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Antimicrob Agents Chemother. 1994 January; 38(1): 155–158.
PMCID: PMC284415

Antimicrobial susceptibilities of Neisseria gonorrhoeae strains representing five distinct resistance phenotypes.

Abstract

The susceptibilities of 109 strains of Neisseria gonorrhoeae to penicillin G, tetracycline, amoxicillin-clavulanic acid, cefotetan, cefoxitin, ceftriaxone, ciprofloxacin, and fleroxacin were determined. The activities of cefmetazole, cefuroxime, cefixime, and ofloxacin were also determined against 62 of these strains. Strains represented penicillin-susceptible (Pen(s)) N. gonorrhoeae; penicillinase-producing N. gonorrhoeae (PPNG) possessing 2.9-, 3.05-, 3.2-, or 4.4-MDa beta-lactamase plasmids; strains with high-level, plasmid-mediated tetracycline resistance (TRNG); strains with plasmid-mediated resistance to penicillin and tetracycline; and strains with chromosomally mediated resistance to penicillin and tetracycline (CMRNG). Ceftriaxone, cefixime, and ciprofloxacin were the most active agents tested against all strains. Pen(s), TRNG, and PPNG strains possessing a 3.2-MDa beta-lactamase plasmid were more susceptible to amoxicillin-clavulanic acid, extended- and broad-spectrum cephalosporins, and quinolones than were either PPNG strains possessing a 2.9-, a 3.05-, or a 4.4-MDa beta-lactamase plasmid or CMRNG strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Clendennen TE, Echeverria P, Saengeur S, Kees ES, Boslego JW, Wignall FS. Antibiotic susceptibility survey of Neisseria gonorrhoeae in Thailand. Antimicrob Agents Chemother. 1992 Aug;36(8):1682–1687. [PMC free article] [PubMed]
  • Gorwitz RJ, Nakashima AK, Moran JS, Knapp JS. Sentinel surveillance for antimicrobial resistance in Neisseria gonorrhoeae--United States, 1988-1991. The Gonococcal Isolate Surveillance Project Study Group. MMWR CDC Surveill Summ. 1993 Aug 13;42(3):29–39. [PubMed]
  • Handsfield HH, Hook EW., 3rd Ceftriaxone for treatment of uncomplicated gonorrhea: routine use of a single 125-mg dose in a sexually transmitted disease clinic. Sex Transm Dis. 1987 Oct-Dec;14(4):227–230. [PubMed]
  • Handsfield HH, McCormack WM, Hook EW, 3rd, Douglas JM, Jr, Covino JM, Verdon MS, Reichart CA, Ehret JM. A comparison of single-dose cefixime with ceftriaxone as treatment for uncomplicated gonorrhea. The Gonorrhea Treatment Study Group. N Engl J Med. 1991 Nov 7;325(19):1337–1341. [PubMed]
  • Knapp JS, Holmes KK, Bonin P, Hook EW., 3rd Epidemiology of gonorrhea: distribution and temporal changes in auxotype/serovar classes of Neisseria gonorrhoeae. Sex Transm Dis. 1987 Jan-Mar;14(1):26–32. [PubMed]
  • Putnam SD, Lavin BS, Stone JR, Oldfield EC, 3rd, Hooper DG. Evaluation of the standardized disk diffusion and agar dilution antibiotic susceptibility test methods by using strains of Neisseria gonorrhoeae from the United States and Southeast Asia. J Clin Microbiol. 1992 Apr;30(4):974–980. [PMC free article] [PubMed]
  • Schwarcz SK, Zenilman JM, Schnell D, Knapp JS, Hook EW, 3rd, Thompson S, Judson FN, Holmes KK. National surveillance of antimicrobial resistance in Neisseria gonorrhoeae. The Gonococcal Isolate Surveillance Project. JAMA. 1990 Sep 19;264(11):1413–1417. [PubMed]
  • Whittington WL, Knapp JS. Trends in resistance of Neisseria gonorrhoeae to antimicrobial agents in the United States. Sex Transm Dis. 1988 Oct-Dec;15(4):202–210. [PubMed]
  • Zenilman JM, Whittington WL, Frazier D, Rice RJ, Knapp JS. Penicillinase-producing Neisseria gonorrhoeae in Dade County, Florida: phenotypic characterization of isolates from 1983, 1984, and 1986. Sex Transm Dis. 1988 Jul-Sep;15(3):158–163. [PubMed]

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