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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Dev Biol. Author manuscript; available in PMC 2010 April 30.
Published in final edited form as:
Dev Biol. 2009 March 15; 327(2): 313–326.
Published online 2008 December 24. doi: 10.1016/j.ydbio.2008.12.010


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A model: unrestricted cross-midline divisions disrupt rhombomere boundaries in an EphA4; EfnB2a MO embryo.

In a WT hindbrain, daughter cells created by cross-midline divisions in r3, r4 and r5 are restricted by the presence of cell surface EphA4 and EfnB2a to intercalate well inside their respective rhombomeres of origin. Neuroepithelial cells in r3-5 in embryos lacking EphA4 and EfnB2a divide without such restrictions, leading to mis-sorting of daughters from r3 and r5 mothers into r4 and vice versa.

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