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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Dev Neurobiol. Author manuscript; available in PMC 2010 November 1.
Published in final edited form as:
Dev Neurobiol. 2009 November; 69(13): 871–884.
doi: 10.1002/dneu.20747

Figure 7

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Model of G93A-SOD1 and VEGF effects on MNs

Expression of G93A-SOD1 in MNs results in decreased endogenous production of VEGF and the activation of caspase-3 ultimately resulting in cell death. Addition of exogenous VEGF activates VEGFR2 and subsequent PI3K/Akt and p44/42 MAPK signaling. Activation of PI3K/Akt signaling prevents G93A-SOD1-induced caspase-3 activation and cell death.

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