Genetic architecture of chemical resistance traits
Examples of genetically simple traits (A), examples of genetically complex traits (B), relationship between the number of expected and detected peaks (C), the number of loci detected per trait (D), and a map of compound-specific and pleiotropic loci across the genome (E). In (A) and (B), the −log10(p) values are shown for t-tests comparing selected samples to control samples. The sliding averages within 50 kilobase windows for these tests are plotted. In (C), the global relationship between expected and detected peaks is plotted as a black line and the trait-specific relationships are plotted as grey lines. The red line plots the relationship between expected and detected peaks at an FDR of 0.05. The expected counts were generated from permutations of the chemical resistance dataset. The histogram in (D) was made using loci significant at a global FDR of 0.05. In (E), detected loci were grouped within 20 kb windows across the genome.