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Arch Dis Child. 1982 January; 57(1): 18–21.
PMCID: PMC2863277

Screening for cystic fibrosis by dried blood spot trypsin assay.


Immunoreactive trypsin was measured in dried blood specimens from 14,000 infants. A second test was performed in 0 . 2% of the population in whom blood trypsin levels were greater than 80 ng/ml. Five infants with cystic fibrosis were then detected, with only one case of persistent hypertrypsinaemia in whom this diagnosis could not be established. No false-negative test results have yet been identified. Seventeen infants with cystic fibrosis were tested inthe first 2 weeks of life, only one of whom had a blood trypsin concentration less than 80 ng/ml.

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Selected References

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  • King DN, Heeley AF, Walsh MP, Kuzemko JA. Sensitive trypsin assay for dried-blood specimens as a screening procedure for early detection of cystic fibrosis. Lancet. 1979 Dec 8;2(8154):1217–1219. [PubMed]
  • Crossley JR, Elliott RB, Smith PA. Dried-blood spot screening for cystic fibrosis in the newborn. Lancet. 1979 Mar 3;1(8114):472–474. [PubMed]
  • Applegarth DA, Davidson AG, Kirby LT, Bridges M, Sorensen P, Wong LT, Hardwick DF. Dried blood spot screening for cystic fibrosis. Lancet. 1979 Dec 8;2(8154):1236–1237. [PubMed]
  • Dandona P, Littlewood JM, Ramdial L, Evans R. Two tier screen for cystic fibrosis. Lancet. 1981 Feb 14;1(8216):380–380. [PubMed]
  • Forrest DC, Wilcken B, Turner G. Screening for cystic fibrosis by a stool trypsin method. Arch Dis Child. 1981 Feb;56(2):151–153. [PMC free article] [PubMed]

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