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J Bacteriol. 1971 May; 106(2): 519–522.
PMCID: PMC285125

Non-Mendelian Mutation Allowing Ureidosuccinic Acid Uptake in Yeast


Mutants of Saccharomyces cerevisiae capable of growth on a minimal medium supplemented with ureidosuccinic and glutamic acids have been isolated from a pyrimidineless strain. One of these mutants consistently yielded a non-Mendelian meiotic segregation. Moreover, the mitotic transmission of the mutation was very high. It is suggested that the mutation is nonchromosomal and could be mitochondrial. However, this mutation behaves very differently from other mitochondrial mutations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Lacroute F. Regulation of pyrimidine biosynthesis in Saccharomyces cerevisiae. J Bacteriol. 1968 Mar;95(3):824–832. [PMC free article] [PubMed]
  • Meuris P, Lacroute F, Slonimski PP. Etude systematique de mutants inhibes par leurs propres metabolites chez la levure Saccharomyces cerevisiae. I. Obtention et caracterisation des differentes classes de mutants. Genetics. 1967 May;56(1):149–161. [PubMed]
  • Mortimer RK, Hawthorne DC. Genetic mapping in Saccharomyces. Genetics. 1966 Jan;53(1):165–173. [PubMed]
  • Roman H, Sands SM. Heterogeneity of Clones of Saccharomyces Derived from Haploid Ascospores. Proc Natl Acad Sci U S A. 1953 Mar;39(3):171–179. [PubMed]
  • Sager R, Ramanis Z. Biparental inheritance of nonchromosomal genes induced by ultraviolet irradiation. Proc Natl Acad Sci U S A. 1967 Sep;58(3):931–937. [PubMed]

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