results revealed that, assuming a causal relation between traumatic events and suicidal behavior, the elimination of all traumatic events would lead to a 15.4% reduction in suicide ideation and a 22.1% reduction in suicide attempts (Table 8). Consistent with prior analyses, these effects were due primarily to the association between traumatic events and suicide ideation, as PARPs for plans and attempts among ideators were approximately zero (−1.0% to 0.3%).

Table 8
Total (all countries combined) PARP of trauma among suicidality1.

Discussion

Several limitations of the analyses should be emphasized. First, not all potential traumas are listed in detail in the PTSD module; the residual “other trauma” category may include important traumas such as human rights violations [32]. Similarly, the severity and duration of individual traumas are not assessed. Although we obtained detailed data on trauma exposure, the characteristics of trauma may be important, for example, in predicting the transition from suicide ideation to suicide attempt. Second, data from various parts of the globe may differ in important respects; there were different response rates in different countries, and not all samples are nationally representative. Although we controlled for differential response using post-stratification adjustments, response rates may have been related to trauma exposure or suicidal behavior, limiting the generality of the estimates. Third, it is important to emphasize that assessment of both traumatic events and suicidal behavior is based on retrospective self-report. Although significant attention was paid to questionnaire methodology to maximize respondents' recall and to minimize reporting differences, the data are subject to biases at the level of the individual (e.g., mood-congruent recall bias), and of the cultural context (e.g., different cultural contexts may have influenced responses to questions about trauma and suicide in different ways across the surveys) [33][36].

Nevertheless, these data provide a more fine-grained analysis of the relationship between traumatic events and suicidal behavior than has previously been possible, and in doing so extend previous data from community and clinical studies [14], [17], [37][39]. Our main findings were that: (1) in multivariate models there is a particularly strong association between sexual and interpersonal violence and suicide ideation/attempt; (2) there is a dose-response relationship between the number of traumatic events experienced and the subsequent odds of suicide ideation/attempt, but the effects are subadditive with a decay in the strength of the association with more events; (3) although specific traumatic events are useful in predicting suicide ideation, they are generally less useful in predicting the progression from suicide ideation to attempt; and (4) the general pattern of findings holds true across high-, middle-, and low-income countries, regardless of the presence of PTSD, and are not mediated by the presence of mental disorders.

Previous work has emphasized the relationship between exposure to sexual and interpersonal violence and suicidality [16], [40][43]. A range of different mechanisms may account for the specificity of these associations. Disruptions in interpersonal and social bonds (both current and future), for example, may play a key role in precipitating suicide in those who are most vulnerable. Exposure to sexual and interpersonal violence are associated (as are other traumas) with psychiatric disorders such as depression and PTSD, but also (perhaps more specifically than certain other traumas) with increased impulsivity [44], which may play a key role in stress-diathesis models of suicide [11], [14], [16], [41], [45]. The finding that many other traumas are associated with suicidal behavior in bivariate but not multivariate models underscores the complexity of the associations between traumatic events and suicidal behavior. This pattern of findings suggests that some types of traumatic events may be associated with suicidal behavior only because they co-occur with other events that are themselves uniquely associated with suicidal outcomes. For instance, being the perpetrator of violence against others is associated with a subsequent suicide attempt in the bivariate, but not multivariate, analysis, and this may be because the association between these two variables is explained by witnessing violence (even when one is the perpetrator). An alternative hypothesis is that the associations between traumatic events and suicidal behavior are explained by some element common to all such events so that when all are included in a model simultaneously, the unique contribution of each type of event is substantially diminished. However, the fact that most events remained significantly associated with suicide attempt in the multivariate model suggests that this cannot fully explain the observed associations.

The data here are also useful in demonstrating that although more traumatic events are associated with increased suicidal behavior, this influence increases at a decreasing rate—perhaps due in part to habituation. These findings are consistent with a stress-diathesis theory of suicide in which trauma initiates a stress response with biological and psychological consequences (e.g., increased distress or hopelessness) and in which multiple traumas increase the strength of the stress response, but with other factors playing a role in predisposing one to suicide ideation and attempt. We found that certain kinds of trauma, such as accidents and sexual violence, are predictive of the persistence of suicide ideation/attempts; stress-diathesis models of suicidal behavior need further elaboration in order to address the complexities of severity and timing of both risk factors and suicide outcomes.

The data here also indicate that the association between traumatic events and suicide attempt is largely due to traumatic events predicting suicide ideation rather than to the progression from suicide ideation to attempt. Nevertheless, in the cross-national sample, among those with suicide ideation, natural disaster is associated with suicide plan, exposure to war is associated with planned attempt, and sexual violence is associated with unplanned attempt. These data are to some extent consistent with current knowledge of the different kinds of psychopathology that follow different traumatic events; exposure to natural disasters and war may lead to phenomena such as survivor guilt and planned suicide, while exposure to sexual violence may be associated with a range of more impulsive psychopathology [44], [46]. On balance, this pattern was not observed consistently across high-, middle-, and low-income countries, suggesting that these particular associations should be interpreted with some caution until they are shown to replicate across individual countries and/or studies.

Despite this lack of consistency in the risk factors for transitions from suicide ideation to suicide plan and attempt, it is notable that the observed risk factors for suicide ideation and attempt more generally were quite similar across high-, middle-, and low-income countries. This is consistent with growing research on the risk factors for suicidal behavior, many of which cut across a range of different contexts [11]. For example, while prevalence of both psychiatric disorders and suicidal behavior differs across countries, the associations between disorders and suicidal behavior are quite consistent cross-nationally [11]. The consistent pattern of results across different regions of the globe provides significant support for the validity of the associations documented here, despite the limitations noted earlier.

In contrast to the previous work by Wilcox and colleagues [17], we found that the relationships between traumatic events and suicidal behavior held irrespective of whether or not PTSD was present. That study was, however, limited to a young sample of urban African American adults. The findings here are consistent with a view that the mechanisms underlying the relationship between trauma exposure and suicidality are multiple, and may not be explicable on the basis of any single psychiatric entity, or even by psychiatric disorders more generally. Further work is needed to explore in detail the interactions between childhood-onset adversities, adult-onset traumas, and different Axis I and II disorders in the prediction of suicidal behavior [47].

The findings here have potentially important implications not only for mental health policy but also for clinical assessment and intervention. From a policy perspective, there is increasing awareness of violence and other traumas as a major public health problem [48], requiring robust multi-sectoral intervention across the globe. Prevention of traumas, particularly sexual and interpersonal violence, may ultimately result in a significantly reduced burden of psychiatric disorder, including suicide ideation and attempts. In the clinic, it would seem crucial to routinely assess patients for exposure to trauma, including multiple traumas, particularly when there is evidence of psychopathology, including suicide ideation or suicide attempts. Although the results of this study suggest that completely eliminating traumatic events would lead to at most a 22.1% reduction in suicide attempts, future research should examine whether clinical and policy interventions aimed at decreasing the occurrence and impact of traumatic events are effective in decreasing suicidal behavior.

Footnotes

Competing Interests: Dr. Stein has received research grants and/or consultancy honoraria from Astrazeneca, Eli Lilly, GlaxoSmithKline, Jazz Pharmaceuticals, Johnson & Johnson, Lundbeck, Orion, Pfizer, Pharmacia, Roche, Servier, Solvay, Sumitomo, Takeda, Tikvah, and Wyeth. Dr. Kessler has been a consultant for GlaxoSmithKline, Kaiser Permanente, Pfizer, Sanofi-Aventis, Shire Pharmaceuticals, and Wyeth-Ayerst; has served on advisory boards for Eli Lilly and Company and Wyeth-Ayerst; and has had research support for his epidemiological studies from Bristol-Myers Squibb, Eli Lilly and Company, GlaxoSmithKline, Johnson & Johnson Pharmaceuticals, Ortho-McNeil Pharmaceuticals, Pfizer, and Sanofi-Aventis. These competing interest statements do not alter the authors' adherence to the PLoS ONE policies on sharing data and materials.

Funding: This report was carried out in conjunction with the World Health Organization World Mental Health (WMH) Survey Initiative. The authors thank the WMH staff for assistance with instrumentation, fieldwork, and data analysis. These activities were supported by the United States National Institute of Mental Health (R01MH070884, R01MH077883), the John D. and Catherine T. MacArthur Foundation, the Pfizer Foundation, the US Public Health Service (R13-MH066849, R01-MH069864, and R01 DA016558), the Fogarty International Center (FIRCA R03-TW006481), the Pan American Health Organization, the Eli Lilly and Company Foundation, Ortho-McNeil Pharmaceutical, Inc., GlaxoSmithKline, and Bristol-Myers Squibb. A complete list of WMH publications can be found at http://www.hcp.med.harvard.edu/wmh/. The São Paulo Megacity Mental Health Survey is supported by the State of São Paulo Research Foundation (FAPESP) Thematic Project Grant 03/00204-3. The Bulgarian Epidemiological Study of common mental disorders (EPIBUL) is supported by the Ministry of Health and the National Center for Public Health Protection. The Chinese World Mental Health Survey Initiative is supported by the Pfizer Foundation. The Shenzhen Mental Health Survey is supported by the Shenzhen Bureau of Health and the Shenzhen Bureau of Science, Technology, and Information. The Colombian National Study of Mental Health (NSMH) is supported by the Ministry of Social Protection. The ESEMeD project is funded by the European Commission (Contracts QLG5-1999-01042; SANCO 2004123), the Piedmont Region (Italy), Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spain (FIS 00/0028), Ministerio de Ciencia y Tecnología, Spain (SAF 2000-158-CE), Departament de Salut, Generalitat de Catalunya, Spain, Instituto de Salud Carlos III (CIBER CB06/02/0046, RETICS RD06/0011 REM-TAP), and other local agencies and by an unrestricted educational grant from GlaxoSmithKline. The WMHI was funded by WHO (India) and helped by Dr. R. Chandrasekaran, JIPMER. The Israel National Health Survey is funded by the Ministry of Health with support from the Israel National Institute for Health Policy and Health Services Research and the National Insurance Institute of Israel. The World Mental Health Japan (WMHJ) Survey is supported by the Grant for Research on Psychiatric and Neurological Diseases and Mental Health (H13-SHOGAI-023, H14-TOKUBETSU-026, H16-KOKORO-013) from the Japan Ministry of Health, Labour and Welfare. The Lebanese National Mental Health Survey (LEBANON) is supported by the Lebanese Ministry of Public Health, the WHO (Lebanon), Fogarty International, anonymous private donations to IDRAAC, Lebanon, and unrestricted grants from Janssen Cilag, Eli Lilly, GlaxoSmithKline, Roche, and Novartis. The Mexican National Comorbidity Survey (MNCS) is supported by The National Institute of Psychiatry Ramon de la Fuente (INPRFMDIES 4280) and by the National Council on Science and Technology (CONACyT-G30544- H), with supplemental support from the PanAmerican Health Organization (PAHO). Te Rau Hinengaro: The New Zealand Mental Health Survey (NZMHS) is supported by the New Zealand Ministry of Health, Alcohol Advisory Council, and the Health Research Council. The Nigerian Survey of Mental Health and Wellbeing (NSMHW) is supported by the WHO (Geneva), the WHO (Nigeria), and the Federal Ministry of Health, Abuja, Nigeria. The Romania WMH study projects “Policies in Mental Health Area” and “National Study regarding Mental Health and Services Use” were carried out by National School of Public Health and Health Services Management (former National Institute for Research and Development in Health), with technical support of Metro Media Transilvania, the National Institute of Statistics-National Centre for Training in Statistics, SC. Cheyenne Services SRL, Statistics Netherlands and were funded by Ministry of Public Health (former Ministry of Health) with supplemental support of Eli Lilly Roman.

References

1. Nock MK, Borges G, Bromet EJ, Cha CB, Kessler RC, et al. Suicide and suicidal behavior. Epidemiol Rev. 2008;30:133–154. [PMC free article] [PubMed]
2. Lopez AD, Mathers CD, Ezzati M, Jamiso DT, Murray CJL. New York: Oxford University Press and The World Bank; 2006. Global Burden of Disease and Risk Factors.
3. Fawcett J, Scheftner WA, Fogg L, Clark DC, Young MA, et al. Time-related predictors of suicide in major affective disorder. Am J Psychiatry. 1990;147:1189–1194. [PubMed]
4. Neeleman J, de Graaf R, Vollebergh W. The suicidal process: Prospective comparison between early and later stages. J Affect Disord. 2004;82:43–52. [PubMed]
5. Schmidtke A, Bille-Brahe U, DeLeo D, Kerkhof A, Bjerke T, et al. Attempted suicide in Europe: Rates, trends and sociodemographic characteristics of suicide attempters during the period 1989-1992. Results of the WHO/EURO Multicentre Study on Parasuicide. Acta Psychiatr Scand. 1996;93:327–338. [PubMed]
6. WHO. Geneva: World Health Organization; 1996. Prevention of suicide: Guidelines for the formulation and implementation of national strategies.
7. USPH S. The Surgeon General's call to action to prevent suicide. 1999. Washington, DC.
8. USDoHaH S. Washington, DC: Department of Health and Human Services; 2000. Health People 2010, 2nd ed. With Understanding and Improving Health and Objectives for Improving Health (2 vols.).
9. Harris EC, Barraclough B. Suicide as an outcome for mental disorders: A meta-analysis. Br J Psychiatry. 1997;170:205–228. [PubMed]
10. Nock MK, Borges G, Bromet EJ, Alonso J, Angermeyer M, et al. Cross-national prevalence and risk factors for suicidal ideation, plans and attempts. Br J Psychiatry. 2008;192:98–105. [PMC free article] [PubMed]
11. Nock MK, Hwang I, Sampson NA, Kessler RC, Angermeyer M, et al. Cross-national analysis of the associations among mental disorders and suicidal behavior: Findings from the WHO World Mental Health Surveys. PLoS Medicine 2009 [PMC free article] [PubMed]
12. Roy A, Hu X-Z, Janal MN, Goldman D. Interaction between childhood trauma and serotonin transporter gene variation in suicide. Neuropsychopharmacology. 2007;32:2046–2052. [PubMed]
13. Risch N, Herrell R, Lehner T, Liang KY, Eaves L, et al. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. JAMA. 2009;301:2462–2471. [PMC free article] [PubMed]
14. Brodsky BS, Stanley B. Adverse childhood experiences and suicidal behavior. Psychiatr Clin North Am. 2008;31:223–235. [PubMed]
15. Bruffaerts R, Demyttenaere K, Borges G, Haro JM, Chiu WT. Childhood adversities as risk factors for onset and persistence of suicidal behaviour. British Journal of Psychiatry. In press. [PMC free article] [PubMed]
16. Dube SR, Anda RF, Felitti VJ, Chapman DP, Williamson DF, et al. Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: Findings from the Adverse Childhood Experiences Study. JAMA. 2001;286:3089–3096. [PubMed]
17. Wilcox HC, Storr CL, Breslau N. Posttraumatic stress disorder and suicide attempts in a community sample of urban American young adults. Arch Gen Psychiatry. 2009;66:305–311. [PubMed]
18. Williams SL, Williams DR, Stein DJ, Seedat S, Jackson PB, et al. Multiple traumatic events and psychological distress: The South Africa stress and health study. J Trauma Stress. 2007;20:845–855. [PMC free article] [PubMed]
19. Kessler RC, Haro JM, Heeringa SG, Pennell BE, Ustün TB. The World Health Organization World Mental Health Survey Initiative: Epidemiologia e Psichiatria Sociale. An International Journal for Epidemiology and Psychiatric Sciences. 2006;15:161–166. [PubMed]
20. World Bank. Data and Statistics. 2008. World Bank.
21. Kessler RC, Ustun TB. The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res. 2004;13:93–121. [PubMed]
22. Kessler RC, Ustun TB. New York: Cambridge University Press; 2008. The WHO World Mental Health Surveys: Global perspectives on the epidemiology of mental disorders.
23. Efron B. Logistic regression, survival analysis, and the Kaplan Meier curve. Journal of the American Sociological Association. 1988;83:414–425.
24. Gureje O, Oladeji B, Borges G, Bruffaerts R, Haro J. Parental psychopathology and the risk of suicidal behaviour in their offspring: Results from the WHO World Mental Health Surveys. 2010. Manuscript submitted for publication.
25. Rubin DB. Multiple imputation after 18 years. J Am Stat Assoc. 1996;91:473–489.
26. Allison PD. Survival analysis of backward recurrence times. Journal of the American Statistical Association. 1984;80:315–322.
27. Yamaguchi K. Accelerated failure-time mover-stayer regression models for the analysis of last episode data. Sociological Methodology. 2003;33:81–110.
28. McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavksy AM, et al. Childhood adversities and adult psychopathology in the National Comorbidity Survey Replication (NCS-R): Associations with persistence of DSM-IV disorders. Archives of General Psychiatry. 2010;67:124–132. [PMC free article] [PubMed]
29. van Es B, Klaassen CAJ, Oudshoorn K. Survival analysis under cross-sectional sampling: Length bias and multiplicative censoring. Journal of Statistical Planning and Inference. 2000;91:295–312.
30. Wolter KM. New York, NY: Springer-Verlag; 1985. Introduction to variance estimation.
31. SUDAAN 9.0.2. Research Triangle Park, NC: Research Triangle Institute; 2005. Professional Software for Survey Data Analysis [computer program].
32. Stein DJ, Williams SL, Jackson PB, Seedat S, Myer L, et al. Perpetration of gross human rights violations in South Africa: Association with psychiatric disorders. S Afr Med J. 2009;99:390–395. [PMC free article] [PubMed]
33. Alonso J, Buron A, Bruffaerts R, He Y, Posada-Villa J, et al. Association of perceived stigma and mood and anxiety disorders: Results from the World Mental Health Surveys. Acta Psychiatr Scand. 2008;118:305–314. [PMC free article] [PubMed]
34. Lopez SR, Guarnaccia PJ. Cultural psychopathology: Uncovering the social world of mental illness. Annu Rev Psychol. 2000;51:571–598. [PubMed]
35. Schacter DL. The seven sins of memory. Insights from psychology and cognitive neuroscience. Am Psychol. 1999;54:182–203. [PubMed]
36. Schraedley PK, Turner RJ, Gotlib IH. Stability of retrospective reports in depression: Traumatic events, past depressive episodes, and parental psychopathology. J Health Soc Behav. 2002;43:307–316. [PubMed]
37. Santa Mina EE, Gallop RM. Childhood sexual and physical abuse and adult self-harm and suicidal behaviour: A literature review. Can J Psychiatry. 1998;43:793–800. [PubMed]
38. Wiederman MW, Sansone RA, Sansone LA. History of trauma and attempted suicide among women in a primary care setting. Violence Vict. 1998;13:3–9. [PubMed]
39. Tiet QQ, Finney JW, Moos RH. Recent sexual abuse, physical abuse, and suicide attempts among male veterans seeking psychiatric treatment. Psychiatr Serv. 2006;57:107–113. [PubMed]
40. Brent DA, Baugher M, Bridge J, Chen T, Chiappetta L. Age- and sex-related risk factors for adolescent suicide. J Am Acad Child Adolesc Psychiatry. 1999;38:1497–1505. [PubMed]
41. Brodsky BS, Oquendo M, Ellis SP, Haas GL, Malone KM, et al. The relationship of childhood abuse to impulsivity and suicidal behavior in adults with major depression. Am J Psychiatry. 2001;158:1871–1877. [PubMed]
42. Brown J, Cohen P, Johnson JG, Smailes EM. Childhood abuse and neglect: Specificity of effects on adolescent and young adult depression and suicidality. J Am Acad Child Adolesc Psychiatry. 1999;38:1490–1496. [PubMed]
43. Fergusson DM, Lynskey MT, Horwood LJ. Childhood sexual abuse and psychiatric disorder in young adulthood: I. Prevalence of sexual abuse and factors associated with sexual abuse. J Am Acad Child Adolesc Psychiatry. 1996;35:1355–1364. [PubMed]
44. Minzenberg MJ, Poole JH, Vinogradov S. A neurocognitive model of borderline personality disorder: Effects of childhood sexual abuse and relationship to adult social attachment disturbance. Dev Psychopathol. 2008;20:341–368. [PubMed]
45. Molnar BE, Buka SL, Kessler RC. Child sexual abuse and subsequent psychopathology: Results from the National Comorbidity Survey. Am J Public Health. 2001;91:753–760. [PubMed]
46. Hendin H, Haas AP. Suicide and guilt as manifestations of PTSD in Vietnam combat veterans. Am J Psychiatry. 1991;148:586–591. [PubMed]
47. Makhija N, Sher L. Childhood abuse, adult alcohol use disorders and suicidal behaviour. QJM. 2007;100:305–309. [PubMed]
48. Krug EG, Dahlberg LL, Mercy JA, Zwi AB, Lozano R, editors. Geneva: World Health Organization; 2002. World Report on Violence and Health. [PubMed]

Articles from PLoS ONE are provided here courtesy of Public Library of Science