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Skull Base. 2009 November; 19(6): 443–446.
Prepublished online 2009 April 9. doi:  10.1055/s-0029-1220206
PMCID: PMC2793893

Concurrent Vestibular Schwannoma and Meningioma Mimicking a Single Cerebellopontine Angle Tumor

ABSTRACT

Vestibular schwannomas account for ~;80% of cerebellopontine angle (CPA) tumors, with meningiomas being the second most common tumor of the CPA. The occurrence of both a schwannoma and a meningioma in the cerebellopontine angle is rare. After obtaining Institutional Review Board approval, we present a case of a concurrent vestibular schwannoma and meningioma in the CPA mimicking a single tumor.

Keywords: Acoustic neuroma, vestibular schwannoma, meningioma, cerebellopontine angle

CASE REPORT

A 43-year-old woman presented with an 18-month history of severe bifrontal headaches. One month before presentation, she noticed right-sided hearing loss and imbalance. She denied facial numbness or diplopia. She reported no family history of schwannomas or meningiomas. Her physical examination was normal except for a decreased right corneal reflex and decreased sensation over the right V1 distribution of the trigeminal nerve. She had no evidence of cerebellar dysfunction. Audiometry revealed an asymmetric mild sensorineural hearing loss in the right ear with a 3-frequency pure tone average (PTA) of 23 dB and 100% speech discrimination. Magnetic resonance imaging (MRI) of the brain and internal auditory canal with gadolinium contrast was obtained (Figs. 1 and and22).

Figure 1
T1 axial magnetic resonance imaging (MRI) with gadolinium demonstrates a less intensely enhancing vestibular schwannoma filling the internal auditory canal (broad arrow) with a more intensely enhancing concurrent meningioma ...
Figure 2
T1 coronal magnetic resonance imaging (MRI) with gadolinium shows the enhancing mass filling the canal and extending into the cerebellopontine angle (CPA) cistern. The two masses cannot be clearly separated from one another ...

She underwent a translabyrinthine craniotomy and was found to have two distinct tumors. The tumor involving the internal auditory canal was more typical of a schwannoma with a soft consistency and little bleeding. The tumor adjacent to the brainstem and petrous temporal bone was fibrous and vascular. The petrous temporal bone around the internal auditory canal and inferior toward the jugular foramen was grossly involved with tumor. Intraoperative frozen section analysis as well as subsequent review of permanent sections and immunohistochemical stains confirmed the suspicion that the more lateral tumor was a schwannoma and the medial tumor was a meningioma (Figs. 3 and and4).4). Subtotal resection was performed due to involvement of the jugular foramen and petrous temporal bone. She had no postoperative complications, and her postoperative facial nerve function was grade I on the House-Brackmann scale. Careful review of her family history and MRI revealed no evidence of neurofibromatosis type 2.

Figure 3
A fragment of meningioma (left) demonstrates membranous positivity for epithelial membrane antigen (EMA) by immunohistochemistry, which is consistent with meningioma, whereas a fragment of schwannoma (vestibular ...
Figure 4
The same fragment of vestibular schwannoma (right) demonstrates cytoplasmic positivity for S-100 by immunohistochemistry, which is consistent with schwannoma, whereas the fragment of meningioma (left) in the same specimen ...

DISCUSSION

Simultaneous schwannomas and meningiomas of the cerebellopontine angle are rare unless associated with neurofibromatosis type 2 (NF2). There have been very few case reports of simultaneous tumors in patients without NF2.1,2 The occurrence of simultaneous tumors should be differentiated from mixed tumors, which are schwannomas with meningeal cell proliferations. Up to 21% of schwannomas in NF2 have meningeal cell proliferations.3

The radiographic differentiation of schwannomas and meningiomas of the cerebellopontine angle have been well described.4 Meningiomas tend to be broad based, eccentric to the internal auditory canal, and often have adjacent dural enhancement (dural tails). Vestibular schwannomas usually involve and are centered on the internal auditory canal, are more rounded, and rarely have adjacent dural enhancement. Another distinguishing feature is the hyperostosis seen with ~;70% of meningiomas, which rarely occurs with vestibular schwannomas. In this case, a distinct enhancement difference could be appreciated through the mass and raised the suspicion of simultaneous tumors. In addition, the tumor entered the jugular foramen, which is uncommon in the setting of a vestibular schwannoma. Magnetic resonance imaging with gadolinium contrast is essential for accurate preoperative diagnosis and subsequent patient counseling regarding treatment, outcomes, and prognosis.

In general, the occurrence of two tumor types in the same location may be due to collision of two separate tumors, metaplasia of an existing tumor, or differentiation for the same cell line into two distinct tumors. In this case, collision of two separate tumors is most likely as indicated by the sharp contrast demarcation on the MRI and distinct histology of the specimens. If this were a mixed tumor, the likelihood of the patient having NF2 would be greater.

REFERENCES

  • Izci Y, Secer H I, Gonul E, Ongürü O. Simultaneously occurring vestibular schwannoma and meningioma in the cerebellopontine angle: case report and literature review. Clin Neuropathol. 2007;26:219–223. [PubMed]
  • Wilms G, Plets C, Goossens L, Goffin J, Vanwambeke K. The radiological differentiation of acoustic neurinoma and meningioma occurring together in the cerebellopontine angle. Neurosurgery. 1992;30:443–445. discussion 445–446. [PubMed]
  • Sobel R A. Vestibular (acoustic) schwannomas: histologic features in neurofibromatosis 2 and in unilateral cases. J Neuropathol Exp Neurol. 1993;52:106–113. [PubMed]
  • Lalwani A K, Jackler R K. Preoperative differentiation between meningioma of the cerebellopontine angle and acoustic neuroma using MRI. Otolaryngol Head Neck Surg. 1993;109:88–95. [PubMed]

Articles from Skull Base are provided here courtesy of Thieme Medical Publishers