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Indian J Occup Environ Med. 2009 December; 13(3): 155.
PMCID: PMC2862450

Rapid measurement of organophophorous level in serum

Dear Sir,

I have read the recent publication by Singh et al., with great interest.[1] The measurement of organophosphorous level is an important laboratory investigation in occupational medicine. Singh et al. reported the use of a chromatography-based technique for this purpose.[1] A good diagnostic property can be seen.[1] However, this is still a complicated technique. It needs a standard medical laboratory that poses the chromatography analyzer and requires an expert or medical technologist for performing the test. In addition, the cost of running the chromatographical analysis is high and the turnaround time starting from the specimen collection to the analysis in the laboratory with adequate facilities can be long. Rapid measurement for screening program should be less complex. Indeed, there are some alternative techniques that are more rapid for measurement. For example, Cho et al., reported an ELISA and ELISA dipstick technique.[2] In addition, No et al.,[3] also reported another new cholinesterase-based dipstick assay for the detection. These dipstick tests are more rapid that serve the analytical purpose.

REFERENCES

1. Singh B, Dogra TD. Rapid method for the determination of some organophosphorus insecticides in a small amount of serum in emergency and occupational toxicology cases. Indian J Occup Environ Med. 2009;13:84–7. [PMC free article] [PubMed]
2. Cho YA, Kim YJ, Hammock BD, Lee YT, Lee HS. Development of a microliter plate ELISA and a dipstick ELISA for the determination of the organo phosphorous insecticide fenthion. J Agric Food Chem. 2003;51:7854–60. [PubMed]
3. No HY, Kim YA, Lee YT, Lee HS. Cholinesterase-based dipstick assay for the detection of organophosphate and carbamate pesticides. Anal Chim Acta. 2007;594:37–43. [PubMed]

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