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Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): The averaged structures of phosphorylated CRK and CRKL were obtained during the last 3 ns of molecular dynamics (MD), performed for a period of 10 ns, and used as template structures. To simulate interactions between the SH2 domain and each autophosphorylation site of fibroblast growth factor receptor 1 (FGFR1), the SH2 domain (red spacefill model) and the region around phosphotyrosine (pY) (cyan) corresponding to the pY peptide (green spacefill model) were extracted from the averaged structure. The amino acid residues in the pY peptide (green) were replaced with peptide residues from FGFR1 manually, and the structure of the pY peptide was energy minimized with atom position fixing of the SH2 domain. Shown is the CRK structure as an example. (See related article in June 2009, vol. 29, no. 11, p. 3076.)

Mol Cell Biol. 2010 May; 30(9): Cover