Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t½ of the above antibiotics in animal model.
Keywords: Ampicillin, Bioavailability, Norfloxacin, Phamacokinetics, Piperine, Piper nigrum