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Logo of bmcmdBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Medical Genetics
 
From:
Published online 2010 March 24. doi: 10.1186/1471-2350-11-46

Table 1

Adjusted odds ratio (AOR) and 95% confidence intervals (CIs) of hepatocellular carcinoma associated with genotypic frequencies and demographic characteristics distributions.

VariableControls (n = 386) (%)Patients (n = 177) (%)OR (95% CI) p valueAOR (95% CI) p value
GSTP1

II272 (70.5%)112 (63.3%)1.001.00

IV107 (27.7%)58 (32.7%)1.31 (0.8-1.9) p = 0.161.16 (0.7-1.7) p = 0.46

VV7 (1.8%)7 (4.0%)2.42 (0.8-7.0) p = 0.102.26 (0.7-7.1) p = 0.16


II272 (70.5%)112 (63.3%)1.001.00

IV or VV114 (29.5%)65 (36.7%)1.38 (0.9-2.0) p = 0.091.24 (0.8-1.8) p = 0.28


GSTA1

AA304 (78.8%)146 (82.5%)1.001.00

AB78 (20.2%)30 (16.9%)0.80 (0.5-1.2) p = 0.340.89 (0.5-1.4) p = 0.66

BB4 (1.0%)1 (0.6%)0.52 (0.05-4.7) p = 0.560.34 (0.04-3.5) p = 0.38


AA304 (78.8%)146 (82.5%)1.001.00

AB or BB82 (21.2%)31 (17.5%)0.78 (0.4-1.2) p = 0.360.85 (0.5-1.3) p = 0.52


GST genes

Combination 1212 (54.9%)92 (52.0%)1.001.00

Combination 2152 (39.4%)75 (42.3%)1.13 (0.7-1.6) p = 0.511.05 (0.7-1.5) p = 0.77

Combination 322 (5.7%)10 (5.7%)1.04 (0.4-2.4) p = 0.811.08 (0.4-2.5) p = 0.84


Age (yrs)

54.37 ± 0.7763.88 ± 0.81p < 0.0001


Gender

Male257 (66.6%)128 (72.3%)1.001.00

Female129 (33.4%)49 (27.7%)0.76 (0.5-1.1) p = 0.171.08 (0.7-1.6) p = 0.72


Residential areaMid-TaiwanMid-Taiwan

RaceAsianAsian

EthnicityTaiwaneseTaiwanese

The odds ratios (ORs) with their 95% CIs were estimated by logistic regression models.

The adjusted odds ratios (AORs) with their 95% CIs were estimated by multiple logistic regression models, after controlling for age, gender and genotypes for each estimated variable.

Mann-Whitney U test or Fisher's exact test was used between healthy controls and HCC patients.

Combination 1: Individuals with Ile/Ile of GSTP1 and *A/*A of GSTA.

Combination 2: Individuals with either genotype Ile/Val or Val/Val of GSTP1 or genotype *A/*B or *B/*B of GSTA1.

Combination 3: Individuals with genotype Ile/Val or Val/Val of GSTP1 and genotype *A/*B or *B/*B of GSTA1.