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[Cover image of issue]

Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): Assembly of hepatitis B virus capsids proceeds one dimer at a time; allostery of the dimeric capsid protein is hypothesized to play a regulatory role. The newly determined crystal structure of a free dimer (blue) shows conformational movements of up to 9 Å compared to a dimer from a capsid (yellow). Free dimer geometry is incompatible with capsid assembly, but an induced fit mechanism allows it to conform to the growing capsid. The partially complete T=4 capsid (PDB accession no. 2G33) is color-coded for quasiequivalence; any similarity to a fully functional death star is coincidental. This illustration was prepared using UCSF Chimera software. (See related article in February 2010, vol. 84, no. 3, p. 1607.)

J Virol. 2010 May; 84(10): Cover