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[Cover image of issue]

Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): Crystal structure of Clostridium acetobutylicum ATCC 824 EG. A TIM barrel, a β-sandwich domain (bottom), and a ψ-loop domain (top) are shown. The catalytic acid/base, Glu180, and catalytic nucleophile, Glu352, are shown as sticks, as are amino acid residues involved in ligand binding. A chloride ion (left ball) is located next to the catalytic acid/in the TIM barrel, and a calcium ion (right ball) stabilizes the ψ-loop. (See related article in January 2010, vol. 76, no. 1, page 338.)

Appl Environ Microbiol. 2010 February; 76(4): Cover