The large size of the population analyzed and the long time period (≈20 years) add strength to the study. Because one third of the study population were considered illegal aliens and lacked health insurance, our analysis was able to provide valuable information about infections affecting a group that is frequently not adequately represented in published studies because of the usual restrictions on access to health services. Nonetheless, this study is subject to several limitations.
In Spain, most immigrants come from a European Union member state (Romania, 14% of all immigrants in Spain), followed by northern Africa (Morocco, 12%) and Latin America (Ecuador, 8%) (2
). Extrapolation of the results of this study to the global immigrant population may therefore be limited. However, these mobile groups are important because of the spectrum of imported diseases represented. This applies both to tropical diseases and transmissible infections (5
Comparison based on geographic distribution may exclude other important aspects involved in the development of certain infectious diseases: socioeconomic status of the country, public health infrastructure, rural or urban origin, or reason for migration. However, characteristics of most immigrants seen at TMU were similar: most came from tropical, underdeveloped areas of Latin America and sub-Saharan Africa, and most migrated for economic reasons.
During the 20 years of data collection, diagnostic methods and screening procedures changed, thus influencing results over time. Depending on how the patients were referred to our clinic the frequency of the various diseases reported cannot be interpreted as prevalence rates in the 2 migrant populations considered. Because most individuals were referred for investigation of symptoms or diseases, the frequency observed can be expected to be higher than in the overall migrant population.
Demographic variables of age and sex are in accordance with national data on immigrant populations (2
) and are similar to other series (6
), except for the larger proportion of males in the Latin American group. The significant difference in the preconsultation periods of the 2 groups might be explained by the larger proportion of Latin Americans who held health cards and thus were seen initially by general practitioners. Because most sub-Saharan African immigrants were undocumented and referred from NGOs, TMU was their first contact with the public health system. Nevertheless, the proportion of Latin Americans seen at TMU as a result of active health promotion campaigns and screening for Chagas disease increased.
Consistent with other series (8
), the most frequent reasons for seeking medical assistance at TMU were hematologic–eosinophilia, dermatologic syndrome, and fever. All syndromes occurred significantly more often in sub-Saharan Africans, except for respiratory and neurologic. Geographic variation in disease distribution would explain certain differences. The increased frequency of dermatologic syndrome and eosinophilia in Africans could be due to the greater incidence of filariasis; anemia could result from nutritional deficiencies and hemoglobinopathies; and fever could be due to malaria. For Latin Americans, increased prevalence of neurocysticercosis and TB might explain the increased frequency of neurologic and respiratory syndromes.
The most common tropical disease was filariasis, with onchocerciasis the most frequent filarial infection, affecting sub-Saharans significantly more often than Latin Americans. More than 99% of symptomatic onchocerciasis occurs in western sub-Saharan Africa, where most of the patients in the study originated. The number of cases diagnosed at TMU, however, has progressively decreased since 2000. Screening for filariasis by microfilaremia detection and skin snips should probably be considered in patients presenting pruritus or eosinophilia (9
In Europe, as in Spain, immigrants account for approximately 50% of malaria cases (10
). In our series, as in other national (11
) and international (12
) studies, most malaria patients were from sub-Saharan Africa, and the most commonly isolated species was P. falciparum
. However, P. vivax
was the principal species diagnosed in Latin Americans. A considerable number of patients were asymptomatic at diagnosis, probably because of partial immunity developed during residence in areas to which malaria is endemic (13
) and the implementation of PCR for Plasmodium
spp. as a screening test in sub-Saharan Africans, which enables detection of very low parasitemia. Malaria screening should be considered in newly arrived immigrants from areas to which it is endemic, regardless of clinical presentation (14
); in specialized referral centers, such as TMU, PCR with its higher sensitivity and specificity should be available.
Migration is changing the geographic distribution of Chagas disease, which until recently has been limited to Latin America. During the 1970s, the United States was the leading recipient of Latin American migrants but Europe (especially Spain) is now a main recipient (16
). A recent study in Spain estimated the number of immigrants potentially infected with Trypanosoma cruzi
could range from 37,000 to 122,000 (17
). Alternate, nonvectorial, routes of transmission (vertical or through blood transfusion or organ transplantation) and reactivation episodes in inmunosuppressed persons make Chagas disease an emerging and potentially transmissible disease in the autochthonous population, and thus an important public health concern (18
). Furthermore, severe cardiac disease could develop in infected persons; a broader knowledge of this aspect of the disease by clinicians is necessary. In our series, prevalence reached nearly 16% among Latin Americans. Bolivian patients accounted for 95% of cases, reflecting its high endemicity (19
). Electrocardiographic and echocardiographic disorders were found in 15.9% and 7.3% of patients, respectively. These results suggest that all immigrants from areas to which it is endemic should be screened.
In the literature, the prevalence of intestinal parasites in immigrants ranges from 11% to 67%, depending on the origin and type of immigrant, with higher frequencies in recently arrived refugees and sub-Saharan Africans (7
). However, we found a low prevalence (11%). The impact of intestinal parasitism is low because a considerable proportion of affected persons are asymptomatic, and illness is generally low, with certain parasites (e.g., Strongyloides stercoralis
). In our study, 11.5% of patients had no symptoms. These findings question the usefulness of screening the migrant population from areas to which it is endemic for intestinal parasitism. Some authors propose empiric treatment with albendazole (23
), effective against S. stercoralis
and G. intestinalis
), as the most cost-effective measure. Others argue against this measure for reasons such as potential side effects, possible incorrect treatment of certain pathogens (e.g., Entamoeba histolytica
), and the inherent risks of treating a patient with neurocysticercosis. Although further studies are necessary to assess advantages and risks of empiric treatment over screening (15
) as a public health measure, an alternative approach could be selective screening of high-risk groups, such as pregnant women, children, and inmunosuppressed patients.
TB is an example of an infectious disease that has emerged with the increase in mobile populations (25
). Prevalence of active TB among immigrants is higher than in the host population. We found active TB more often in Latin Americans than in sub-Saharan Africans, similar to other national studies (26
). That TB prevalence rates/100,000 population are as high as 195 and 266 in Ecuador and Bolivia, respectively (World Health Organization data, 2006, http://apps.who.int/globalatlas/dataQuery/default.asp
), the most common countries of origin of our Latin American group, might explain this result. Median interval from arrival in Spain to presentation with TB was 2 years, which is consistent with previous studies showing a higher risk for TB during the first 2–5 years of residence in the host country and where activation of latent TB infection seems to be a common cause of TB among immigrants (27
). The rate of latent TB (32.6%) in our study was consistent with other series (7
). Latent TB occurred more often in sub-Saharan Africans than in Latin Americans.
Public heath interventions for control of TB in the immigrant population are intensely debated. Many authors consider that interrupting the ongoing community TB transmission through detection and treatment of active TB and contact investigation is the best cost-effective strategy (28
). However, current guidelines in certain countries recommend screening for latent TB in immigrants, especially those who entered the host country within the previous 5 years (29
). Screening policies for latent TB face several difficulties, and no consensus has been reached, the best screening method is under discussion (chest radiographs, intradermal tuberculin test [IDT]), IDT interpretation is ambiguous (3 cutoff points may be considered), the false-positive rate is high because of BCG (Mycobacterium bovis BCG) vaccination, and ensuring high rates of treatment completion for latent TB in the migrant population has proven difficult (31
). Nevertheless, with the implementation of new screening techniques (interferon gamma release assay) that are less affected by BCG vaccination (32
) and use of culturally adapted programs to improve adherence to treatment, screening for latent TB followed by appropriate treatment could be a successful strategy for global TB control in Western countries. Some studies support a better, cost-effective approach to TB using screening (33
Chronic HBV infection is a major health problem in sub-Saharan Africa and Asia, where prevalence is >8% (34
). The mortality rate from chronic infection is ≈25% because of complications (liver cirrhosis and hepatocellular carcinoma). The 9.8% prevalence in our study was similar to others (7
). In developing countries, many infections are acquired during the perinatal period, and patients develop long-term complications in early adulthood, whereas in developed countries, infection and complications occur later in life. Screening for HBV in sub-Sahara African immigrants would help detect chronic infections in young adults, allowing early treatment and monitoring for complications. This could also prompt contact screening, vaccination, and education as preventive measures (15
). Finally, when an isolated core antibody pattern is detected, a relatively common serologic result in the sub-Saharan African population, PCR assessment for occult chronic infection for HBV DNA may be required, especially in HIV-positive patients (35
STIs other than HIV and viral hepatitis were diagnosed in 4.8% of the total population studied. Most STIs were due to latent syphilis (60%), particularly in the Africans. This trend toward more bacterial STIs in certain groups, such as immigrants, is consistent with observations throughout Spain and Europe (36
). Most STIs, particularly syphilis, can be easily misdiagnosed because they can run a mild or asymptomatic course, but complications and sequelae can be severe. Moreover, syphilis can be easily transmitted from mother to child. Intervention programs for immigrants, particularly sub-Saharan Africans, with active screening and treatment for syphilis could reduce the prevalence and transmission of this infection in the community.
In December 2007, the Joint United Nations Programme on HIV/AIDS (37
) stated an estimated 33.2 million persons were living with HIV infection worldwide, with most (22.5 million) living in sub-Saharan Africa. In our series, HIV infection also occurred significantly more often among sub-Saharan Africans than among Latin Americans. Throughout western Europe, HIV infection increasingly, and disproportionately, affects immigrants from countries in which the prevalence of HIV/AIDS is high and, in most countries, accounts for the majority of heterosexually acquired HIV infections diagnosed in recent years (38
). In some series, HIV is diagnosed in immigrants and refugees at a later stage of infection, with lower CD4 cell counts, a larger proportion of females, and with different HIV subtypes (39
). This highlights the need for screening immigrants, particularly sub-Saharans, for HIV to enable early diagnosis and treatment as well as prevention and education. A larger social and cultural program support is necessary to ensure adequate treatment as well as access to the health care system.
Increased population mobility has led to the disappearance of existing barriers for the spread of certain diseases. Characteristics of mobile populations are becoming increasingly heterogeneous (4
). Epidemiologic studies in mobile groups help determine factors possibly associated with greater risk for certain pathologies and identify which of the latter may influence health to a greater extent. Our study may improve knowledge about pathology in 2 important mobile populations in Spain, enabling early diagnosis and treatment of potentially transmissible infections (TB), education and prevention programs (STIs, HIV) and catching up on vaccination (40
), with ensuing positive public health repercussions. Future research may focus on development of diagnostic protocols for imported diseases on the basis of epidemiologic findings.