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[Cover image of issue]

Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): Severe acute respiratory snydrome (SARS) coronavirus infection induces a reticulovesicular network (RVN) of modified endoplasmic reticulum (ER) associated with the viral replication and transcription complex (RTC). Following brefeldin A (BFA) treatment, all normally encountered substructures were observed, including double-membrane vesicles and vesicle packets (outer membranes, dark blue; inner membranes, dark green) and convoluted membranes (lavender), suggesting that the cell's early secretory pathway is not directly involved in RVN/RTC formation or function. The image shows a 3-D surface-rendered electron tomography model of the RVN in a BFA-treated, infected cell against a background of mitochondria (M, red) and BFA-induced dilated ER and tubulovesicular clusters (depicted in light blue and pink, respectively). The model was superimposed on a 0°-tilt image of a 200-nm-thick resin-embedded section. (See related article on p. 833.)

J Virol. 2010 January; 84(2): Cover