PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
Arch Dis Child. 1982 January; 57(1): 6–12.
PMCID: PMC2863282

Klinefelter's syndrome in adolescence.

Abstract

Twelve boys with Klinefelter's syndrome (47,XXY) identified by sex chromatin screening at birth were examined at between ages 16 and 18 years, together with 12 controls matched for social class and birth order from the same newborn population. Physical examination, psychometric assessment, personality, and degree of psychosexual development were assessed without knowledge of the karyotype. Anthropometry showed increased leg length and decreased head circumference in the XXY boys. Gynaecomastia was present in 4 boys, and testicular volume was reduced in the majority but one boy had normal sized testes. On the Wechsler intelligence scale there was a significant reduction in verbal score but not in either performance or full-scale score compared with the controls. Although appreciable differences were found in growth, personality, intelligence test scores, and psychosexual development, these were of small degree.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • MACLEAN N, HARNDEN DG, BROWN WM, BOND J, MANTLE DJ. SEX-CHROMOSOME ABNORMALITIES IN NEWBORN BABIES. Lancet. 1964 Feb 8;1(7328):286–290. [PubMed]
  • PASQUALINI RQ, VIDAL G, BUR GE. Psychopathology of Klinefelter's syndrome; review of thirty-one cases. Lancet. 1957 Jul 27;273(6987):164–167. [PubMed]
  • STEWART JS, MACK WS, GOVAN AD, FERGUSON-SMITH MA, LENNOX B. Klinefelter's syndrome: clinical and hormonal aspects. Q J Med. 1959 Oct;28:561–571. [PubMed]
  • Paulsen CA, Gordon DL, Carpenter RW, Gandy HM, Drucker WD. Klinefelter's syndrome and its variants: a hormonal and chromosomal study. Recent Prog Horm Res. 1968;24:321–363. [PubMed]
  • Becker KL. Clinical and therapeutic experiences with Klinefelter's syndrome. Fertil Steril. 1972 Aug;23(8):568–578. [PubMed]
  • Chandley AC, Edmond P, Christie S, Gowans L, Fletcher J, Frackiewicz A, Newton M. Cytogenetics and infertility in man. I. Karyotype and seminal analysis: results of a five-year survey of men attending a subfertility clinic. Ann Hum Genet. 1975 Oct;39(2):231–254. [PubMed]
  • Raboch J, Mellan J, Stárka L. Klinefelter's syndrome: sexual development and activity. Arch Sex Behav. 1979 Jul;8(4):333–339. [PubMed]
  • Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child. 1970 Feb;45(239):13–23. [PMC free article] [PubMed]
  • Prader A. Testicular size: assessment and clinical importance. Triangle. 1966;7(6):240–243. [PubMed]
  • Bem SL. The measurement of psychological androgyny. J Consult Clin Psychol. 1974 Apr;42(2):155–162. [PubMed]
  • Annell AL, Gustavson KH, Tenstam J. Symtomatology in schoolboys with positive sex chromatin (the klinefelter syndrome). Acta Psychiatr Scand. 1970;46(1):71–80. [PubMed]
  • Funderburk SJ, Ferjo N. Clinical observations in Klinefelter (47,XXY) syndrome. J Ment Defic Res. 1978 Sep;22(3):207–212. [PubMed]
  • Crandall BF, Carrel RE, Sparkes RS. Chromosome findings in 700 children referred to a psychiatric clinic. J Pediatr. 1972 Jan;80(1):62–68. [PubMed]
  • Nielsen J, Bjarnason S, Friedrich U, Froland A, Hansen VH, Sorensen A. Klinefelter's syndrome in children. J Child Psychol Psychiatry. 1970 Nov;11(2):109–119. [PubMed]
  • Caldwell PD, Smith DW. The XXY (Klinefelter's) syndrome in childhood: detection and treatment. J Pediatr. 1972 Feb;80(2):250–258. [PubMed]
  • Ratcliffe SG, Axworthy D, Ginsborg A. The Edinburgh study of growth and development in children with sex chromosome abnormalities. Birth Defects Orig Artic Ser. 1979;15(1):243–260. [PubMed]
  • Schibler D, Brook CG, Kind HP, Zachmann M, Prader A. Growth and body proportions in 54 boys and men with Klinefelter's syndrome. Helv Paediatr Acta. 1974 Oct;29(4):325–333. [PubMed]
  • Witkin HA, Mednick SA, Schulsinger F, Bakkestrom E, Christiansen KO, Goodenough DR, Hirschhorn K, Lundsteen C, Owen DR, Philip J, et al. Criminality in XYY and XXY men. Science. 1976 Aug 13;193(4253):547–555. [PubMed]
  • Schiavi RC, Owen D, Fogel M, White D, Szechter R. Pituitary-gonadal function in XYY and XXY men identified in a population survey. Clin Endocrinol (Oxf) 1978 Sep;9(3):233–239. [PubMed]
  • Stewart DA, Netley CT, Bailey JD, Haka-Ikse K, Platt J, Holland W, Cripps M. Growth and development of children with X and Y chromosome aneuploidy: a prospective study. Birth Defects Orig Artic Ser. 1979;15(1):75–114. [PubMed]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group