Untreated nestin/hRAMP1 move slower than control mice (*P < 0.01) except in the second interval in the light. There were not differences between CGRP-treated nestin/hRAMP1 and control mice. Nestin/hRAMP1 mice treated with CGRP moved faster compared with vehicle, but this only reached significance in the dark in the first (#P = 0.007) and second (#P = 0.049) intervals. CGRP-treated control mice moved faster than vehicle-treated mice in the dark in the first (‡P = 0.001) and second (‡P = 0.003) intervals and in the light in the first interval (‡P < 0.001) and second interval (P = 0.07). Control, untreated: n = 13; nestin/hRAMP1, untreated : n = 12; all other groups: n = 8. Mean ± s.e.m.