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Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): Model of antibody 2F5 (Fab, in yellow) approaching the membrane-proximal external region (MPER) of the HIV-1 surface envelope spike. The molecular surface representation of the putative gp120 trimer shown is based on a combination of the spike cryo-ET from Subramaniam and colleagues, the core gp120 and 2F5 crystal structures from Kwong and colleagues, and the spike glycans modeled by Schief and colleagues. The gp41 stalk exposed above the viral surface membrane is an artistic impression. MPER antibodies have evolved to bind highly conserved hydrophobic linear epitopes exposed near the viral membrane surface, and some, including 2F5, have been shown to completely protect against SHIV mucosal challenge. Graphic design by Christina Corbaci. (See related article in February 2010, vol. 84, no. 3, p. 1302.)

J Virol. 2010 February; 84(4): Cover