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J Oncol Pract. 2006 November; 2(6): 317–318.
PMCID: PMC2793668

ASCO 2006 Update of the Breast Cancer Follow-Up and Management Guideline in the Adjuvant Setting


The ASCO Expert Panel presents the 2006 evidence-based clinical practice guideline for breast cancer follow-up and management in asymptomatic patients following primary, curative therapy (J Clin Oncol 24:5091-5097, 2006). The Panel performed a literature review and analysis of data published through March 2006.

Updated 2006 Recommendations

Table 1 presents a complete summary of the updated 2006 recommendations.

Table 1:
Summary of Recommendations


As guideline recommendations are based on well-defined study protocols and outcomes, many of the recommendations for the 2006 Update remained unchanged due to inapplicable study findings or no resulting survival advantages. Issues new to the guideline include fluorodeoxyglucose–positron emission tomography scanning and breast magnetic resonance imaging as follow-up strategies. However, a review of the literature revealed no evidence that use of these imaging studies would improve outcomes for asymptomatic women during routine breast cancer surveillance. The 2006 update also includes new recommendations on genetic counseling referrals for familial breast cancer syndromes consistent with recommendations from the US Preventive Services Task Force. The evidence continues to support regular history, physical examination, and mammography as the cornerstones of breast cancer follow-up and management.


The Breast Cancer Surveillance Expert Panel did not complete an independent meta-analysis of the data from available randomized clinical trials given the availability of a high-quality meta-analysis and a systematic literature review identified through the literature search. The 2006 Update literature review applied more weight to studies that tested a hypothesis directly relating testing to one of the primary outcomes in randomized design. The Expert Panel utilized the ASCO 1996 list of clinical outcomes used to justify the use of a technology to drug in the guideline development process. Outcomes of interest included disease-free and overall survival, quality of life, toxicity reduction, and cost-effectiveness.

Additional Resources

The full-text version of the guideline recommendations is available in the November 1, 2006, print edition of the JCO and also at (J Clin Oncol 24:5091-5097, 2006). In addition, a patient guide, summary slide set, patient flow sheet, and an update table are available at The patient guide is available at

The ASCO 2006 Update of Recommended Breast Cancer Surveillance Guidelines were developed and written by James L. Khatcheressian, Antonio C. Wolff, Thomas J. Smith, Eva Grunfeld, Hyman B. Muss, Victor G. Vogel III, Francine Halberg, Mark R. Somerfield, and Nancy E. Davidson, for the American Society of Clinical Oncology Breast Cancer Surveillance Expert Panel.

It is important to realize that many management questions have not been comprehensively addressed in randomized trials and guidelines cannot always account for individual variation among patients. A guideline is not intended to supplant physician judgment with respect to particular patients or special clinical situations and cannot be considered inclusive of all proper methods of care or exclusive of other treatments reasonably directed at obtaining the same results.

Accordingly, ASCO considers adherence to this guideline to be voluntary, with ultimate determination regarding its application to be made by the physician in light of each patient's individual circumstances. In addition, the guideline describes administration of therapies in clinical practice; it cannot be assumed to apply to interventions performed in the context of clinical trials, given that clinical studies are designed to test innovative and novel therapies in a disease and setting for which better therapy is needed. Because guideline development involves a review and synthesis of the latest literature, a practice guideline also serves to identify important questions for further research and those settings in which investigational therapy should be considered.

Articles from Journal of Oncology Practice are provided here courtesy of American Society of Clinical Oncology