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Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): Virological synapse-mediated spread of human immunodeficiency virus. Electron tomography and surface rendering reveals the three-dimensional (3D) morphology of a synapse that is formed between an HIV-1-infected Jurkat donor T cell (blue) and an uninfected primary target T cell (yellow). A large number of HIV-1 virions (red) are seen at the interface of the two cells. The interface displays multiple membrane invaginations and projections, but it appears loosely structured. The plasma membranes are relatively distant over most of the synapse, punctuated by limited areas of close membrane apposition. The image shows a digital slice from a stack of four serial reconstructions of epoxy resin-embedded 300-nm cell sections. The digital slice is overlaid with the colored 3D surface renderings of cells and virus from the same stack. (See related article on p. 3516.)

J Virol. 2010 April; 84(7): Cover