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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
Am J Hosp Palliat Care. Author manuscript; available in PMC 2010 August 1.
Published in final edited form as:
PMCID: PMC2855225
NIHMSID: NIHMS188316

Three Lessons from a Randomized Trial of Massage and Meditation at End of Life: Patient Benefit, Outcome Measure Selection, and Design of Trials with Terminally Ill Patients

Abstract

Improving end-of-life care is a priority in the United States, but assigning priorities for standard care services requires evaluations using appropriate study design and appropriate outcome indicators. A recent randomized controlled trial with terminally ill patients produced no evidence of benefit from massage or guided meditation, when evaluated with measures of global quality of life or pain distress over the course of patient participation. However, reanalysis using a more targeted outcome, surrogates’ assessment of patients’ benefit from the study intervention, suggested significant gains from massage – the treatment patients gave their highest pre-assignment preference ratings. The authors conclude that adding a menu of complementary therapies as part of standard end-of-life care may yield significant benefit, that patient preference is an important predictor of outcome, and that modifications in trial design may be appropriate for end-of-life studies.

Keywords: complementary and alternative medicine, end of life, hospice care, palliative care, patient benefit, patient preference, clinical trial design, outcome measure selection

Introduction

“You never ask how important it is to me to receive this service … I so much look forward to it … I’m amazed you don’t ask me this question. It should be the featured question.”

(Unsolicited comment from a patient in the study)

During the past two decades, improving the quality of end-of-life care has become a priority in the United States. Management or elimination of previously fatal acute diseases that brought death to the young, an aging population whose protracted end-of-life period is complicated by comorbidities, and the imminent arrival at old age by the politically powerful “baby boom” generation have brought new urgency to the consideration of palliative care. As in other healthcare areas, the movement toward evidence-based medicine requires scientific justification for establishing treatment guidelines for care at end of life. In a 1997 report,1 the Institute of Medicine’s Committee on Care at the End of Life called for research to identify methods for improving care of persons approaching death, thus underscoring the importance of evaluating services that might benefit terminally ill patients if added to standard end-of-life care.

Among the difficulties encountered in evaluating interventions for improved care, however, is the choice of appropriate outcome indicators. Although this difficulty is not unique to end-of-life trials, measurement is particularly problematic in the study of dying and death, where best measurement practice supports use of patient and family reports of experience, in addition to more objective measures.2 Researchers have noted the insensitivity of some established measures of this type to interventions of interest,24 calling attention to their failure to permit detection of benefit implied by other outcomes – notably patients’ seeking of additional treatment sessions during clinical trials or continuation of treatment after trial conclusion.3,4

Following a recent randomized clinical trial with terminally ill patients, we evaluated the impact of two complementary and alternative medicine (CAM) therapies (massage and guided meditation/visualization) on patients’ end-of-life experience. In analyses using three outcome indicators (patients’ global quality of life and pain distress ratings collected throughout the service delivery period, and surrogates’ ratings of patients’ quality of life during the final week before death), we found no significant effects of either CAM treatment, when compared to an attention control condition (friendly visits).5 However, during surrogate interviews after patients’ deaths, we collected information on two additional outcomes: the surrogate’s assessment of the specific impact of the study treatment on the patient’s and their own quality of life. In this article we report findings related to these additional outcomes and discuss the potential implications for selecting outcome measures and designing trials for future end-of-life research.

Methods

Study Sample

Outcome data came from 108 “study partners” of terminally ill patients, collected during interviews subsequent to patients’ deaths. The patients had participated in a randomized clinical trial testing the efficacy of two CAM therapies: massage and guided meditation/visualization.

A detailed description of the larger clinical trial appears elsewhere.5 However, in brief, patients living in the Seattle, Washington, metropolitan area were eligible for participation if they had been diagnosed with AIDS or stage IV cancer or were enrolled in a hospice or palliative care program, and if their survival prognosis was between 3 weeks and 6 months. The study protocol excluded patients who were under 18 years of age, did not speak English, would not accept random assignment, or were not capable of providing reliable responses to a 60–90 minute baseline interview. Interviews could be continued over a series of shorter sessions if patients’ endurance was limited. After the baseline interview enrollees were randomized to one of three treatment conditions – massage, guided meditation/visualization, or friendly visits provided by, respectively, licensed massage therapists, licensed naturopathic physicians, or certified hospice volunteers. The assigned practitioner then provided up to two treatment visits per week. After every two treatment visits, participating patients completed a short follow-up interview, either by telephone or in person, depending upon their preference. Receipt of additional treatment was contingent upon completion of the follow-up interview until the research staff deemed the patient no longer capable of interview. Treatment continued until the patient’s death or voluntary withdrawal from the study. All treatment and data-gathering sessions occurred on a schedule of the patient’s choice, and both treatment visits and in-person interviews were at locations of the patient’s choice – typically at home, but occasionally in hospitals or clinics.

At the time of study enrollment, each patient nominated a study partner who could provide collateral information at baseline and follow-up information after the patient’s death. Most study partners were family members or close friends of patients; a few were professional healthcare providers of socially isolated patients. Many were the patient’s primary caregiver.

Measures

Our primary outcome of interest was the perceived effect of the study treatment on the patient’s quality of life during study participation. A secondary outcome of interest was the effect of the patient’s study-delivered treatment on the responding study partner’s quality of life. For both outcomes the response options ranged from 0 (the very worst effect I can imagine) to 10 (the very best effect I can imagine).

We considered two primary predictors: the patient’s randomization group (massage, guided meditation, or friendly visits), and a dichotomous variable indicating whether the patient was randomized to her/his preferred treatment group. We based the latter variable on ratings patients assigned to the three treatment groups prior to randomization. Using a rating scale ranging from 0 (really disappointed) to 10 (really happy), they indicated their anticipated response in the event that they were assigned to each of the three treatment groups. If they were ultimately randomized to the group that received (or tied for) their top rating, we considered them assigned to their preferred treatment; if they gave a higher rating to a treatment other than their randomization group, we considered them assigned to a non-preferred treatment.

We investigated several additional variables, both as secondary predictors of interest and as potential confounders of associations between the primary predictors and outcomes: from the baseline interviews, the gender, racial-ethnic minority status, age, and educational level of patient and study partner; the relationship between patient and study partner, their length of association, and whether they lived together at the time of the patient’s enrollment in the study; the patient’s primary life-limiting diagnosis, use of CAM before study enrollment, and enrollment in hospice during the end-of-life period. In addition, we measured the patient’s baseline single-item rating of global quality of life (0 = no quality of life to 10 = perfect quality of life) and the patient’s baseline symptom distress score (a composite measure based on the Memorial Symptom Assessment Scale; 0 = no symptoms to 4 = high symptom distress),6 as well as the number of days the patient participated in the study between enrollment and death.

Analysis Methods

The distributions of both outcomes showed significant departure from the normal distribution (p-values for both the Kolmogorov-Smirnov and Shapiro-Wilk tests = 0.000). Therefore, we based findings on ordinal logistic regression models. We considered any variable that altered the odds ratio (OR) for the primary predictor by 15% or more in either direction, when added to the bivariate model, to be a confounder, and reevaluated the association between the primary predictor and outcome after adjustment for confounders. We used Microsoft Access 2002 for data management, SPSS 14.0.07 for descriptive and simple nonparametric statistics (Pearson’s χ2, Fisher’s Exact, Mann-Whitney, Kruskal Wallis, and Friedman tests), and Mplus 5.18 for regression modeling.

Results

Completion Rates

We randomized 167 patients to the three treatment groups: 56 (33.5%) to massage, 56 (33.5%) to meditation, and 55 (32.9%) to friendly visits. Of these, 28 patients (16.8%) withdrew from the study before death, with the remaining 139 completing the study. Although patient withdrawal was considerably higher from the meditation and friendly visit groups than from the massage group, attrition rates between groups did not differ significantly: 6 (10.7%) from the massage group, 12 (21.4%) from the meditation group, and 10 (18.2%) from the friendly visit group (χ2 = 2.421, df = 2, p = 0.298). Withdrawal was significantly higher among patients assigned to a non-preferred treatment than among those assigned to a preferred treatment (22.2% vs. 9.6%, Fisher’s Exact Test = 0.035).

Of the 139 patients who completed the study, 117 died during study participation, with the remaining 22 surviving to the end of the study. The decedents included 40 patients assigned to massage, 38 to meditation, and 39 to friendly visits. Study partners of 108 (92.3%) of the 117 decedents completed follow-up interviews: 37 (92.5%) from the massage group; 34 (89.5%) from meditation; and 37 (94.9%) from friendly visits. Follow-up rates for study partners did not differ significantly between treatment groups (χ2 = 0.793, df = 2, p = 0.673), but were higher for non-preferred than for preferred treatments: (98.3% vs. 87.0%; Fisher’s Exact Test = 0.026).

Characteristics of the Responding Study Partners and the Decedents They Represented

Study partners and decedents were predominantly white non-Hispanic women, study partners averaging about 54 years of age and decedents about 20 years older. The median length of association between study partners and decedents was 41 years. More than half of the study partners and over 40% of the decedents had college or advanced degrees. Most study partners were either spouses or children of decedents, and almost half lived with the decedent at the time of enrollment in the study. Almost one-third of the patients had used some form of CAM (broadly defined) during the year before study enrollment, over 90% were enrolled in hospice at the time of death, and over 70% died with cancer. At the time of study enrollment most patients rated their quality of life as reasonably high (median = 7 on a 0–10 scale) and their symptom distress relatively low (1 on a 0–4 scale). Overall, patients gave high pre-assignment ratings to the treatment to which they were ultimately assigned (median = 8 on a 0–10 scale), and over 44% were assigned to a preferred treatment. (Table 1)

Table 1
Characteristics of Study Partners and Deceased Patients

Patients’ pre-assignment ratings differed significantly for the three potential treatment assignments, with median ratings for massage highest (8), followed in order by friendly visits (7) and meditation (6). Pre-assignment ratings of the treatment actually assigned were, similarly, significantly different by treatment group (with median ratings of 10, 8, and 6, respectively, for massage, friendly visits, and meditation) and by whether the patient was assigned to a preferred or non-preferred treatment (median ratings of 10 and 5, respectively). (Table 2)

Table 2
Patients’ Pre-Assignment Ratings of the Study Treatments

Association of Predictors of Interest with Benefit from Study Treatment Sessions

Study partners’ ratings of the impact of the study treatment sessions on patients’ quality of life showed considerable variability, and – before adjustment for confounders – were significantly associated with patients’ baseline quality of life, length of time in the study, assignment to the massage group, and assignment to a preferred treatment (Table 3).

Table 3
Unadjusted Associations between Predictors/Covariates and Patient Benefit from Study Treatmenta

However, several variables acted as confounders. First, patients who were assigned to their preferred treatment reported slightly higher symptom distress at baseline than did their counterparts. Adjustment for this confounder increased the odds ratio (OR) for assignment to preferred treatment, revealing an even stronger benefit for treatment matching.

Three variables (baseline quality of life, prior use of CAM, and assignment to preferred treatment) confounded the association between massage and treatment benefit. The strongest of these was assignment to preferred treatment. Patients assigned to the massage group were significantly more likely than their counterparts to have been assigned to their preferred treatment (68.6% of the massage group, 29.4% of the meditation group, and 35.1% of the friendly visit group having given their top rating to the assigned group; χ2 = 12.667, df = 2, p = 0.002). Addition of the preferred treatment predictor to the regression model reduced the OR for massage to 2.037 and rendered it statistically nonsignificant (p = 0.108). Although massage offered some benefit to patients in this sample, over and above benefit derived from being assigned to their treatment of choice, the effect was not strong enough to be generalizable beyond the sample.

A multivariate model of patients’ benefit from study treatment sessions retained three significant predictors of benefit from treatment (Table 4). Based on study partners’ ratings, patients received significantly greater benefit if they were assigned to their preferred treatment, reported higher quality of life at the time of study enrollment, and participated longer in the study.

Table 4
Multivariate Model: Patient Benefit from Study Treatmenta

In addition to benefit gained by patients, study partners indicated that they, themselves, benefited more when their patient was assigned to their preferred treatment. The median ratings of treatment benefit to study partners of patients assigned to preferred versus non-preferred treatments were 6 and 5, respectively (Mann-Whitney Z-approximation = −2.277, p = 0.023).

Discussion

Our analysis of study partners’ perceptions of patient benefit from three treatments offered in a clinical trial suggests that therapeutic massage over an extended end-of-life period may offer enhanced benefit to terminally ill patients, when compared with either guided meditation/visualization or friendly visits. Of even greater potential benefit, however, is the matching of available treatments to those actively preferred and requested by patients. In fact, much of the apparent benefit of massage over the other two therapies resulted from patients’ prior preference for massage. These findings were counter to results obtained in earlier analyses of patients’ global quality-of-life and pain distress, rated by both patients and their study partners, which did not vary significantly by treatment assignment or treatment matching.5 Our current analyses also showed evidence of benefit to patients’ significant others when patients received their preferred treatment.

Other researchers studying palliative care have noted problems related to selection of outcome measures and have suggested the importance of developing and testing measures optimal for the specific research context, rather than relying exclusively on already existing standard measures.9 The outcomes selected must be sensitive to potential effects of the intervention,10,11 and measures of global quality of life and pain distress may be too broad to allow detection of effects by interventions of the type we studied. Moreover, such outcomes may be affected by disease-related factors and personal circumstances, in addition to factors related to care.12 Our patients evaluated global quality of life and pain distress at follow-up interviews, occurring at least one calendar day following treatment, with over 28% of the interviews occurring 3 or more days after treatment. Similarly, surrogate respondents rated the quality of patients’ last week of life, a period that was sometimes substantially removed from their final treatment visit. (About 15% of patients had their final treatment 3 weeks or more before death.) These patient and study partner ratings were potentially influenced by numerous factors subsequent to intervention delivery.

The outcome we used for the current article – surrogate respondents’ perceptions of the specific effects of the study treatment on quality of life – was a late addition to the study partner follow-up interview, and we failed to add a comparable question to interviews with patients during their study participation. The unsolicited comment from one of our clinical trial participants, presented as an epigraph to this article, suggests that patients might have welcomed such an addition. Although the growing emphasis on family-centered care underscores the importance of soliciting evaluations from patients’ intimate associates, collecting this information directly from patients, as well, would have strengthened our investigation. Researchers considering clinical trial outcome measures have noted not only that omission of important outcomes may waste resources and produce misleading results that miss potential benefits of an intervention, but that investigators would do well to involve consumers (i.e., the affected populations) in both clinical trial design and the selection of measures.13 In the words of one healthcare researcher, “Clinical trials are only as credible as their endpoints.”14 Selection of credible endpoints remains a worthy goal for investigators.

Additionally, our finding that study partners’ assessments of study benefit were significantly associated with patients’ assignment to a preferred treatment has implications for design of intervention studies at end of life. Randomization of terminally ill patients to non-preferred treatments, particularly if there is no opportunity for later receipt of a preferred treatment, presents an ethically questionable use of patients’ limited time and energy. Almost 20 years ago two British researchers recommended that studies randomize only those patients who have no treatment preference and assign all other participants to their treatment of choice – allowing tests of both treatment efficacy and participant motivation.15 This recommendation has received little notice to date in the design of intervention evaluations and is nowhere more relevant than in end-of-life studies.

Limitations

Our study is based on a small number of participants from a single geographic area and may not reflect patterns that exist in more inclusive samples. Moreover, because the outcomes we investigated were perceptions of decedents’ surrogates, rather than those of the patients who actually received the study treatments, findings may not match those that would have obtained had we questioned patients directly.

Conclusions

The explicit purpose of our clinical trial was to test whether either of two nontraditional therapies – massage or guided meditation –might provide quality-of-life improvements sufficient to warrant their integration into standard end-of-life care. The outcomes on which we based our primary analysis – traditional measures of global quality of life and pain distress – clearly provided important information in the evaluation of treatment efficacy. However, more tightly focused questions regarding surrogates’ perceptions of benefit from the interventions led to different conclusions, and these findings also merit consideration. Results of the present analyses suggest three lessons. First, targeted questions about treatment benefit are worth including in patient assessment batteries used in future trials. Our failure to elicit this information directly from patients required that we infer benefit from one step removed. Inasmuch as patients’ perceptions are the most germane to assessment of benefit, they will be essential for making informed decisions regarding potential changes in standard care protocols. Second, the strong and significant association between perceived benefit and patients’ assignment to a preferred treatment underscores the importance of reevaluating the appropriateness of randomized controlled trials for end-of-life research. Finally, making massage, as well as other coveted CAM therapies, available as regularly offered options to enrollees in hospice and palliative care programs may offer significant benefit, particularly if provided over an extended period. Determining the appropriate payment mechanisms for such services will require further research.

Acknowledgments

The National Institutes of Health / National Cancer Institute (grant #5R01-CA106204) and the Lotte & John Hecht Memorial Foundation provided funding for this study.

The authors are grateful for the time, energy, and good will provided by the participating patients, their family and friends, and their hospice and palliative care providers.

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