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[Cover image of issue]

Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): Fruiting bodies of the basidiomycete Clitopilus passeckerianus, which produces a natural antibiotic called pleuromutilin. Recently, a derivative of pleuromutilin called retapamulin was approved for use in humans as a treatment for impetigo and infected wounds. However, despite its increasing importance, until now no molecular tools have been available to achieve a full understanding of this antibiotic. (See related article on page 7196.)

Appl Environ Microbiol. 2009 November; 75(22): Cover