PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of procascamcLink to Publisher's site
 
Proc Annu Symp Comput Appl Med Care. 1993 : 492–496.
PMCID: PMC2850626

Probabilistic constraint satisfaction with structural models: application to organ modeling by radial contours.

Abstract

One of the key challenges within medical information sciences is the development of useful models for biological structure and its variability. Many biomedical problems involve the elucidation of structure (for example, from experimental data or from imaging studies), and structural models can often drive the process of inferring precise structure from data. Ideally, model-driven data interpretation combines knowledge about the generic features of a class of biological structures (as contained within a model) with data that provide specific information (often noisy) about a particular instance of the class. In this paper we briefly discuss model-driven determination of biological structure as an example of a structural constraint satisfaction problem. We describe a probabilistic implementation of structural constraint satisfaction, and show that our formulation of a particular organ modeling technology (Radial Contour Models) exhibits promising performance. Our results demonstrate the utility of probabilistic models for the solution of structural constraint satisfaction problems.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Altman RB, Jardetzky O. Heuristic refinement method for determination of solution structure of proteins from nuclear magnetic resonance data. Methods Enzymol. 1989;177:218–246. [PubMed]
  • Arrowsmith C, Pachter R, Altman R, Jardetzky O. The solution structures of Escherichia coli trp repressor and trp aporepressor at an intermediate resolution. Eur J Biochem. 1991 Nov 15;202(1):53–66. [PubMed]
  • Brinkley JF, Altman RB, Duncan BS, Buchanan BG, Jardetzky O. Heuristic refinement method for the derivation of protein solution structures: validation on cytochrome b562. J Chem Inf Comput Sci. 1988 Nov;28(4):194–210. [PubMed]
  • Brinkley JF. Hierarchical geometric constraint networks as a representation for spatial structural knowledge. Proc Annu Symp Comput Appl Med Care. 1992:140–144. [PMC free article] [PubMed]
  • Faber TL, Stokely EM, Peshock RM, Corbett JR. A model-based four-dimensional left ventricular surface detector. IEEE Trans Med Imaging. 1991;10(3):321–329. [PubMed]

Articles from Proceedings of the Annual Symposium on Computer Application in Medical Care are provided here courtesy of American Medical Informatics Association