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This article focuses on the increasing importance of effective communication between basic bench scientists and their colleagues in clinical investigation, and some recent and innovative programs to facilitate these interactions.
When I entered the MD/PhD program at Rockefeller University and Cornell Medical School in 1973, I very naively imagined a future of encountering interesting diseases in the clinic and running to my laboratory to solve mysteries and discover cures by the dozens. It was of course not long before I realized that medicine and research were two separate worlds, and that jumping back and forth between the lab bench and patient’s bedside was not a trivial matter. In fact, in the exciting world of the laboratory of a Nobel laureate (Gerald Edelman, himself an MD/PhD), I fell in love with basic science and began a career that for over twenty years never dealt with a human in a research context, although my work was connected with diabetes. Only in the past ten years did I begin human studies in diabetes, finding a rewarding and productive niche in the world between mouse models and clinical research. Rapidly developing hypotheses using mouse models, testing the hypotheses in humans, and returning to the mouse for mechanistic studies is exhilarating but not always easy. It is increasingly difficult to maintain expertise across a spectrum of research that reaches from molecules to organisms to societies. The tools have increased in complexity, as have the hurdles (regulatory and funding, for example). At the same time, the tools bring with them new possibilities to actually understand and cure disease as could not have been imagined even a few years ago, making this an exciting time to be involved in translational research efforts. This brief article focuses on some of the difficulties of translational research, the crucial importance of training a new generation of scientists that can participate in such research efforts, and new programs that will facilitate such efforts.
Are there in fact problems with translating basic science to the doctor's office or patient's bedside under the current system? There are numerous examples that would suggest the system has worked quite well. For example, pathologists had long observed cholesterol in atheromatous plaques and epidemiologic studies in the 1960's demonstrated associations between serum cholesterol and coronary artery disease. Based on knowledge of the biochemical pathway of cholesterol synthesis and the cell biology of cholesterol transport, inhibitors of HMG-CoA reductase ("statins") came to the market in the 1980's. Subsequent clinical trials revealed efficacy and safety, the public and physicians were appropriately educated, the drugs were widely adopted, and this contributed in a major way to a decrease in mortality from coronary disease. Thus, the entire spectrum of clinical research from basic science to clinical trials, population science and public policy worked together and generated a remarkable success story 1. Numerous similar stories exist wherein basic science knowledge spawned effective therapies such as inhibitors of angiotensin converting enzyme, inhibitors of oncogenic tyrosine kinases 2, insulin derivatives with more favorable pharmacokinetic profiles, and many others.
Although such success stories exist, the complexities of and the specialized expertise required for successful research across the chasm between molecules and populations has multiplied immensely. Thus, it is very difficult in these times to imagine one laboratory, let alone one person, having all of the knowledge to cover the huge gulf between a basic discovery to the development of a disease therapy and its implementation in a community doctor’s office. Furthermore, there exist unique hurdles in translational science that may even become more problematic as our technical prowess increases and outpaces our ability to move the advances in knowledge to therapeutic reality. One answer is to build research teams that span at least sections of the chasm. Alternatively, individuals at various points across the spectrum can be trained to speak the language of investigators who are a step closer than they to the molecular end or the translational end of the spectrum. Thus, even if a formal team does not exist, the investigator at any one point in the continuum will be able to more easily move along the continuum to enlist help at the next stage in the process. A separate need is to create a home for translational investigators where they can more easily access the educational and core support services that are unique to the translation process.
The National Center for Research Resources (NCRR) of the NIH recognized these needs at the beginning of this century and created the Clinical and Translational Science Awards (CTSA, see http://www.ctsaweb.org/). These supplanted the General Clinical Research Centers and instead funded support for a much broader infrastructure for translational investigation, including core support in the areas of biostatistics, translational technologies, study design, community engagement, biomedical informatics, education, ethics and regulatory knowledge, and clinical research units. Forty-six such Centers have been funded, and ultimately sixty are planned. Among the bridging mechanisms for the earlier stages of translation:
Other institutions, such as the Howard Hughes Medical Institute, have also joined in similar efforts. Its “Med into Grad Initiative,” http://www.hhmi.org/grants/institutions/medintograd.html has a goal of bringing medical knowledge and an understanding of clinical practice into the curricula of biomedical Ph.D. programs.
These mechanisms should enhance the translational research enterprise, and efforts of the CTSA consortium have already borne considerable fruit. As team science focused on translation becomes more heavily supported by our government and private foundations, however, new challenges will emerge. Among the many:
Although we face numerous daunting challenges, with the support brought by entities such as the CTSA consortium, there have never been grounds for greater optimism that the most significant health problems of the world can be brought to within reach of complete understanding and even eradication.
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