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Paediatr Child Health. 1998 Jul-Aug; 3(4): 251.
PMCID: PMC2851345

Acetaminophen and ibuprofen

Answer the following questions by circling the letter of the correct answer. Answers can be found on the inside back cover

  1. Which of the following statements about fever are true:
    1. if uncomplicated, fever is relatively harmless and is an important immunological defence mechanism
    2. severity and/or pattern does not correlate with etiology
    3. treatment with antipyretics does not prolong illness or adversely affect outcome
    4. response to antipyretics does not distinguish between serious and uncomplicated disease
    5. prophylaxis with acetaminophen 15 mg/kg may be of benefit in children with a family history of convulsive disorder at the time of diphtheria, polio and tetanus vaccination every 4 h for three doses
  2. Significant antipyresis can be achieved with single doses of
    1. acetaminophen 10 to 15 mg/kg
    2. acetaminophen 5 to 8 mg/kg
    3. ibuprofen 5 to 10 mg/kg
    4. ibuprofen 12 to 15 mg/kg
  3. Appropriate dosing intervals are
    1. alternate every 2 h acetaminophen and ibuprofen
    2. acetaminophen 4 to 6 h
    3. alternate every 4 h acetaminophen and ibuprofen
    4. ibuprofen 6 to 8 h
  4. Which of the following statements about the use of acetaminophen and ibuprofen in pain relief are true?
    1. acetaminophen may provide relief of mild to moderate pain
    2. ibuprofen may provide relief of mild to moderate pain
    3. acetaminophen and ibuprofen are more effective than placebo in about half of the children tested
    4. acetaminophen and ibuprofen should be considered before more potent agents
    5. some studies have been hampered by the lack of placebo controls
  5. Acetaminophen must be recommended over ibuprofen because of the following safety issues.
    1. vastly greater experience with acetaminophen
    2. good controlled studies comparing the safety of the two drugs
    3. insufficient use of ibuprofen to rule out rare serious events
    4. association of ibuprofen with Reye’s syndrome
    5. none of the above; there is no preference of acetaminophen over ibuprofen

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