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Antimicrob Agents Chemother. 1994 February; 38(2): 337–339.
PMCID: PMC284450

In vivo activity of ajoene against rodent malaria.


Ajoene (4,5,9-trithiadodeca-1,6,11-triene 9-oxide), a product initially isolated from extracts of garlic (Allium sativum), was tested for its antimalarial activity in vivo in a well-characterized murine model. A single ajoene dose of 50 mg/kg, on the day of infection, suppressed the development of parasitemia; there were no obvious acute toxic effects from the tested dose. The combination of ajoene (50 mg/kg) and chloroquine (4.5 mg/kg), given as a single dose on the day of the infection, completely prevented the subsequent development of parasitemia in treated mice.

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Selected References

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  • Apitz-Castro R, Cabrera S, Cruz MR, Ledezma E, Jain MK. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction and platelet ultrastructure. Thromb Res. 1983 Oct 15;32(2):155–169. [PubMed]
  • Apitz-Castro R, Jain MK, Bartoli F, Ledezma E, Ruiz MC, Salas R. Evidence for direct coupling of primary agonist-receptor interaction to the exposure of functional IIb-IIIa complexes in human blood platelets. Results from studies with the antiplatelet compound ajoene. Biochim Biophys Acta. 1991 Sep 24;1094(3):269–280. [PubMed]
  • Apitz-Castro R, Ledezma E, Escalante J, Jorquera A, Pinãte FM, Moreno-Rea J, Carrillo G, Leal O, Jain MK. Reversible prevention of platelet activation by (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide (ajoene) in dogs under extracorporeal circulation. Arzneimittelforschung. 1988 Jul;38(7):901–904. [PubMed]
  • Elmendorf HG, Haldar K. Secretory transport in Plasmodium. Parasitol Today. 1993 Mar;9(3):98–102. [PubMed]
  • Fujioka H, Nishiyama Y, Furukawa H, Kumada N. In vitro and in vivo activities of atalaphillinine and related acridone alkaloids against rodent malaria. Antimicrob Agents Chemother. 1989 Jan;33(1):6–9. [PMC free article] [PubMed]
  • Peters W. The chemotherapy of rodent malaria, XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity. Ann Trop Med Parasitol. 1975 Jun;69(2):155–171. [PubMed]
  • Rendu F, Daveloose D, Debouzy JC, Bourdeau N, Levy-Toledano S, Jain MK, Apitz-Castro R. Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity. Biochem Pharmacol. 1989 Apr 15;38(8):1321–1328. [PubMed]
  • San-Blas G, San-Blas F, Gil F, Mariño L, Apitz-Castro R. Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene. Antimicrob Agents Chemother. 1989 Sep;33(9):1641–1644. [PMC free article] [PubMed]
  • Schapira A, Beales PF, Halloran ME. Malaria: living with drug resistance. Parasitol Today. 1993 May;9(5):168–174. [PubMed]
  • Tansey MR, Appleton JA. Inhibition of fungal growth by garlic extract. Mycologia. 1975 Mar-Apr;67(2):409–413. [PubMed]
  • Tatarintsev AV, Vrzheshch PV, Schegolev AA, Yershov DE, Turgiev AS, Varfolomeyev SD, Kornilayeva GV, Makarova TV, Karamov EV. Ajoene antagonizes integrin-dependent processes in HIV-infected T-lymphoblasts. AIDS. 1992 Oct;6(10):1215–1217. [PubMed]
  • Wernsdorfer WH. The development and spread of drug-resistant malaria. Parasitol Today. 1991 Nov;7(11):297–303. [PubMed]
  • Yoshida S, Kasuga S, Hayashi N, Ushiroguchi T, Matsuura H, Nakagawa S. Antifungal activity of ajoene derived from garlic. Appl Environ Microbiol. 1987 Mar;53(3):615–617. [PMC free article] [PubMed]

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