We thank Maria de Iorio, PhD and Pimphen Charoen, MPhil (Imperial College London) for help with the statistical analyses. Individuals acknowledged here by name were not compensated for their contributions to this paper.
Funding and support. With the exception of GlaxoSmithKline, whose scientists were involved in the planning, data collection and analysis for the GEMS and CoLaus studies, funders had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review or approval of the manuscript.
DESIR study. DESIR has been supported by INSERM, CNAMTS, Lilly, Novartis Pharma and Sanofi-Aventis, the Association Diabète Risque Vasculaire, the Fédération Française de Cardiologie, La Fondation de France, ALFEDIAM, ONIVINS, Ardix Medical, Bayer Diagnostics, Becton Dickinson, Cardionics, Merck Santé, Novo Nordisk, Pierre Fabre, Roche, Topcon. We acknowledge funding to PF by the European Union (Integrated Project EURODIA LSHM-CT-2006-518153 in the Framework Programme 6 [FP06] of the European-Community).
Detailed information on the GEMS study design, sampling frame, and recruitment procedures has been published previously.15
We acknowledge the work of the GEMS investigators: Camperdown, Sydney, NSW, Australia (Prof. P. Barter, Ph.D.); Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland (Prof. Y. A. Kesäniemi, Ph.D.); Gladstone Institute of Neurological Disease and Gladstone Institute of Cardiovascular Disease, San Francisco, CA, U.S.A. (Prof. R. W. Mahley, Ph.D.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (Prof. R. McPherson, F.R.C.P.); Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A. (Prof. S. M. Grundy, Ph.D.); G.W. was also a GEMS investigator. The study was sponsored in part by GlaxoSmithKline, and all participants were duly informed about this sponsorship, and consented for the use of biological samples and data by GlaxoSmithKline and its subsidiaries; the study was approved by the local ethics committees.
German MI Family Study. The study was supported by grants from the Deutsche Forschungsgemeinschaft and the Deutsche Herzstiftung, the National Genome Research Network 2 of the German Federal Ministry of Education and Research, and the Cardiogenics project of the European Union.
INTERHEART Study. SSA holds the Michael G. DeGroot and Heart and Stroke Foundation of Ontario Chair in Population Health and the May Cohen Eli Lilly Endowed Chair in Women's Health Research, McMaster University. JCE is a research scholar of the Fonds de la Recherche en Santé du Québec. We thank Ron Do, MSc for help with statistical analyses. We acknowledge the contribution of Prof Salim Yusuf who initiated and together with the Steering Committee members, supervised the conduct of the INTERHEART study. We acknowledge all of the clinical centres in INTERHEART which are named in the INTERHEART 2004 report. We thank the members of the project office of the Population Health Research Institute, Sumathy Rangarajan and Laura Joldersma (study coordination), and Changchun Xie PhD (statistical support). The INTERHEART study was funded by the Canadian Institutes of Health Research, the Heart and Stroke Foundation of Ontario, the International Clinical Epidemiology Network (INCLEN), and through unrestricted grants from several pharmaceutical companies (with major contributions from AstraZeneca, Novartis, Sanofi Aventis, Knoll Pharmaceuticals [now Abbott], Bristol Myers Squibb, and King Pharma), and by various national bodies in different countries Chile: Universidad de la Frontera, Sociedad Chilena de Cardiologia Filial Sur; Colombia: Colciencias, Ministerio de Salud; Croatia: Croatian Ministry of Science & Technology; Guatemala: Liga Guatemalteca del Corazon; Hungary: Astra Hassle, National Health Science Council, George Gabor Foundation; Iran: Iran Ministry of Health; Italy: Boehringer-Ingelheim, Japan: Sankyo Pharmaceutical Co., Banyu Pharmaceutical Co., Astra Japan; Kuwait: Endowment Fund for Health Development in Kuwait; Pakistan: ATCO Laboratories; Philippines: Philippine Council for Health Research & Dev., Pfizer Philippines Foundation, Inc., Astra Pharmacetuicals, Inc. & the Astra Fund for Clinical Research & Continuing Medical Education, Pharmacia & Upjohn Inc.; Poland: Foundation PROCLINICA; Singapore: Singapore National Heart Association; South Africa: MRC South Africa, Warner-Parke-Davis Pharmaceuticals, Aventis; Sweden: Grant from the Swedish State under LUA Agreement, Swedish Heart and Lung Foundation; Thailand: The Heart Association of Thailand, Thailand Research Fund. This project was supported by the ECOGENE-21 project from the Center for Applied Health Research (CAHR) program (grant CAR43283).
We gratefully acknowledge the patients and their relatives who collaborated, their general practitioners, and the medical and nursing staff from more than 100 hospitals in the U.K. A full list of the participating centers and collaborators is given in the ISIS-3 report.19
The ISIS trials and epidemiological studies were supported by the manufacturers of the study drugs, and by the British Heart Foundation, Medical Research Council, Cancer Research UK, Tobacco Products Research Trust of the UK Department of Health Independent Scientific Committee on Smoking and Health, and Oxford NHS Genetic Knowledge Park.
Lausanne Cohort (CoLaus) study. Investigators: Jacques S Beckmann, Sven Bergmann, Murielle Bochud, Toby Johnson, NL, VM, Kijoung Song, PV, GW, DMW, Xin Yuan. Principal Investigators: VM, PV. Study design: JSB, VM, PV, GW, DMW. Assembly of the cohort: GW Data analysis: NL. Project management: JSB, SB, MB, VM, PV, DMW. TJ was supported by the Giorgi-Cavaglieri Foundation. JSB was supported by UNIL. SB is supported by the Giorgi-Cavaglieri Foundation and the Swiss National Science Foundation (Grant # 3100AO-116323/1). MB was supported by the Swiss National Science Foundation. PV and GW received financial support from GlaxoSmithKline to build the CoLaus study. This work has been supported by GlaxoSmithKline and the Faculty of Biology and Medicine of Lausanne, Switzerland.
London Life Sciences Population (LOLIPOP) study. Investigators: JCC, PE, JS, JSK. Principal investigator: JSK. Data analysis: JCC, WZ, Delilah Zabeneh, Robin Walters, Maria de Iorio, David Balding. LOLIPOP is supported by the British Heart Foundation Grant SP/04/002.
North Finland Birth Cohort of 1966. Investigators: PE, NBF, Anna-Liisa Hartikainen, M-RJ, MIM, LP, Anneli Pouta. Data analysis: LC, Pimphen Charoen. Biochemical Analysis: AR. We acknowledge the support of NHLBI grant 5R01HL087679-02 through the STAMPEED program, the MRC of the UK, EURO-BLCS, QLG1-CT-2000-01643, Biocenter of University of Oulu, and Academy of Finland, and NIMH grant 1RL1MH083268-01.
Investigators: RC, MF, Anuj Goel, AH, Simon C Heath, G Mark Lathrop, JFP, Udo Seedorf, Ann-Christine Syvänen, Giovanni Tognoni, H.W. Principal investigator for project: HW. Principal investigators for collection centre: RC, AH, US, GT. Genotyping: SCH, GML, A-CS. Quality control: SCH. Data analysis: MF, AG, JFP. Project management: JFP, HW. See www.procardis.org
for full membership of PROCARDIS consortium. We are grateful to the participants and to the medical and nursing staff who assisted in this project. This work was funded by the British Heart Foundation, EC Sixth Framework Programme (LSHM33 CT- 2007- 037273), AstraZeneca AB and the Knut and Alice Wallenberg Foundation.
WTCCC-CAD. Recruitment for the WTCCC study was supported by grants from the British Heart Foundation and the UK Medical Research Council. We also acknowledge support from the Wellcome Trust Functional Genomics Initiative in Cardiovascular Genetics. Dr. Samani holds a chair funded by the British Heart Foundation.