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Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): Shiga toxin type 1 (Stx1) induces the translocation of the proapoptotic factor Bax to mitochondria in human THP-1 cells. The figure depicts immunofluorescence confocal microscopy of Stx1-treated THP-1 cells stained for Bax (green), mitochondria (red), and nuclei (blue). Monocytic (top panels) and macrophage-like (bottom panels) THP-1 cells were treated with Stx1 for 60 min (left panels) and 240 min (right panels). Translocation of Bax to mitochondria is shown by increased yellow fluorescence in merged images. Insets represent higher magnification of the boxed area. Note the extensive nuclear fragmentation of Stx1-treated monocytic cells at 240 min. (See related article on p. 5233.)

Infect Immun. 2009 December; 77(12): Cover