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Cancer. Author manuscript; available in PMC Jun 15, 2010.
Published in final edited form as:
PMCID: PMC2796482
NIHMSID: NIHMS113304
The Effect of Modafinil on Cognitive Function in Breast Cancer Survivors
Sadhna Kohli, PhD, MPH,1 Susan G. Fisher, PhD,2 Yolande Tra, PhD,3 M. Jacob Adams, MD, MPH,2 Mark E. Mapstone, PhD,4 Keith A. Wesnes, PhD,5 Joseph A. Roscoe,6 and Gary R. Morrow, PhD, MS6
1Department of Medicine and Radiation Oncology, James. P. Wilmot Cancer Center, University of Rochester, Rochester School of Medicine and Dentistry, Rochester, New York
2Department of Community and Preventive Medicine, University of Rochester, Rochester School of Medicine and Dentistry, Rochester, New York
3School of Mathematical Sciences, Rochester Institute of Technology, Rochester, NY
4Department of Neurology, University of Rochester, Rochester School of Medicine and Dentistry, Rochester, New York
5Cognitive Drug Research Ltd., Goring-on-Thames, UK
6Department of Radiation Oncology, James. P. Wilmot Cancer Center, University of Rochester, Rochester School of Medicine and Dentistry, Rochester, New York
CORRESPONDING AUTHOR: Sadhna Kohli, PhD., MPH, Mayo Clinic, 200 First St SW, Rochester, MN 55905. kohli.sadhna/at/mayo.edu
Objective
We conducted a randomized clinical trial examining the effects of modafinil in reducing persistent fatigue in patients following treatment for cancer and performed secondary analyses to assess the effect of modafinil on cognitive function.
Methods
Breast cancer patients who reported a score of ≥ 2 on the Brief Fatigue Inventory (BFI) were enrolled in the study. In Phase 1 (P1), patients received 200mg modafinil open-label once daily for 4 weeks. In Phase 2 (P2), patients with a positive response following P1 were randomized either to an additional 4 weeks of modafinil or to placebo. Tests of memory and attention selected from the Cognitive Drug Research (CDR) computerized cognitive assessment were performed at baseline (before modafinil) and after completing Phase 1 and 2. The paired differences for each test score were subjected to a Wilcoxon's signed rank test.
Results
Of the 82 women who were enrolled, 76 completed P1 and 68 completed all assessments in the study. Modafinil had a significant effect on the Speed of Memory (p=0.0073) and Quality of Episodic Memory (p<0.0001) during P1 of the study. After randomization at week 8, those patients who continued modafinil demonstrated significantly greater improvement in Speed of Memory (p=0.029), Quality of Episodic Memory (p=0.0151) and mean Continuity of Attention (p=0.0101) relative to the group switched to placebo.
Conclusion
We found that modafinil improved cognitive performance in breast cancer survivors by enhancing some memory and attention skills. Although confirmation is needed, these findings suggest that modafinil may enhance quality of life in this patient population.
Keywords: modafinil, cognitive function, memory, attention, breast cancer
Following cancer treatment, some breast cancer survivors report cognitive impairment, which has commonly been attributed to the receipt of chemotherapy and colloquially termed “chemobrain” (1). Cognitive deficits identified by cancer survivors consist of a range of difficulties including memory and concentration problems that can emerge during cancer treatment and continue to have long-term effects for many months and years after its completion (2-8). Impairment of brain function profoundly affects cognition, psychological well-being, and the ability to perform the usual activities of daily living.
Changes in cognitive function may be confused with or confounded by other problems commonly associated with cancer and its treatment, such as depression, anxiety, and fatigue caused by sleep deprivation (9-11). Although the phenomenon is not understood completely, cognitive deficits in cancer patients are assuming greater significance as cancer survival improves. Advances in basic sciences, imaging, and clinical sciences are beginning to unravel pathophysiologic mechanisms which may underlie this problem (12). Pharmacologic treatment options for cognitive deficits in cancer survivors are borrowed from diverse diseases including attention-deficit/hyperactivity disorder and neurodegenerative diseases (13, 14). Conventional therapies soon may find new applications; for example, recent preclinical data suggest that modafinil (Provigil®) may have some cognitive-enhancing abilities, which may positively affect patients who experience “chemobrain”.
Modafinil is a novel wake-promoting agent that is effective and well tolerated in the treatment of excessive sleepiness associated with narcolepsy and in persons with shift-work sleep disorder (15-19). The precise mechanism(s) through which modafinil promotes wakefulness is unknown. Modafinil has wake-promoting actions like those of sympathomimetic agents including amphetamine and methylphenidate, although the pharmacologic profile of modafinil is not identical to that of the sympathomimetic amines. The recommended single daily dose range for narcolepsy is 100-400mg modafinil (Provigil®). These doses have wake-promoting efficacy comparable to 20-40mg doses of methylphenidate (20), which has been used previously in cognitive studies in patients with advanced cancer (21).
We completed a study examining the effect of modafinil on fatigue and sleep complaints in 82 breast cancer patients following completion of chemotherapy (22). Patients received 200 mg modafinil once daily for one month. Of the 82 women enrolled, 76 completed the study and began the study medication. A majority, 68 of the 76 women (90%) who completed the one-month study, reported improvement on all four measures of fatigue used (23-26), all p < 0.001 (Figure 1). In addition, the Epworth Sleepiness Scale showed a 22% decrease (p < 0.01), and the “disturbed sleep” symptom on the symptom inventory (27) decreased more than 45% (p < 0.01).
Figure 1
Figure 1
Fatigue levels in post-treatment breast cancer patients receiving open-label modafinil (22).
Despite these findings, little is known about the causes of cognitive changes seen during and after cancer treatment. It seems reasonable to assume that they are related, at least in part, to other psychological and biological treatment complaints such as fatigue, sleeping problems and depression (10, 28). The nature of the relationships among these variables, however, both at onset and over time remains unclear.
To our knowledge, in spite of evidence that modafinil acts as a cognitive enhancer in healthy subjects (29-31), no study to date has examined the effect of modafinil on a wide range of cognitive functions using a comprehensive and well-validated neuropsychological test battery in cancer patients. Therefore, as modafinil was effective in reducing persistent fatigue in our primary study (22), we conducted secondary analyses to assess the effect of modafinil on cognitive function and to examine whether modafinil might act as a cognitive enhancer in breast cancer patients who have completed treatment for cancer.
General study procedures
Eighty-two breast cancer patients between the ages of 33 and 83 years, who were more than one-month post-chemotherapy and/or radiation treatment for an initial diagnosis of cancer, able to swallow medication, and had a score of 2 or greater on a Brief Fatigue Inventory (BFI) (25) question of “fatigue worst”, and who completed participation in the primary study “Modafinil to Treat Persistent Fatigue in Patients Following Treatment for Cancer (22)” are included in this secondary analysis. These patients were approached for the primary study by their medical oncologist either at a regularly scheduled appointment at the Medical Oncology clinic at the University of Rochester NY, by telephone or a standardized letter in the mail. It was explained to the patients that fatigue is a subjective symptom with individual meaning which may be described using a variety of words and phrases such as “weak and tired,” “no energy,” “can't get motivated,” or “trouble breathing” (32). The patient then completed question 3 of the BFI. If the patient responded to question 3 of the BFI with an answer of 2 or greater than 2, the patient was invited to participate in the study, however, if the patient responded with an answer of 1, the patient was considered ineligible for the study. The University of Rochester Research Subjects Review Board approved the primary study, and all patients provided written informed consent.
In Phase 1 of the study, patients received one tablet of 100mg of modafinil once a day for the first three days and then two tablets (200mg) open-label once daily for 4 weeks. In Phase 2, patients with a positive response following Phase 1 were randomized either to an additional 4 weeks of modafinil (200mg) or to placebo. Tests of memory and attention selected from the Cognitive Drug Research (CDR) computerized cognitive assessment were performed at baseline (before modafinil) and after completing Phase 1 and 2.
Potential research subjects were excluded if they had taken modafinil previously, had taken a psychostimulant or a monoamine oxidase inhibitor within the past 30 days, or were currently taking an anticoagulant, α-interferon, interleukin-2, or a corticosteroid. Individuals with a history of clinically significant cardiac disease, uncontrolled hypertension, alcohol or drug abuse, severe headaches, glaucoma, seizure disorder, narcolepsy, psychotic disorder, or uncontrolled Tourette's syndrome were also excluded. If a steroidal contraceptive was being used for fertility control, participants had to agree to use a barrier method of contraception during the study and for one full menstrual cycle following the study.
Randomization
After four weeks of open-label modafinil, patients who met the eligibility criteria were randomized to one of two trial arms by means of randomly ordered sealed envelopes. Participants were stratified by treatment regimen (completed chemotherapy alone or radiation alone or chemotherapy plus radiation) and were assigned to either continue 200mg modafinil orally once each day or switch to a matching placebo orally once each day.
Assessments
The Cognitive Drug Research (CDR) system was used to assess major domains of attention and memory. The CDR system is designed to provide the drug development process with a stable, practical, validated and sensitive platform to enable important cognitive and behavioral effects of medicines to be captured and evaluated. Its validity, test-retest reliability and sensitivity have been demonstrated in several populations (33-36).
The CDR system comprises both custom-built tests (e.g. digit vigilance, spatial working memory) plus tests whose general methodology is widely known (simple and choice reaction time, word recall). All tests have been standardized, extensively validated, and implemented with a software and hardware platform which enables responses to be recorded with true millisecond accuracy.
The system has been used worldwide since 1984 in over 500 clinical trials. Data from the system have been the subject of over 100 peer-reviewed papers, more than 20 chapters, and 300 published abstracts (37). An advantage of the CDR system is that many of the tests used are generic and generally accepted for use in psychopharmacology research. Further, because it has been used in hundreds of studies, extensive normative data exists from populations ranging in age from 12 to 90 years.
In recent years CDR has identified major factors reflecting distinct and important dimensions of human cognitive function. The measures which contribute to these factors are combined to produce factor scores. These factor scores are unique to the CDR system and thus the CDR offers a highly sensitive way of assessing broad but distinct aspects of cognitive function.
The sensitivity and reliability of these tests for detecting cognitive impairment in a variety of clinical conditions (e.g., normal aging, depression, post stroke, schizophrenia, and attention deficit disorder, all of the major dementias, head trauma, and drug-induced cognitive changes) have been demonstrated (38-45). The CDR battery is sensitive to treatment effects, including pharmacologic therapies (44-53).
Table 1 shows a summary of the measures contributing to the analyses of the Cognitive Drug Research (CDR) computerized assessment system.
Table 1
Table 1
Measures Contributing to the Analyses of the Cognitive Drug Research (CDR) Computerized Assessment System
Statistical Analysis
The main objective of this study was to evaluate the efficacy of modafinil in alleviating cognitive impairment in cancer patients following completion of cancer therapy. Power calculations demonstrated that with our sample size of 34 subjects in each group, we would be able to detect an effect size of 0.62 standard deviations, using a two-sided p-value of < 0.05 for statistical significance. If the standard deviation of the change score was 1, then the difference of change score detected was 0.62; if the standard deviation was 2, then the difference detected was 2×0.62, with a power of 0.939. The primary independent variable was treatment group, and the dependent variable was the change in scores after randomization (week 4 to week 8). The primary outcome measures chosen for these comparisons were the change in the factor scores of Speed of Memory and Continuity of Attention with the rationale that those patients who experience “chemobrain”, self-report problems with their memory and concentration (54), and to investigate whether these outcomes may prove sensitive to modafinil. Differences in assessment scores using paired samples from baseline (week 0) to randomization (week 4) and baseline to post-treatment (week 8) were also compared across the entire study sample. If the distribution of the differences between pairs was non-normally distributed, the Wilcoxon's signed rank test was used to assess the change within each treatment group. All statistical tests were two-sided and performed at the 5% level of significance. Data analysis was performed using SAS software version 9.1 (SAS Institute, Cary, North Carolina, USA).
Subject characteristics
Of the 82 eligible patients, six dropped out before completing the open-label phase: two complaining of anxiety, two reporting headaches, and one reporting nausea dropped out during the first week (all were very slight with weights under 110 lbs), while a final patient found herself unexpectedly pregnant midway through the study and was withdrawn (Figure 2). The characteristics of the six participants who did not complete all assessments during randomization were very similar to those who did complete the study. The six patients were white, and most had received some college education. Most adverse events were considered by the investigator to be mild or moderate in severity (defined as no or some limitation of usual activities), occurred with greatest frequency during the first two weeks of open-label therapy, and were self-limited.
Figure 2
Figure 2
Patients who completed study at each time-point.
Seventy-six breast cancer survivors completed the one month open-label study (age range=33-83 years, median age =54 years). These women were Caucasian (n=74, 97%), married n=51, (67%), had at least some college education (n=57. 75%), and the majority (n=45, 59%) were employed in professional occupations. All subjects had been treated with surgery and chemotherapy with 65 (86%) also receiving radiation therapy.
Upon assessment at week 4, an additional eight patients failed to meet the eligibility criteria to continue onto the randomization phase of the study, because they showed no improvement in fatigue during the open-label phase. The remaining 68 (83%) survivors were randomized, and they all fully completed the assessments—open-label and randomization—between weeks 0 and 8 of the study. These 68 are included in these analyses. Baseline descriptive data for both the open-label phase and drug and placebo groups following randomization are shown in Table 2.
Table 2
Table 2
Patient Demographic and Clinical Characteristics
The connection between aging and cancer is significant; more than 60% of all cancers occur among those over age 65. There is little information regarding the effect of adjuvant chemotherapy on the older patient's cognitive abilities and whether the chemotherapy affects the patient's ability to maintain functional independence (55). The modafinil group mean age was five years younger than the placebo group in this analysis, however, independent t-tests revealed no statistically significant differences in age (P=0.066), education (P=0.921) or occupation (P=0.182) between the two randomized groups: modafinil (N=34) and placebo (N=34). Finally, we examined differences in fatigue and depression between the groups. In previous research, both fatigue and depression have demonstrated a potential to affect cognitive performance. However, no statistically significant differences between drug and placebo groups were observed for these variables (fatigue p=0.21 and depression p=0.46).
Analyses
Cognitive Drug Research (CDR) battery
Overall results of the CDR composite mean scores are summarized in Table 3.
Table 3
Table 3
Summary of composite scores* from CDR assessments across treatment groups during open label and randomization.
Open-label (week 0 to week 4)
In this study of 68 participants, the analysis of the primary outcome factor, the Speed of Memory Index, revealed a significant effect of modafinil (mean change=240.003 seconds, p=0.0073,). This index was computed as a combination of four factors which included speed of numeric working memory, speed of spatial working memory, speed of word recognition and speed of picture recognition (Figure 3). There was also a statistically significant effect of modafinil on the Digit Vigilance test (one of the measures in Continuity of Attention; mean change 1.623 units, p=0.0014,) during the four weeks of modafinil therapy. However, modafinil produced no significant effect on the composite Continuity of Attention (p=0.0568).
Figure 3
Figure 3
Mean change from baseline for Quality of Episodic Memory and Speed of Memory During Open-Label (N=76)
Three measures— immediate word recall (mean change 8.59375, p<0.001), word recognition accuracy (mean change 6.985 units, p=0.0002), picture recognition accuracy (mean change -138.281 seconds, p= 0.0054) in Quality of Episodic Secondary Memory also showed a statistically significant mean improvement from baseline to week 4. Overall, significant improvement was observed in Quality of Episodic Secondary Memory (mean change 26.826 units, p<0.0001) from baseline to week 4 (figure 3).
Modafinil showed no effect on Quality of Working memory (p=0.2475) nor on Power of Attention (p=0.9031) in the open-label phase.
Randomization (drug vs. placebo, week 4 to week 8)
Randomization did not have a significant effect on each outcome measure of any one factor score. However, modafinil demonstrated a cumulative improvement from baseline to week 8 in composite Speed of Memory scores (p=0.029) compared to placebo (p=0.116) and for composite Quality of Episodic Secondary Memory, the scores in the drug group show significant change (p=0.015) compared to the placebo group (p=0.155). Improvement was observed at the week 4 visit and was maintained throughout the study.
About 70% of the subjects in the active drug group had an improvement in Continuity of Attention from baseline to post-treatment (week 8), compared to 52% in the placebo group, but the difference was not significant (p=0.19). The active drug produces a better response, an improvement over the week 4 assessment where no significant effect was seen (Figure 4). At the final visit (week 8), mean Continuity of Attention improved for the modafinil group (p=0.010) compared with placebo (p=0.54).
Figure 4
Figure 4
Cumulative Improvement in Continuity of Attention (Week 0 to 8)
There was no significant effect of modafinil on Quality of Working Memory or Power of Attention during the randomization phase.
This secondary analysis has some limitations. The patients in this study tended to be more educated than the general population and were primarily Caucasian, making these results less generalizable to patients from minority groups or those of lower socioeconomic status. In addition, the original study recruited 82 breast cancer patients, but for the purpose of this study, we have only analyzed data from the 68 patients who completed all three CDR assessments. Although this reduction in patient numbers may have resulted in a biased subsample, it should be remembered that patients were not randomized if they failed to respond to open-label modafinil in terms of the primary outcome of the original study—i.e., fatigue, not cognitive improvement. Furthermore, as Table 1 demonstrates, the 68 completers did not appear to differ from the 76 individuals who had no side effects, and the purpose of this secondary analysis is to determine whether sufficient evidence indicates that modafinil improves cognitive function to support further trials to demonstrate this result more conclusively. For a future study, we propose a longitudinal design whereby patients are recruited prior to chemotherapy and randomized to modafinil or placebo, and cognitive performance is evaluated before chemotherapy and again three and six month's post-chemotherapy. This strategy would directly establish the presence of cognitive deficits related to chemotherapy and determine whether modafinil alleviated those deficits.
Modafinil is a wakefulness- and alertness-enhancing agent currently approved for treatment of excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift-work sleep disorder. Modafinil belongs to a class of drugs called eugeroics (meaning “good arousal”). Its uniqueness lies in its ability to only “stimulate when stimulation is required” (56). As a result, the “highs and lows” associated with other stimulants such as amphetamine, are absent with eugeroics. Modafinil appears to produce its effects via different neural mechanisms than conventional stimulants or other psychotrophic drugs with similar effects on wakefulness and alertness, and it does not seem to stimulate dopamine transmission in the brain or produce sympathomimetic effects. Although the precise mechanism of action of modafinil is unknown, numerous human and animal studies have elucidated many of its characteristics. Modafinil has site-specific central nervous system activity (57, 58) and acts on a specific subset of brain pathways that regulate sleep and wakefulness. However, it does not bind to many receptors that are normally involved in sleep/wake regulation, including those for norephinephrine, serotonin, dopamine and γ-aminobutyric acid. It does not have the effects on the extrapyramidal motor system—restlessness, hyperactivity, and irritability—that conventional stimulants exhibit, suggesting that modafinil has the potential to act as a cognitive enhancer without the side-effects produced by other stimulants.
This study of modafinil, the first to examine cognitive function in patients following treatment for cancer, has demonstrated that 200mg of modafinil enhances Speed of Memory making patients both more accurate and faster at retrieving information. Although modafinil had no significant effect at week 4 on Continuity of Attention, those participants who continued modafinil showed an improvement at week 8. Significant improvement was also seen in the Quality of Episodic Secondary Memory, indicating that patients treated with modafinil were better able to store, retain, and retrieve both verbal and pictorial information. Modafinil was thus able to improve cognitive performance (memory and attention) in chemotherapy-treated breast cancer survivors.
Most of the effects of modafinil on the composite score of memory and some measures in attention were shown in the first post-baseline visit (week 4) and were sustained throughout the study and are similar to those previously noted in clinical studies of modafinil in other populations (59-62). The findings of this study demonstrate that the duration of an open-label drug is an important factor that needs to be addressed when considering a pharmacological intervention for a symptom. By commencing all our patients on 200mg daily of modafinil and then dividing them into two groups where one group continued the medication and the other started taking an identical placebo, we were able to compare four weeks of modafinil treatment with eight weeks.
Quality of life, as well as survival and potential for cure, is of paramount importance to cancer patients. Post-treatment survivorship issues have become a prominent concern in cancer survivors and patients living with cancer. Cancer therapy-related cognitive decline, along with fatigue, anxiety, and depression, is one of the most common symptoms affecting quality of life (63, 64). During the past decade, studies have been performed to define this treatment-related cognitive decline and to study its prevalence and importance. Unfortunately, the precise etiology remains obscure for most patients with this debilitating side-effect. A better molecular understanding of this cognitive dysfunction will likely lead to the identification of therapeutic targets and ultimately better treatment.
Although larger studies are needed to confirm these findings, the results of our secondary analysis of a trial of modafinil suggest that it can considerably improve some cognitive function measures in breast cancer survivors.
Acknowledgements
The authors are indebted to all the volunteers for participation and to Cephalon, Inc., for providing the study drug. The study was supported by a grant from Cephalon, Inc., and NCI Grants U10-CA37420 and R25-CA102618.
The study was supported by a grant from Cephalon, Inc and NCI Grants U10-CA37420 and R25-CA102618.
1. Huria A, Somlo G, Ahles T. Renaming “Chemobrain” Cancer Invest. 2007 Sep;25(6):373–7. [PubMed]
2. Wieneke MH, Dienst ER. Neuropsychological assessment of cognitive functioning following chemotherapy for breast cancer. Psychooncology. 1995;4:61–66.
3. Van Dam FS, Schagen SB, Muller MJ, et al. impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: High-dose versus standard-dose chemotherapy. J Natl Cancer Inst. 1998;90:210–218. [PubMed]
4. Schagen SB, van Dam FS, Muller MJ, et al. Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma. Cancer. 1999;85:640–650. [PubMed]
5. Brezden CB, Phillips KA, Abdolell M, et al. Cognitive function in breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol. 2000;18:2695–2701. [PubMed]
6. Kreukals BP, Van Dam FS, Ridderinkhof KR, Boogerd W, Schagen SB. Persistent Neurocognitive Problems after Adjuvant Chemotherapy for Breast Cancer. CLIN Breast Cancer. 2008 Feb;8(1):80–7. [PubMed]
7. Ferguson RJ, Ahles TA. Low Neuropsychologic Performance Among Adult Cancer Survivors Treated With Chemotherapy. Curr Neuro and Neurosc Rep. 2003;3:215–222. [PubMed]
8. Castellon SA, Ganz PA, Bower JE, et al. Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen. J Clin Exp Neuropsychol. 2004;26:955–969. [PubMed]
9. Mehnert A, Scherwath A, Schirmer L, Schleimer B, Petersen C, Schultz-Kindermann F, Zander AR, Koch U. The association between neuropsychological impairment, self-perceived cognitive deficits, fatigue and health related quality of life in breast cancer survivors following standard adjuvant versus high-dose chemotherapy. Patient Education and Counseling. 2007 April;66(Issue 1):108–118. [PubMed]
10. Bower JE. Behavioral symptoms in patients with breast cancer and survivors. J Clin Oncol. 2008 Feb 10;26(5):768–77. [PMC free article] [PubMed]
11. Janz NK, Mujahid M, Chung LK, Lantz PM, Hawley ST, Morrow M, Schwartz K, Katz SJ. Symptom experience and quality of life of women following breast cancer treatment. J Womens Health (Larchmt) 2007 Nov;16(9):1348–61. [PubMed]
12. Miller AH, Ancoli-Israel S, Bower JE, Capuron L, Irwin MR. Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. J Clin Oncol. 2008 Feb 20;26(6):971–82. [PMC free article] [PubMed]
13. Mar Fan HG, Clemons M, Xu W, Chemerynsky I, Breunis H, Braganza S, Tannock IF. A randomised, placebo-controlled, double-blind trial of the effects of d-methylphenidate on fatigue and cognitive dysfunction in women undergoing adjuvant chemotherapy for breast cancer. Support Care Cancer. 2008 Jun;16(6):577–83. [PubMed]
14. Nelson CJ, Nandy N, Roth AJ. Chemotherapy and cognitive deficits: mechanisms, findings, and potential interventions. Palliat Support Care. 2007 Sep;5(3):273–80. Review. [PubMed]
15. US Modafinil in Narcolepsy Multicenter Study Group Randomized trial of modafinil for the treatment of pathological somnolence of narcolepsy. Ann Neurol. 1998;43:88–97. [PubMed]
16. US Modafinil in Narcolepsy Multicenter Study Group Randomized trial of modafinil for the treatment of pathological somnolence of narcolepsy. Neurology. 2000;54:1166–75. [PubMed]
17. Broughton RJ, Fleming JA, George CF, et al. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology. 1997;49:444–51. [PubMed]
18. Moldofsky H, Broughton RJ, Hill JD. A randomized trial of the long-term, continued efficacy and safety of modafinil in narcolepsy. Sleep Med. 2000;1:231–43. [PubMed]
19. Czeisler CA, Walsh JK, Roth T, Hughes RJ, Wright KP, Kingsbury L, Arora S, Schwartz JR, Niebler GE, Dinges DF. U.S. Modafinil for Excessive Sleepiness Associated with Shift-Work Sleep Disorder. N Engl J Med. 2005;353:476–86. [PubMed]
20. Jasinski DR. An evaluation of the abuse potential of modafinil using methylphenidate as a reference. J Psychopharmacol. 2000;14:53–60. [PubMed]
21. Gagnon B, Low G, Schreier G. Methylphenidate hydrochloride improves cognitive function in patients with advanced cancer and hypoactive delirium: a prospective clinical study. Rev Psychiatr Neurosci. 2005;30(2):100–107. [PMC free article] [PubMed]
22. Morrow GR, Ryan JL, Kohli S, Jean-Pierre P, Carroll J, Figueroa- Moseley C, Mustian KM, Hoffman M. Supportive Care in Cancer. 2006:583–687. Abstract 11-070. [PubMed]
23. Yoshitake H. Three characteristic patterns of subjective fatigue symptoms. Ergonomics. 1978;21:231–233. [PubMed]
24. Mc Nair DM, Lorr M, Droppelman LF. Manual for the Profile of Mood States. Educational and Industrial Testing Service; San Diego: 1971.
25. Mendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, Huber SL. The rapid assessment of fatigue severity in cancer patients: Use of the Brief Fatigue Inventory. Cancer. 1999;85:1186–1196. [PubMed]
26. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The Fatigue Severity Scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch. Neurol. 1989;46:1121–1123. [PubMed]
27. Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle MT, Morrissey M, et al. Assessing symptom distress in cancer patients: the M.D. Anderson Symptom Inventory. Cancer. 2000;89:1634–46. [PubMed]
28. Booth-Jones M, Jacobsen PB, Ransom S, Soety E. Characteristics and correlates of cognitive functioning following bone marrow transplantation. Bone Marrow Transplant. 2005;36:695–702. [PubMed]
29. Baranski JV, Pigeau RA. Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo. J Sleep Res. 1997;6:84–91. [PubMed]
30. Caldwell JA, Caldwell JL, Smythe NK, Hall KK. A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study. Psychopharmacology. 2000;150:272–282. [PubMed]
31. Wesensten NJ, Belenky G, Kautz MA, Thorne DR, Reichardt RM, Balkin TJ. Maintaining alertness and performance during sleep deprivation: modafinil vs caffeine. Psychopharmacology. 2002;159:238–247. [PubMed]
32. Winningham ML, Groenwald SL, Goodman M, Frogge MH, Yarbo CH, editors. Cancer Symptom Management. Jones and Barlett; Boston: 1996. pp. 42–54.
33. Simpson P, Wesnes K, Christmas L. A computerized system for the assessment of drug-induced performance changes in young, elderly or demented populations. Br J Clin Pharmacol. 1987;27:711P–712P.
34. Wesnes KA, Ward T, Mcgintya, Petrini O. The memory enhancing effects of a gingko/biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology (Berl) 2000;152:353–61. [PubMed]
35. Wesnes KA, Simmons D, Rook M, Simpson P. A double-blind placebo controlled trial of tanakan in the treatment of idiopathic cognitive impairment in the elderly. Hum Psychopharmacol. 1987;2:159–69.
36. Wesnes KA, McKeith IG, Ferrara R, et al. Effects of rivastigmine on cognitive function in dementia with Lewy bodies: a randomized placebo-controlled international study using the cognitive drug research computerized assessmebt system. Dement Geriatr Cogn Disord. 2002;13:183–92. [PubMed]
38. O'Neill WM, Hanks GW, Simpson P, Fallon MT, Jenkins E, Wesnes KA. The cognitive and psychomotor effects of morphine in healthy subjects: A randomised controlled trial of repeated (four) oral doses of dextropropoxyphene, morphine, lorazepam and placebo. Pain. 2000;85:209–215. [PubMed]
39. Walker MP, Ayre GA, Cumming JL, Wesnes K, McKeith IG, O'Brien JT, Ballard CG. Quantifying fluctuation in Dementia with Lewy Bodies, Alzheimer's disease and vascular dementia. Neurology. 2000;54:1616–1625. [PubMed]
40. Parrott AC, Lees A, Garnham NJ, Jones M, Wesnes KA. Cognitive performance in recreational users of MDMA or `ecstasy': evidence for memory deficits. Journal of Psychopharmacology. 1998;12:79–83. [PubMed]
41. Walker LG, Wesne KA, Heys SD, Walker MB, Lolley J, Eremin O. The cognitive effects of recombinant Interleukin-2 (rIL-2) therapy: a controlled clinical trial using computerised assessments. European Journal of Cancer. 1996;32A(13):2275–2283. [PubMed]
42. Keith MS, Stanislav SW, Wesnes KA. Validity of a cognitive computerized assessment system in brain-injured patients. Brain Injury. 1998;12(12):1037–1043. [PubMed]
43. Walker MP, Ayre GA, Cummings JL, Wesnes K, McKeith IG, O'Brien JT, Ballard CG. The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale. The British Journal of Psychiatry. 2000;177:252–256. [PubMed]
44. Wesnes KA, McKeith I, Edgar C, Emre M, Lane R. Benefits of rivastigmine on attention in dementia associated with Parkinson's disease. Neurology. 2005;65:1654–6. [PubMed]
45. Kennedy DO, Scholey AB, Wesnes KA. Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng and a ginkgo/ginseng combination to healthy young adults. Physiology & Behaviour. 2002;75:1–13. [PubMed]
46. Kennedy DO, Scholey AB, Wesnes KA. Dose Dependent Changes in Cognitive Performance and Mood following Acute Administration of Ginseng to Healthy Young Volunteers. Nutritional Neuroscience. 2001;4:295–310. [PubMed]
47. Kennedy DO, Scholey AB, Wesnes KA. Differential, Dose Dependent Changes in Cognitive Performance Following Acute Administration of a Ginkgo biloba/Panax ginseng Combination to Healthy Young Volunteers. Nutritional Neuroscience. 2001;4:399–412. [PubMed]
48. Wesnes K, Faleni RA, Hefting NR, Hoogsteen G, Houben JJG, Jenkins E, Jonkman JHJ, Leonard J, Petrini O, van Lier JJ. The cognitive, subjective and physical effects of a Ginkgo biloba/Panax Ginseng combination in healthy volunteers with neurasthenic complaints. Psychopharmacology Bulletin. 1997;33(4):677–683. [PubMed]
49. Wesnes KA, Ward T, McGinty A, Petrini O. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle aged volunteers. Psychopharmacology. 2000;152:353–361. [PubMed]
50. Kennedy DO, Scholey AB, Wesnes KA. The dose-dependent cognitive effects of acute administration of ginkgo biloba to healthy young volunteers. Psychopharmacology. 2000;151:416–423. [PubMed]
51. McKeith I, Del Ser T, Spano P, Emre M, Wesnes K, Anand R, Cicin-Sain A, Ferrara R, Spiegel R. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. The Lancet. 2000 December;3562000:2031–2036. [PubMed]
52. Wesnes KA, McKeith IG, Ferrara R, Emre M, Del Ser T, Spano PF, Cicin-Sain A, Anand R, Spiegel R. Effects of rivastigmine on cognitive function in dementia with Lewy bodies: a randomised placebo-controlled international study using the Cognitive Drug Research Computerised Assessment System. Dementia. 2001;13(3):183–92. [PubMed]
53. Wesnes KA, Simpson PM, White L, Pinker S, Jertz, Murphy M, Siegfried K. Cholinesterase inhibition in the scopolamine model of dementia. Annals of the New York Academy of Sciences. 1991;640:268–27. [PubMed]
54. Kohli S, Griggs JJ, Roscoe JA, Jean-Pierre P, Bole C, Mustian KM, Zangmeister J, Smith K, Gross H, Morrow GR. Self-Reported Cognitive Impairment in Cancer Patients. Journal of Oncology Practice. 2007 March; [PMC free article] [PubMed]
55. Hurria A, Rosen C, Hudis C, et al. Cognitive function of older patients receiving adjuvant chemotherapy for breast cancer: a pilot prospective longitudinal study. J Am Geriatr Soc. 2006;54:925–931. [PubMed]
57. Lin JS, Hou Y, Jouvet M. Potential brain neuronal targets for amphetamine, methylphenidate and modafinil-induced wakefulness, evidenced by c-mos immunocytochemistry, in the cat. Proc Natl acad Sci USA. 1996;92:14128–33. [PubMed]
58. Engber TM. Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil. Neurosci lett. 1998;24:95–8. [PubMed]
59. US Modafinil in Narcolepsy Multicenter Study Group Randomized trial of modafinil as a treatment of pathological somnolence in narcolepsy. Ann Neurol. 198;43:88–97. [PubMed]
60. US modafinil in Narcolepsy Multicenter Study Group Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy. Neurology. 2000;54:1166–75. [PubMed]
61. Broughton RJ, Fleming JA, george CF, et al. Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology. 1997;49:444–51. [PubMed]
62. Mitler MM, Harsh J, Hirshkowitz M, Guilleminault C. Long-term efficacy and safety of modafinil (PROVIGIL®) for the treatment of excessive daytime sleepiness associated with narcolepsy. Sleep Med. 2000;1:231–43. [PubMed]
63. Luoma ML, Hakamies-Blomqvist L. The meaning of quality of life in patients being treated for advanced breast cancer: a qualitative study. Psychooncology. 2004 Oct;13(10):729–39. [PubMed]
64. Rugo HS, Ahles T. The impact of adjuvant therapy for breast cancer on cognitive function: current evidence and directions for research. Semin Oncol. 2003 Dec;30(6):749–62. Review. [PubMed]