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Gastrointestinal symptoms in relation to the ingestion of proteins are common but only in the case of sensitisation to cows' milk protein, soy, or gluten have alterations in the function and structure of the small-intestine been reported. We describe 3 children with cows' milk protein intolerance and associated enteropathy related to fish, rice, and chicken, respectively. Repeated intestinal biopsies before and after an acute challenge with the specific food showed changes in the histological appearance of the intestinal mucosa identical with those observed after the acute administration of cows' milk. These findings support the conclusion that cows' milk-protein intolerance is not an isolated entity; it represents the first part of a broader intolerance of various dietary proteins.