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Published online 2010 April 8. doi: 10.1371/journal.pgen.1000902

Table 1

Yeast deletion strains synthetically sick with truncated LRRK2 or suppressors of the toxicity induced by truncated LRRK2.
StrainHomologSynthetically sick or suppressorFunction
ahc2Δ NoSynthetically sickPutative transcriptional regulator; proposed to be an Ada Histone acetyltransferase complex component
rmd8Δ NoSynthetically sickCytosolic protein required for sporulation; Required for Meiotic nuclear Division
gcn4Δ NoSuppressorBasic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation
ade16ΔNoSuppressorEnzyme of ‘de novo’ purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities
yhl005cΔNoSuppressorUnknown ORF, Dubious ORF
slt2ΔYesSuppressorSerine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
gfd2Δ NoSuppressorIdentified as a high-copy suppressor of a dbp5 (Dead Box protein) mutation
cce1Δ NoSuppressorMitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA
gcs1Δ YesSuppressorADP-ribosylation factor GTPase activating protein 1 (ARFGAP1), involved in ER-Golgi transport; shares functional similarity with Glo3p
The homolog category indicates yeast genes with clear human homologs.