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Indian J Ophthalmol. 2010 Mar-Apr; 58(2): 176.
PMCID: PMC2854468

Fibrin glue in ophthalmology

Dear Editor,

We read with interest the article by Panda et al.,[1] wherein the authors have presented the uses of fibrin glue in ophthalmology in detail. They have mainly discussed its use on the ocular surface as a replacement of sutures.

Fibrin glue has exciting intraoperative applications during vitreoretinal surgeries as well. It has been found to not have any toxic effects on retinal function or structure in a rabbit model.[2] The intraoperative use of Tisseel VH fibrin sealant (Baxter Healthcare Corporation, Westlake Village, CA, USA) has been described recently in the management of optic disc pit-associated macular detachments.[3,4] The technique involves pars plana vitrectomy, removal of posterior hyaloid, fluid-air exchange, drainage of subretinal fluid through optic disc pit, application of the fibrin sealant to the pit and air–C3F8 gas exchange and postoperative prone positioning. This prevents recurrent macular detachment, which is common in this condition.

Fibrin glue has also been used to stabilize keratoprosthetic devices during vitreoretinal surgeries.[5]


1. Panda A, Kumar S, Kumar A, Bansal R, Bhartiya S. Fibrin glue in ophthalmology. Indian J Ophthalmol. 2009;57:371–9. [PMC free article] [PubMed]
2. Pardue MT, Hejny C, Gilbert JA, Phillips MJ, Geroski DH, Edelhauser HF. Retinal function after subconjunctival injection of carboplatin in fibrin sealant. Retina. 2004;24:776–82. [PubMed]
3. Al Sabti K, Kumar N, Chow DR, Kapusta MA. Management of optic disc pit associated macular detachment with Tisseel® fibrin sealant. Retinal Cases and Brief reports. 2008;2:274–7. [PubMed]
4. Kumar N, Al Sabti K. Optic disc pit maculopathy treated with vitrectomy, internal limiting membrane peeling, and gas tamponade: A report of two cases. Eur J Ophthalmol. 2009;19:897–7. [PubMed]
5. Uhlig CE, Gerding H. Fibrin sealing improves stability of corneal prostheses during vitreoretinal procedures. Retina. 2003;23:209–14. [PubMed]

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