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THERAPY-HELPER (T-HELPER) is an electronic medical-record system developed at Stanford University that is installed at an AIDS clinic in San Jose, California. The system has been developed using an open, distributed architecture. The T-HELPER workstation supports access by physicians and nurses to online progress notes and hypertext descriptions of ongoing clinical trials. Laboratory and patient-registration data are downloaded automatically from existing hospital information systems. Physicians enter detailed clinical data directly into T-HELPER using a menu-based progress-note system known as IVORY.