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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Mol Cell Endocrinol. Author manuscript; available in PMC 2010 April 29.
Published in final edited form as:
Mol Cell Endocrinol. 2009 April 29; 302(2): 148–158.
Published online 2008 November 18. doi: 10.1016/j.mce.2008.11.003

Figure 3

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Role of ROS in contraction induced by angiotensin II in vascular smooth muscle cells

ROS production is implicated in calcium dependent and independent induced by angiotensin II. Red lines show inhibitory effects and blue lines depict activation. ROS (reactive oxygen species), AT1R (angiotensin II receptor type 1), PLC (phospholipase C), PIP2 (phosphoinositol biphosphate), IP3 (inositol 1,4,5 triphosphate), IP3R (inositol 1,4,5 triphosphate receptor), SERCA (sarco/endoplasmic reticulum Ca2+-ATPase), GEF (guanine nucleotide exchange factor), GTP (guanosin triphosphate), ROCK (Rho-associate kinase) and MLC (myosin light chain).

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