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Indian J Pharmacol. 2009 December; 41(6): 289.
PMCID: PMC2846508

Authors' reply


It appears from the above discussion that the modulatory role of cytochromes on pioglitazone is doubtful, but numerous evidences has accumulated after the above-cited references that have supported the role of pioglitazone as cytochrome p450 enzyme inducer (although weak).[1,2]

The benefits of ANOVA and post hoc Tuckey can be considered to be equivalent to Chi-square test.


1. Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, et al. Comparative effects of thiazolidinediones on In Vitro P450 enzyme Induction And Inhibition. Drug Metab Dispos. 2003;31:439–46. [PubMed]
2. Ripp SL, Mills JB, Fahmi OA, Trevena KA, Liras JL, Maurer TS, et al. Use of Immortalized Human Hepatocytes to Predict the Magnitude of Clinical Drug-Drug interactions caused by CYP3A4 induction. Drug Metab Dispos. 2006;34:1742–8. [PubMed]

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