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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
J Am Coll Cardiol. Author manuscript; available in PMC 2010 September 29.
Published in final edited form as:
PMCID: PMC2782747
NIHMSID: NIHMS155371

ACCF/AHA/ACP 2009 Competence and Training Statement: A Curriculum on Prevention of Cardiovascular Disease

A Report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Competence and Training (Writing Committee to Develop a Competence and Training Statement on Prevention of Cardiovascular Disease)
American Academy of Neurology, American Association of Cardiovascular and Pulmonary Rehabilitation, American College of Preventive Medicine, American College of Sports Medicine, American Diabetes Association, American Society of Hypertension, Association of Black Cardiologists, Centers for Disease Control and Prevention, National Heart, Lung, and Blood Institute, National Lipid Association, and Preventive Cardiovascular Nurses Association
C. Noel Bairey Merz, MD, FACC, FAHA, Chair,* Mark J. Alberts, MD, FAHA, Lawrence J. Fine, MD, DrPH,††*** Gary J. Balady, MD, FACC, Vivian Fonseca, MD,‡‡ Christie M. Ballantyne, MD, FACC,* Barry A. Franklin, PhD, FAHA,§§ Kathy Berra, MSN, ANP, FAHA, FAAN,§ Patrick E. McBride, MD, MPH, FACC, FAHA,* Henry R. Black, MD,|| George A. Mensah, MD, FACC, FACP, FAHA,||||*** Roger S. Blumenthal, MD, FACC, FAHA,* Geno J. Merli, MD, FACP,# Michael H. Davidson, MD, FACC, Patrick T. O'Gara, MD, FACC, FAHA,§§ Sara B. Fazio, MD,# Paul D. Thompson, MD, FACC,¶¶ Keith C. Ferdinand, MD, FACC, FAHA,** and James A. Underberg, MD, MS, FACPM, FACP##
Jonathan L. Halperin, MD, FACC, Chair, Mark A. Creager, MD, FACC, FAHA,††† L. Kristin Newby, MD, FACC, FAHA, Gordon L. Fung, MD, PhD, FACC, FAHA, Ileana Piña, MD, FACC, FAHA, David R. Holmes, Jr., MD, FACC,‡‡‡ George P. Rodgers, MD, FACC, FAHA,‡‡‡ Geno Merli, MD, FACP, Cynthia M. Tracy, MD, FACC,‡‡‡ Ira S. Nash, MD, FACC, FACP, and Howard H. Weitz, MD, FACC, FACP

Preamble

The American College of Cardiology Foundation/American Heart Association/American College of Physicians (ACCF/AHA/ACP) Task Force on Clinical Competence was formed in 1998 to develop recommendations for attaining and maintaining the cognitive and technical skills necessary for the competent performance of a specific cardiovascular service, procedure or technology. These documents are evidence-based, and where evidence is not available, expert opinion is utilized to formulate recommendations. Indications and contraindications for specific services or procedures are not included in the scope of these documents. Recommendations are intended to guide curriculum development and assist those who judge the competence of cardiovascular health care providers entering practice for the first time and/or those in practice who undergo periodic review of their expertise or who apply for privileges at a new institution. The assessment of competence is complex and multidimensional, therefore isolated recommendations contained herein may not necessarily be sufficient or appropriate for judging overall competence. The current document addresses a curriculum for developing competence in the prevention of cardiovascular disease (CVD) and is authored by representatives of the ACCF, AHA, ACP, the American Academy of Neurology (AAN), American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR), American College of Preventive Medicine (AAPM), American College of Sports Medicine (ACSM), American Diabetes Association (ADA), American Society of Hypertension (ASH), Association of Black Cardiologists (ABC), Centers for Disease Control and Prevention (CDC), National Heart, Lung, and Blood Institute (NHLBI), National Lipid Association (NLA), Preventive Cardiovascular Nurses Association (PCNA). The recommendations contained herein recognize the broader context of clinical training and the importance of systems of care in improving patient outcomes. Trainees should be aware of and responsive to the larger context of systems-based health care, and utilize all available resources to provide optimum care. Similarly, the development of competence embodies knowledgeable incorporation of technological advances for the evaluation of health and disease based on ongoing familiarity with the emerging scientific and social literature.

The ACCF/AHA/ACP Task Force makes every effort to avoid actual or potential conflicts of interest that might arise as a result of an outside relationship or personal interest of a member of the ACCF/AHA/ACP Writing Committee. Specifically, all members of the Writing Committee are asked to provide disclosure statements of all such relationships that might be perceived as real or potential conflicts of interest relevant to the document topic. These statements are reviewed by the Writing Committee and updated as changes occur. The relationships with industry for authors and peer reviewers are published in the appendices of the document. Jonathan L. Halperin, MD, FACC Chair, ACCF/AHA/ACP Task Force on Clinical Competence and Training

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Jonathan L. Halperin, MD, FACC

Chair, ACCF/AHA/ACP Task Force on Clinical Competence and Training

1. Introduction

The mission of many organizations is the optimal care to those with or at risk for developing CVD (primary and secondary prevention). Over the past two decades, there have been dramatic increases in knowledge concerning specific risk factors in atherosclerosis, hypertension, thrombosis, and other forms of vascular dysfunction. Clinical trials have proven that strategies aimed at the appropriate detection and modification of risk factors can slow progression of atherosclerosis, diabetes mellitus, and hypertension and reduce the occurrence of clinical cardiovascular events in both primary and secondary prevention settings. More recently, it has been shown that atherosclerosis can be stabilized or even modestly reversed. Finally, a new and growing knowledge base of molecular genetics applied to the study of the cardiovascular system has potential relevance to the clinical practice of preventive cardiovascular medicine.

Despite the fact that clinical outcomes can be improved by promotion of favorable life habits and behaviors and by the proper use of drug treatment, the application of primary and secondary preventive interventions in clinical practice is not optimal. Prevention of CVD in both the primary and secondary prevention setting, while dominantly the responsibility of the primary care provider, is increasingly challenged given this ever expanding new knowledge as well as the ongoing problems related to adherence to recommendations. New knowledge in the area of pre-clinical disease detection has presented increasingly challenging scenarios to primary care healthcare providers relative to the decisions regarding the need for further risk stratification and aggressive medical regimens. Furthermore, increasingly complex patients are surviving with CVD, many of whom can benefit from advanced knowledge and expertise with regard to risk factor management and rehabilitation that is beyond traditional general primary and cardiology practitioner's scope of practice.

The prevention of cardiovascular morbidity and mortality is a shared responsibility among all health professionals involved in the care of people at risk of developing cardiovascular disease. This document is directed at those individuals seeking expertise at a leadership level in this field, and includes opportunities for formal training and alternative routes to competence and maintenance of competence in prevention of cardiovascular disease (Table 2), and educational resources for acquisition and maintenance of competence in the prevention of cardiovascular disease (Table 3). To address the expanding fund of knowledge in the area and to ensure that an adequately trained force of preventive cardiovascular leaders will be available to primary care providers, as well as provide a pool of providers with expertise in running rehabilitation and other programs designed to address the ongoing issue of adherence, the formulation of clinical competency criteria for the cardiovascular preventive specialist is needed. These competency criteria are expected to address issues of expert clinical and scientific leadership, specialty patient care and consultation, and directorship of primary and secondary preventive cardiac programs. Of note and similar to other subspecialty areas of medicine, cardiovascular preventive specialists will have varying areas of expertise and will not necessarily achieve all the outlined areas of competencies. These clinical competency criteria in the area of specialty treatment and prevention of CVD are needed given the current setting of a rapidly growing field of knowledge ranging from molecular and cellular mechanisms to clinical outcomes in order to translate into improved patient care.

Table 2
Opportunities for Formal Training and Alternative Routes to Competence and Maintenance of Competence in Prevention of Cardiovascular Disease
Table 3
Educational Resources for Acquisition and Maintenance of Competence in the Prevention of Cardiovascular Disease
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C. Noel Bairey Merz, MD, FACC, FAHA

Chair, ACCF/AHA/ACP Clinical Competence Statement on Prevention of CVD

2. Cardiovascular and Vascular Biology

2.1. Justification

Recent advances in cardiac and vascular biology and related molecular and cellular mechanisms provide a sound scientific foundation for the practice of preventive cardiovascular medicine. A basic knowledge of the structure and function of the arterial wall, its interactions with components of the circulating blood, and key pathologic processes such as oxidation, inflammation, thrombosis, and remodeling is important to the application of strategies for the detection, evaluation, and prevention of atherosclerotic CVD (1, 2). Similarly, a basic understanding of myocardial cellular and molecular processes is essential for effective application of therapies that address myocardial salvage, regeneration, and remodeling.

2.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. The process of atherosclerosis that begins in youth, initially as a fatty streak containing mainly lipid-rich macrophages in the arterial intima (3), and the role of various blood lipoproteins in this process and the factors that promote the initiation and progression of the fatty streak to arterial plaque (including endothelial activation and dysfunction; smooth muscle cell migration and proliferation; collagen production; and arterial remodeling).
  2. Disorders of lipid metabolism and major atherogenic risk factors, and the pathophysiological significance of the biological composition of the arterial plaque and its fibrous cap (4, 5).
  3. Vulnerable plaque and the crucial role of inflammation, plaque fissuring, erosion, and rupture in the genesis of acute coronary syndromes, should be emphasized. The concepts of plaque remodeling and progression should also be understood, as well as an appreciation of the systemic nature of atherosclerosis.
  4. Systemic (endocrine) and local (autocrine/paracrine) neurohormonal derangements that lead to an impaired vasoregulatory and fibrinolytic balance, including the biological, social, and environmental determinants of these derangements as well as the pharmacologic and therapeutic lifestyle changes established for their control.
  5. Mechanisms of atherosclerosis-specific targeted interventions with the use of combination medications that can be used to slow progression and reverse the process (6).
  6. Vascular and hemodynamic benefits of smoking cessation, increased physical activity, and a diet low in saturated fats and rich in fruits, vegetables, fiber, and whole grains, particularly promoted at an early age.

3. Clinial Epidemiology and Biostatistics

3.1. Justification

Clinical epidemiology is the study of the magnitude, distribution, and trends in the factors that affect health, disease, and their determinants in populations (7). Within the context of preventive cardiology, clinical epidemiology provides crucial information in the enumeration of CVD events, rates, trends and outcomes in defined populations and their sub-groups. It also permits the identification of populations at different levels of risk for CVD events and the existence of health disparities (8). The surveillance components of clinical epidemiology provide clues to new and emerging CVD threats and permit assessment of the effectiveness of interventions.

Recent emphasis on quality, economic endpoints, and modeling in epidemiologic studies provide an opportunity for epidemiology to inform clinical practice on the cost-effectiveness and health impact of alternative preventive strategies (912). In addition, clinical epidemiology serves an important role in informing practitioners about the use of evidence from clinical trials and the strength and generalizability of that evidence. In this endeavor, the related field of biostatistics provides important principles for appropriate design of clinical trials, interpretation of trial results, and the effective use of screening, diagnostic, and prognostic tools in the practice of preventive cardiology (13).

3.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Terms used to describe the central tendency of population distributions (e.g.: mean, median, and mode) and the terms used to describe the magnitude of dispersion around these measures (e.g.: standard deviation, standard error, percentiles) (713). They should also be familiar with terms that describe the frequency and burden of CVD as well as the importance of age-adjustment.
  2. Terms used to characterize screening and diagnostic tests including sensitivity, specificity, accuracy, and predictive values (positive and negative) (13, 14).
  3. Experimental study designs (randomized, non-randomized, and non-inferiority clinical trials) and non-experimental designs (cohort, case-control, nested case-control, cross-sectional studies), as well as the principle of hypothesis testing that underlies these studies, and the number needed to treat and the number needed to harm (7).
  4. Common analyses encountered in the medical literature such as the t-test, chi-square test, multiple regression, Kaplan-Meir survival analysis, and the Cox proportional hazard analysis is necessary (7), including the types of errors that can be committed when inferences are made about data in studies.
  5. Traditional risk factors (1517), and non-traditional risk factors, such as calculation of non-high-density lipoprotein cholesterol (non-HDL-C) in persons with triglyceride levels above 200 mg/dl.
  6. Inflammatory biomarkers, including high sensitivity C reactive protein, serum amyloid A, interleukin-6, lipoprotein associated phospholipase A2, monocyte chemoattractant protein-1, soluble CD40 ligand, myeloperoxidase and their possible utility in risk assessment (18, 19).
  7. The concepts of relative and absolute risk; short-term, long-term, and lifetime risk; and the population burden of CVD attributable to specific risk factors, including the Framingham Risk Assessment score in clinical practice and knowledge of its limitations (20).
  8. Cost-benefit analyses of CVD interventions.

4. Cardiovascular Pharmacology (Complex Multi-Pharmacologic Understanding)

4.1. Justification

Knowledge of cardiovascular pharmacology, and the basic principles of pharmacokinetics, pharmacodynamics and pharmacogenomics is critical to the targeted application of drug therapy for individual patients. A basic knowledge of drug interactions, anticipated side effects, and dosing regimens in a heterogeneous mix of complex patients is necessary to integrate new research and new approaches for CVD prevention and treatment. The challenges posed by age, gender, reproductive hormones and medical co-morbidities, including the co-existence of disorders known to contribute to cardiac and vascular endothelial dysfunction, must be recognized. Interactions between medication and nutrition (e.g. grapefruit), over the counter supplements (e.g. antioxidant vitamins), nutriceuticals (e.g. stanol/sterol esters), and dietary alcohol intake are increasingly reported and of practical relevance. Knowledge that pharmacologic therapies may have differing impact based on underlying existence of disease and endogenous hormone status, including hormonal therapies, is important. A basic understanding of pharmacology will also be important as new therapies myocardial salvage, regeneration and remodeling become available.

4.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Pharmacological approaches to lipids, hypertension, thrombosis, diabetes and insulin resistance, cigarette smoking cessation, and obesity (17). The important role of statins and other lipid-lowering medications, anti-platelet therapies, renin-angiotensin-aldosterone system agents, and antihypertensive medications should be considered (6).
  2. Use of multiple drug combinations (co-existent conditions and risk factor clustering) (21) and drug-drug interactions (22), including the ever-increasing complexity of pharmacological regimens and potential and realization of drug-drug interactions.
  3. Preventive cardiovascular strategies for comorbidities such as renal disease, autoimmune inflammatory disorders, diabetes mellitus, and cancer which raise the risk for CVD due to the comorbidity itself as well as the treatment regimens used to treat these comorbidities.
  4. Pharmacologic dosing adjustment in consideration of issues of aging (23), gender (24), ethnicity, and comorbidities, for example, renal disease and liver disease, and ethnicity. Aggressive preventive cardiovascular regimens are optimally tolerated when body weight and renal function adjusted, including the elderly, women and smaller sized men. Knowledge of ethnic groups that have higher rates of toxicity to certain medications is also important.
  5. Pharmacological interactions with over-the-counter supplements, nutriceuticals (soluble fiber, psyllium seed, stanol/sterol esters), and common dietary ingredients, such as grapefruit, which can interact with many common medications including most statins, increasing blood levels of the medication when taken concurrently (25). A majority of patients are taking over the counter supplements that may interact with their medication, such as the antioxidant vitamins that adversely interact to reduce the antiatherosclerotic niacin benefit.
  6. Pharmacogenomics, including the prospective role for patient testing for genetic polymorphisms that raise/lower the likelihood of adverse pharmacological side effects, or lack of metabolism/efficacy with a particular class of medications.

5. Genetics and CVD in Individuals and Families

5.1. Justification

Genes and gene-environment interactions play important roles in the causation, pathogenesis, and prognosis of CVD (26, 27). Thus, knowledge of the spectrum of inherited susceptibilities to CVD, and elucidation of the patterns of inheritance for specific genetic abnormalities may provide improvements in early detection, risk stratification, and prevention of CVD in individual patients and their family members (2629). Additionally, advances in pharmacogenomics provide an opportunity for improving disease treatment and response (30, 31).

A wide spectrum of CVD with inherited genetic susceptibilities is now known and the advances made over the last 25 years in understanding the genetic basis of these disorders provide a rationale for ensuring competence in genetics for experts in the prevention of cardiovascular diseases (3234) The limitations of current genetic information in patient care, and the gaps between knowledge of an apparently inherited susceptibility and the availability of, or access to, corresponding effective treatments must be explicitly acknowledged (35). Finally, the benefits, risks, and costs associated with knowledge of a patient's genetic susceptibility to CVD and the ethical implications of referral for genetic testing and counseling must be recognized (36, 37).

5.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Basic skills in eliciting a comprehensive family history during the patient encounter and familiarity with clinical tools and/or questionnaires for collecting genetic information.
  2. Differences between genotype and phenotype and the concepts of dominance, recessiveness, X-linked inheritance, genetic heterogeneity, and penetrance.
  3. Basic principles of clinical genetics including the types of family studies, linkage analyses, genetic association studies, and familiarity with recent advances in genome-wide association.
  4. Chromosomal deletions, duplications, and rearrangements as a cause of clinical syndromes associated with genetic disorders.
  5. Mendelian disorders and syndromes associated with congenital heart disease (e.g., DiGeorge, Noonan, and Williams syndromes) and those involving connective tissue (e.g., Marfan syndrome, Ehlers-Danlos syndrome).
  6. Genetic basis of specific cardiovascular disorders such as cardiomyopathies, arrhythmias, and lipoprotein disorders and their potential role in diagnostic evaluation and treatment.
  7. Teratogens including warfarin, hydantoin, retinoic acid, valproic acid, rubella, and alcohol.
  8. The indications for, as well as benefits, risks, and ethical implications of referral for genetic testing and counseling, and the limitations of available testing kits.

6. Behavioral and Psychosocial Programs (Financial and Socioeconomic Factors)

6.1. Justification

Psychosocial factors add a significant dimension to CVD development and outcomes (3843). Psychosocial factors influence the pathophysiology of disease, access to health care services, and adherence to treatment (44, 45). The best treatments are of no use to a patient if they cannot access the health care system, have inadequate services, or obtain health care too late to change the outcome (4650).

Prospective cohort studies provide evidence for a role for depression, stress, psychosocial work characteristics, social isolation and support, and possibly hostility, as factors in the etiology of CVD and prognosis after CVD diagnosis (3843). Over 30% of all patients with diagnosed cardiovascular or cerebrovascular disease have either clinical depression, anxiety, or other psychologically adverse conditions (40, 41). Depression is common overall, and risk is increased following a CVD event (39, 41, 43). Depression is a risk factor for coronary heart disease (CHD), recurrent CHD events, and heart failure (HF), and is associated with poor outcomes in CVD, post-coronary bypass, and HF. Socioeconomic factors, such as education, occupation, income and insurance status have a significant impact on risk factor development and CVD and mortality (38, 5155).

All physicians and other health care providers should be able to diagnose anxiety and depression, and this should be routine after a CVD event or stroke (41). While psychological and medical interventions to treat depression and anxiety have not been shown to reduce future cardiac events to date, further research is underway to determine if outcomes after CVD events are benefited with treatment (41, 46, 47, 50, 56). Cardiac rehabilitation programs which incorporate psychosocial screening and intervention can improve treatment outcomes, the quality of life, and adherence of patients with psychological disorders (49, 57).

6.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Psychosocial factors in the development of CVD and on CVD outcomes, particularly as barriers to treatment implementation.
  2. The diagnosis of anxiety and depression disorders, recognize suicidality and the appropriate use of referrals.
  3. Use of pharmacotherapies in the treatment of depression including patient selection, side effects, monitoring for efficacy, and impact on risk factors.
  4. Recognition of safe treatments for anxiety and depression in patients with CVD.
  5. Recognition when referral for psychiatric or psychologic care is needed and appropriate.
  6. Cardiac rehabilitation for the assessment and management of psychosocial conditions to CVD.
  7. The role of health care systems and financing on psychosocial risks and outcomes for CVD, including the role of social workers and case managers in identifying and facilitating social services.

7. Advanced Risk Assessment (Renal, Inflammatory Diseases)

7.1. Justification

The assessment of both traditional and non-traditional risk factors underlies the primary and secondary prevention of CVD. Novel biomarkers are emerging as prognostic tools for CVD risk assessment. Persons with chronic kidney disease are considered to be a CHD risk equivalent by some guidelines (58, 59). The doses of many cardiovascular medications need to be adjusted in persons with chronic kidney disease, especially as glomerular filtration rate (GFR) declines and chronic kidney disease worsens.

Adults with inflammatory diseases such as lupus, psoriasis, or rheumatoid arthritis seem to be prone to accelerated atherothrombotic vascular disease (60, 61). Health care providers need to be more aggressive in trying to motivate patients with chronic kidney disease or inflammatory disorders to optimize their lifestyle habits and to achieve optimal levels of blood pressure and lipids. A number of ongoing studies are trying to assess the role of chronically high levels of inflammation in the development of CVD. Persons with lupus may also need to be screened for a prothrombotic state.

Recent studies have also shown that acute myocardial infarction rates and cardiovascular risk factors are increased in person with human immunodeficiency virus (HIV) infection as compared to non-HIV patients (62, 63). Certain classes of antiretroviral drugs, especially protease inhibitors, appear to promote dyslipidemia and may independently increase risk via inflammatory pathways (64). Strategies to reduce risk for atherosclerotic vascular disease should be incorporated into the standard care of HIV infection.

There is considerable research going on that is dealing with the prognostic role of biomarkers in persons with renal, inflammatory, or chronic infectious disease in both the primary and secondary prevention settings. In future years we will have a better understanding of when measurement of biomarkers such as C-reactive protein, B-natriuretic peptide, and urinary microalbumin should change standard clinical management and the intensity of risk factor modification (6567).

7.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Measurement of urinary albumin creatinine ratio in changing pharmacologic management.
  2. Inquiry regarding erectile difficulties on at least a yearly basis as a marker for early atherosclerotic vascular disease and generalized endothelial dysfunction.
  3. Measurement of systolic blood pressures in each brachial artery and one of the pedal arteries in each foot can be done to calculate an ankle-brachial index (ABI), and the therapeutic implications for diagnosis of peripheral vascular disease, a CHD risk equivalent.
  4. Individuals with certain infectious diseases, chronic inflammatory conditions and other collagen vascular diseases are often at increased risk for atherosclerotic vascular disease and need to undergo comprehensive risk factor modification (62).
  5. Patients with a history of chest wall irradiation are prone to premature atherosclerotic disease and aggressive management of all risk factors is appropriate.

8. Subclinical Atherosclerosis Assessment (Imaging and Nonimaging)

8.1. Justification

The pre-clinical detection of atherosclerosis is an area of growing interest. The concept is to detect lesions in the cerebral, coronary, or peripheral vasculature before symptoms of end-organ ischemia occur (transient ischemic attack/stroke, angina/myocardial infarction (MI), claudication/limb ischemia), or before rupture and bleeding (aortic aneurysm) (6870). Two recent studies from the MESA (Multi-Ethnic Study of Atherosclerosis) trial have clearly documented the prognostic power of elevated coronary calcium scores (71, 72). Such patients could be targeted for intensive risk factor control, other medical interventions, and endovascular or surgical treatments if indicated.

While the concept of preclinical detection is appealing for several reasons, controversy exists about the usefulness and efficacy of some screening programs and paradigms. The preventive cardiovascular specialist should have the knowledge base and skills to 1) advise patients about the usefulness of such screening including costs, 2) interpret the results of a screening test in terms of formulating a care plan, and 3) provide guidance about the need for subsequent testing and therapy.

Some screening approaches entail financial as well as potential medical risks, particularly if a positive test leads to further investigations and in some cases medical, surgical, or endovascular interventions. Thus it is important to have some guidance about what competencies are needed in these areas.

8.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. General epidemiology and risk factors for asymptomatic disease in various vascular beds. Knowledge of these factors and associations will be helpful to the clinician in determining which patients are at higher versus lower risk to have asymptomatic disease in various vascular beds.
  2. While controversial as to efficacy, the potential screening modalities for asymptomatic disease in the various vascular beds (see Table 1). (69, 7386).
    Table 1
    Testing Modalities
  3. Technical limitations, overall sensitivity, specificity, accuracy, and risks of various screening tests (73, 78, 81, 86, 87). Radiation exposure from coronary CTA may increase the risk of breast cancer, but the amount of ionizing radiation associated with the test is considerably less than that associated with a stress radionuclide exam (88). Knowledge of these factors will be important for the clinician to weigh the results and risks of such screening tests and determine the need for further testing depending on the overall clinical scenario.
  4. The need for further testing in patients with evidence of asymptomatic disease (see Table 1). This would include the clinical indications for further testing, the methods used for subsequent testing, and their limitations (false positive, false negatives, overall accuracy) (70, 75, 86).
  5. How to treat patients with the presence of asymptomatic disease in various vascular beds, and the risks and benefits of these various treatments and interventions, and patient education and knowledge of sources for such educational information (i.e. Websites, non-profit organizations).
  6. How to order and/or interpret the above screening tests, understand the test results, explain their meaning to the patient, and plan further testing and treatment, perhaps in consultation with other medical specialists in related areas of vascular medicine.

9. Adherence and Disease Outcome Interdisciplinary Programs

9.1. Justification

Adherence is a measure of how consistently a patient follows the specific requirements of an intervention. Knowledge about how to achieve a superior level of adherence is crucial. While the true rate of patient adherence is difficult to measure without using sophisticated tools that in themselves may influence patient behaviors, research generally indicates that long term adherence to behavioral and medical intervention may be as low as 50% (89). Nevertheless, in some settings and in some patients much higher rates of adherence occur suggesting that low rates of adherence result from specific causal factors such as the cost of medications, depression, or low health literacy, and that adherence is amenable to change. Some personal factors such as personality traits do not consistently influence adherence while others such as self efficacy do. Societal, health care system, and provider factors likely influence adherence rates (9092). Successful prevention often requires life long actions by the patient and therefore a high level of long-term adherence is very important to effective prevention (93).

Disease outcome or management programs usually consist of at least two program elements: a patient monitoring component and a system to respond proactively to changes in the patient's symptoms or physical status. Effective disease management programs should reduce or delay the adverse consequences of chronic CVD events such as preventing or reducing the number HF hospitalizations in patients with HF and reduce the episodic nature of health care based on the treatment of acute episodes (94). The long term efficacy of most disease programs is uncertain. Since many patients have several chronic illnesses or complex prevention problems, the concepts underlying disease outcome interdisciplinary programs may in the future be applied to a wider set of prevention problems. Both adherence and disease outcome management programs are based on the integration of biologically derived scientific concepts with behavioral and social science concepts.

9.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. How to measure adherence through a variety of approaches such as history, and medication reconciliation.
  2. How to determine the causal factors underlying non-adherence, including the important patient factors such as healthy literacy, depression, co-morbid conditions, trust in the health care provider, adverse effects, and economic factors.
  3. Patient level interventions to improve adherence such as reducing the cost of medications, treating depression, and use of aids like weekly pill boxes.
  4. Important provider factors such as interest in adherence, and skill in identifying barriers to adherence, combined with understanding important health care system and societal factors such as ease of maintaining the intervention or medication, cost, systematic reminders, and number and frequency of patient contacts.
  5. Components of a successful disease outcome program such as prompt evaluation and detection of new symptoms and adjustment of medications in response to changes in symptoms; frequency and duration of patient interactions with the disease management program; and mode of collecting information on patient status including self reports and automated devices.
  6. Disease management programs, the role of feedback to the patient and provider beyond adjustment of therapeutic regimen and the expected roles of the patient and their family, the provider and other health personnel in a disease management program.
  7. Common Theoretical Models for adherence and disease management such as: Stages of Change (95); Wagner's Chronic Care Model (96); Self Efficacy (97).
  8. Motivational interviewing and other patient empowerment techniques.

10. Nutrition Management

10.1. Justification

Many of the conditions and disease states that affect atherosclerotic risk can be prevented or at least modified by dietary interventions. These conditions and diseases include obesity and excess body weight, hypertension, lipid abnormalities, and diabetes. Even when conditions such as hypertension and hyperlipidemia are established and require pharmacologic therapy, dietary manipulations can reduce the dosage of medication required to achieve therapeutic goals. Similarly some nutritional supplements (e.g. red rice yeast (98) and omega 3 fatty acids (99)) contain pharmacologically active substances that can be used therapeutically in selected patients. In contrast, some dietary and nutritional supplements may contain substances such as sympathomimetics that increase cardiac arrhythmias. Consequently, healthcare providers practicing preventive cardiology must be required to have an understanding of nutrition and the principles of nutrition so that they are able to provide expert advice to patients and to reinforce expert advice given by nutritional professionals. In addition, credibility as a preventive specialist with patients is enhanced when the preventive cardiologist is conversant in the basics of diets and nutritional therapy.

10.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Obesity, its role in producing insulin resistance and the metabolic syndrome, the healthcare provider's role in helping patients maintain body weight, the basic classifications of body weight, the contribution of overweight to hypertension and hyperlipidemia, the basic concepts of caloric balance, the caloric content of the major food groups, the role of exercise in helping to maintain body weight, the action of the available prescription weight loss drugs and their possible cardiovascular side effects, including that recommendations may differ according to age (pediatric versus adult versus very elderly).
  2. Surgical approaches to morbid obesity and the possible medical complications of this surgery.
  3. Composition of diets used to assist in blood pressure control reduced sodium, calorie reduction for weight loss, moderation of alcohol consumption, increased potassium intake, and consumption of an overall healthy diet (100).
  4. Composition of therapeutic diets used to manage hypercholesterolemia and hypertriglyceridemia and especially the effect of saturated fats, transfatty acids, and low dietary fat and cholesterol on serum lipids (101). In addition, the preventive cardiology specialist should be conversant in discussing the origin of dietary fats with regard to therapeutic potential (101, 102).
  5. Composition of diets used in patients with impaired glucose tolerance and diabetes (103).
  6. Use of over the counter and nonprescription agents in lipid management including the risk and benefits of plant stanols and sterols (104), fish oils (99), dietary fiber (99, 105).
  7. Potential cardiac dangers of too rapid weight loss (106).
  8. The limited role of dietary antioxidants in preventing atherosclerotic disease (98, 107).
  9. The role of alcohol intake in causing and preventing cardiac disease (108, 109).

11. Lipid Management (Management of Dyslipidemia)

11.1. Justification

The management of dyslipidemia has emerged as a key therapeutic strategy to reduce both primary and secondary cardiovascular events. Despite a plethora of large outcome trials (110112) supporting the evidence for lipid-altering treatments to improve outcomes and national guidelines that have established specific goals of treatment, there remains a significant treatment gap in the achievement of low-density lipoprotein cholesterol (LDL-C), non-HDL-C, and HDL-C targets (113, 114). The National Cholesterol Education Program ATP III (NCEP ATP III) Guidelines (115) updated in 2004 (116) mandate an LDL-C goal for high-risk patients of less than 100 milligrams per deciliter with an optional goal of less than 70 milligrams per deciliter for patients with CVD plus diabetes or other multiple risk factors. The AHA Secondary Prevention Guidelines also advocate an LDL-C goal and non-HDL-C goal of less than 70 milligrams per deciliter and less than 100 milligrams per deciliter, respectively (17). Yet, recent surveys demonstrate that less than one-third of patients with CVD with additional risk factors are achieving these recommended targets (113). In addition, patients with low HDL-C and/or elevated triglycerides remain at elevated residual risk even at recommended LDL-C goals (117119).

11.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Basic lipid metabolism including both exogenous and endogenous lipoprotein synthesis.
  2. Synthetic process in which chylomicrons, very low-density lipoprotein, LDL-C, and HDL-C are developed and the genetic disorders which are associated with dyslipidemia.
  3. The diagnosis of familial hypercholesterolemia, familial combined hyperlipidemia, and familial hypoalphalipoproteinemia, which are associated with significantly increased risk of premature atherosclerosis.
  4. Familiarity with NCEP guidelines, including the recent updates that recommend optional LDL-C targets for very high-risk patients.
  5. Matching the intensity of treatment to the risk of the patient. This is the cornerstone of national guidelines and the preventive cardiovascular specialist, should be familiar with the clinical trials that provided the evidence for more aggressive LDL-C reduction.
  6. Ability to instruct a patient on appropriate therapeutic lifestyle changes that includes an understanding of a low saturated fat and dietary cholesterol food management program and, if necessary, the incorporation of viscous soluble fiber and plant stanols/sterols to further lower LDL-C levels, and the importance of reducing trans fats, cholesterol and simple carbohydrates in patients with high triglycerides and abdominal obesity.
  7. Mechanism of action of statins and the expected efficacy of each dose of statin and, therefore, the ability to achieve the NCEP ATP III goals, plus the mechanism of action of niacin, ezetimibe, fibrates, bile acid sequestrants, and omega-3 fatty acids and their expected effects on LDL-C, HDL-C, and triglycerides and risks and benefits of combination therapy.
  8. Potential side effects of treatment to counsel patients and avoidance of drug interactions is imperative to improve the safety and compliance of long-term treatment.

12. Thrombosis Management

12.1. Justification

Atherothrombosis is a progressive process that includes atherosclerotic plaque formation, disruption, and thrombosis. These processes constitute the pathophysiology that underlies acute coronary syndrome, ischemic stroke or transient ischemic attack, and PAD. United States prevalence data lists 7.2 million people affected by MI, 6.5 million with angina pectoris, 5.5 million with stroke (120), with 8 to 12 million people affected by PAD (121). The Adult Treatment Panel III of the National Cholesterol Education program considered PAD to be a CHD risk equivalent (115). The recently published REACH registry (REduction of Atherothrombosis for Continued Health) showed that among patients with symptomatic atherothrombosis, 16% had symptomatic polyvascular disease (122). Approximately 56% of stroke patients 60 years and older have coexisting CAD and evidence suggests the 20% to 40% of patients with ischemic stroke or transient ischemic attack concurrently have silent CAD (123, 124).

12.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Core set of risk factors which include hypertension, diabetes, hypercholesterolemia, tobacco use, and obesity contribute to the bulk of the risk for atherothrombosis (122), and novel parameters such as lipoprotein(a), apolipoprotein A–I, and apolipoprotein B-100, fibrinogen, homocysteine, and high sensitivity (hs) C-reactive protein (17, 125).
  2. Management of unstable angina and non-ST segment elevation MI is extensive with multiple antithrombotic therapy combinations, and implement systems for antithrombotic therapy recommended in the American College of Cardiology/American Heart Association guidelines for unstable angina and non-ST segment MI (126).
  3. Antithrombotic therapy options for preventing recurrent stroke and other cardiovascular events in patients with non-cardioembolic ischemic stroke (127).
  4. Risk factor identification and early assessment of PAD (122, 125, 128), and use of antithrombotic agents to prevent atherothrombotic events in this patient population. (129132), including their indications and contraindications, mechanism of action, efficacy, side-effects, drug interactions, and costs (133).

13. Hypertension Management

13.1. Justification

Hypertension is a major contributor to the global disease burden and is one of the leading preventable causes of premature death worldwide (134). In the United States, a disproportionate burden of hypertension and its associated complications, including CHD, HF, stroke, and end-stage renal disease and CVD mortality, affect African Americans (also referred to as US Blacks) (135). Preventive cardiovascular specialists should have knowledge of hypertension and mechanisms of elevated blood pressure, and understanding of the therapeutic lifestyle changes and pharmacologic interventions that are crucial for controlling hypertension in clinical practice. A basic knowledge of the potential mechanisms of elevated blood pressure and associated risk factors is necessary to understand the ongoing research into new approaches for prevention, identification and therapy. A basic understanding of the use of therapeutic lifestyle changes and appropriate drug therapies for patients with compelling indications is necessary to reduce cardiovascular morbidity and mortality.

13.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Major risk factors for hypertension as described by the Joint National Committee 7 (136), and the impact of hypertension on CVD morbidity and mortality specifically related to MI, HF, stroke, and renal failure, and the diagnostic categories and treatment goals.
  2. Therapeutic lifestyle and pharmacologic interventions on hypertension and CVD including weight reduction, adopting DASH eating plan, sodium reduction, physical activity, moderation of alcohol consumption and medication regimens.
  3. Indications for and interpretation of ambulatory blood pressure and home blood pressure monitoring.
  4. Definition and approach to white coat hypertension and masked hypertension.
  5. Evaluation and treatment of identifiable causes of hypertension (secondary hypertension), including chronic kidney disease, coarctation of the aorta, glucocorticoid excess states, pheochromocytoma, primary aldosteronism, renovascular hypertension, sleep apnea, thyroid/parathyroid disease, and drug-induced or drug related.
  6. Definition, differential diagnosis and treatment of resistant hypertension.
  7. The findings of clinical trials in hypertension with evidence supporting compelling indications and contraindications for antihypertensive drug classes.

14. Smoking Cessation

14.1. Justification

Smoking remains the most important risk factor for CVD in the world (137, 138). It is estimated that 40% of all heart disease is related to smoking (139, 140). The biochemical and physiological consequences of smoking on CVD are well defined (139, 141, 142). Compelling evidence exists demonstrating that smoking cessation is associated with significant reversal of risk for CAD, stroke, and cancer related deaths (137). In addition, there are multiple societal consequences from cigarette smoking including enormous economic costs. In the United States alone, it is estimated that smoking costs $167 billion each year (137). Since 1965, smoking in the United States has declined by 47% among people over the age of 18. However, it is estimated that over 23% of adult men and 19% of adult women continue to smoke and this number is rising in the young (137). In addition, exposure to second hand smoke places significantly more persons at risk for heart disease and stroke (143, 144).

Clinical competency in smoking cessation treatment is critical for those whose expertise encompasses primary and secondary prevention of CVD and stroke. Clinical competency includes skills in patient education, counseling, and behavioral change, and knowledge of important pharmacotherapies, including risks and benefits. Clinical competency relies on the identification of smoking status in all patients, prompt and definitive advice to quit, and the implementation of smoking cessation counseling and pharmacotherapies. Systematic follow-up of all smokers at subsequent visits and the involvement of health care professionals with smoking cessation expertise improves life time smoking cessation.

14.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Short and long-term pathophysiological consequences related to tobacco use which include pulmonary and cardiovascular diseases (141, 142, 145152).
  2. Pathophysiology of smoking addition and be knowledgeable of the methods of assessing the physiologic levels of nicotine addiction. (e.g. Fagerstrom Questionaire) (152).
  3. Use of behavioral skills that facilitate smoking cessation, including: interpersonal communication skills, behavioral change techniques such as self monitoring and self care, stress management counseling, patient contracting and goal setting, self efficacy, motivational interviewing and relapse prevention (145, 149, 152154).
  4. Use of the 5 As: (Ask, Advise, Assess, Assist, and Arrange) treatment intervention during office visits. Each visit should include preparation, relapse prevention and counseling (145, 149, 152).
  5. Use of pharmacologic therapies to support smoking cessation based on age, pregnancy status, medical history, and comorbidities of the patient (142, 145, 146, 151, 155159).

15. Obesity Management (Behavioral Programs)

15.1. Justification

Obesity is a disease that is reaching epidemic proportions, not only in the United States, but elsewhere throughout the world. At the present time, greater than 60% of the United States adult population is classified as either overweight or obese (160, 161). In addition, childhood obesity is growing in an alarming fashion. Overweight and obesity are particularly prevalent in certain minority groups and in individuals of lower socio-economic status. Overweight is defined as a body mass index of 25 to 29.9 kg/m2, and obesity as a body mass index greater than 30 kg/m2 (162). Higher body weight is associated with an increased risk of hypertension, hyperlipidemia, stroke, CAD, insulin resistance and type 2 diabetes mellitus. Moderate weight loss has been shown to decrease the severity of these comorbidities, and data from observational studies suggests a concomitant decrease in mortality (163, 164).

Overweight and obesity are felt to result from an imbalance between energy intake and expenditure. Less than 20% of American adults regularly engage in moderate physical activity. The AHA identified an “epidemiological triad” in Prevention Conference VII (November 2004), which includes host factors (genetic make up, age/gender, attitudes and behavior), vectors for increased energy consumption or decreased energy expenditure (i.e. automobile travel instead of walking or biking, large portion sizes, high fat and high calorie foods), and environmental factors (i.e. cost of goods, government policy, as well as socio-cultural forces). They suggest that all components need to be addressed in order for successful prevention to occur (165).

A variety of behavioral options exist to manage overweight and obesity effectively, which include dietary therapy, physical activity, and behavioral techniques. To be successful in achieving long-term weight maintenance, however, these methods have to be individually applied to each patient in the context of regular and consistent medical supervision. Reduction of initial body weight by only 5% to 10% has been shown to result in significant cardiovascular risk factor reduction (166), as well as a variety of other health benefits. Presently, training on overweight/obesity in specialty and subspecialty medical education is woefully inadequate.

15.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Assessment of the overweight/obese patient involves calculation of body fatness which can be estimated by body mass index, waist circumference, overall cardiovascular risk status, as well as the patient's motivation to lose weight, including the methods for measurement of these. Importance of documenting previous history of weight loss attempts, social supports available, the patient's attitude towards and ability to perform physical activity, as well as financial considerations that may impact his or her attempts at weight loss.
  2. Initial goal of weight loss therapy is to reduce body weight by 7% to 10% over a 6 month period of time, after which, the rate typically declines. Knowledge that reassessment should occur to determine if further weight loss is desirable, and that efforts at maintaining weight loss must be put into place.
  3. Caloric content and caloric balance of the major food groups, the physiologic and pathologic effects of excess body weight, and the principles of weight loss via reduced caloric intake and increased caloric expenditure.
  4. Combination of individually planned dietary, exercise and behavioral techniques, and when to use a low calorie diet versus a very-low calorie dietary strategy (167), as well as an understanding of exercise physiology, and guidelines for activity prescription, including aerobic exercise and strength training (168).
  5. Behavioral therapy should be employed with the use of other health care professionals to include stress management/problem solving techniques, enhancing social support, cognitive restructuring and promoting the ability to self-monitor, as well as setting realistic goals.
  6. Maintenance of weight loss is often more difficult than the initial loss, thus the practitioner must be skilled at understanding the utility of a multi-faceted program that consists of ongoing dietary management, physical activity, as well as behavioral management.
  7. Challenges of treating special populations, such as children/adolescents, the elderly, and smokers.
  8. Guidelines for pursing pharmacologic or surgical means of weight loss therapy if behavioral programs are not successful.
  9. Pharmacology, use and side effects of weight loss medications, both prescription and non-prescription.
  10. Counseling of patients regarding the nutritional and medical risks associated with rapid weight loss (particularly that mediated by surgical intervention) that may impact CVD, including iron and B12 deficiency anemia, folate deficiency, as well as the potential for other deficiencies, including vitamin D and other fat soluble vitamins. Knowledge that physical fitness should be optimized prior to any drastic means of weight loss.

16. Exercise Physiology, Physical Activity Management, and Cardiac Rehabilitation (Secondary Prevention)

16.1. Justification

Important goals of exercise-based cardiac rehabilitation are to stabilize existing atherosclerotic plaques, improve endothelial function and lessen arterial inflammation by modulating lipid/lipoprotein levels and blood pressure, and achieve smoking cessation, if appropriate (169, 170). Additional objectives are to: increase functional capacity, decrease symptoms, reduce body weight and fat stores, promote psychosocial well-being, and improve the ability of the patient to return to work (171, 172). Recent meta-analyses indicate that exercise-based cardiac rehabilitation improves the cardiovascular risk factor profile and reduces all-cause and cardiovascular mortality, and that these benefits persist in the current era of cardiovascular therapeutics (173).

In the past, only post-MI patients were considered candidates for exercise-based cardiac rehabilitation. However, the proven benefits and safety of this intervention have expanded to include patients with angina, diabetes or metabolic syndrome, cardiomyopathy, pacemakers, heart valve replacement, concomitant pulmonary disease, cardiac transplant, and HF, as well as patients who have undergone percutaneous coronary intervention or coronary artery bypass graft surgery (170, 171, 174), yet these diagnoses are not all covered by health insurance.

Moderate-to-vigorous physical activity and improved cardiorespiratory fitness reduce cardiovascular-associated morbidity and mortality by multiple mechanisms (168, 174), including antiatherosclerotic, anti-ischemic, antiarrhythmic, and antithrombotic effects. Each 1 metabolic equivalent (MET), (1 MET = 3.5 mL O2/kg/min) increase in exercise capacity appears to confer an 8% to 17% reduction in mortality (175). Alternatively, an approximate 1,000-kcal/week increase in activity confers the equivalent survival benefit that would accrue by increasing cardiorespiratory fitness by 1 MET (176). Exercise testing may be helpful in quantifying aerobic capacity and in establishing a safe and effective exercise prescription (177, 178).

16.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. Prescription of exercise in primary prevention populations.
  2. Evaluation, appropriate interventions, and expected outcomes for each of the core components of contemporary cardiac rehabilitation/secondary prevention programs, including exercise training, risk factor modification, medical surveillance/emergency support, and psychosocial (e.g., stress management)/vocational counseling (179); as well as alternative delivery sources (e.g., site-supervised versus home-based [telephone, Internet, completion of exercise logs] programs) (170).
  3. ACC/AHA current guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease, including smoking cessation, blood pressure control, lipid management, physical activity, weight management, diabetes management, antiplatelet agents/anticoagulants, renin-angiotensin-aldosterone system blockers, beta blockers, and influenza vaccination (17).
  4. Multidisciplinary team approach to implementing an effective cardiac rehabilitation/secondary prevention program (179, 180).
  5. Traits, emotional states, and life situations that have been linked to CVD; for example, depression, anxiety, anger/hostility, social isolation, vital exhaustion, and chronic life stresses.
  6. Stages of behavior change and the concept of motivational interviewing to enable patients to favorably modify long-standing, deleterious lifestyle habits.
  7. Administration and interpretation of exercise tests as per the ACC/AHA 2000 Clinical Competence Statement on Stress Testing (178), with specific reference to the following variables: indications and contraindications; test endpoints; peak or maximal oxygen uptake; hemodynamics; rating of perceived exertion; recognition of supraventricular and ventricular arrhythmias; and interpretation of ST-segment displacement (175, 177, 178, 181). Competence includes the knowledge and skills required for certification in American Heart Association Basic and Advanced Life Support.
  8. Use of exercise test results for activity counseling and exercise prescription (175, 177, 181).
  9. Inverse relationship between physical activity and/or cardiorespiratory fitness, expressed as mL O2/kg/min or METs, and cardiovascular and all-cause mortality in persons with and without known CAD (168, 175, 176).
  10. Safety, benefits, rationale for and contraindications to endurance training and resistance exercise in primary and secondary prevention programs (175, 177, 181, 182).
  11. Basic terminology and fundamentals of exercise physiology, with specific reference to the interpretation of clinical exercise testing and the prescription of exercise in health and disease (175, 177, 181).
  12. Spectrum of cardiovascular conditions among patients who require physical activity counseling and/or might benefit from exercise training, including pathophysiology, signs and symptoms of stable and unstable disease, and medical and surgical treatments for the following conditions: CAD, including recent MI, post-percutaneous coronary intervention and post-coronary artery bypass grafting; cardiomyopathy and HF; valvular heart disease; peripheral arterial disease; hypertension; cardiac arrhythmia; and cardiac transplantation.
  13. The role of orthostatic/gravitational stress (e.g., intermittent sitting/standing) in preventing deconditioning during the hospital confinement period and early convalescence after an acute coronary event or intervention (183).
  14. Prescription of exercise (175, 177, 181), with respect to the intensity (e.g., threshold or minimal effective dosage) (184), frequency, duration, and modes of endurance exercise training, as well as lifestyle physical activity (185) and appropriate tracking modalities (e.g., pedometers) with specific reference to those patients with cardiovascular conditions as listed above.
  15. Co-morbidities and how they might affect exercise prescription and performance. This is especially important in diabetes mellitus, chronic pulmonary disease, and dialysis-dependant chronic kidney disease.
  16. Application of the elements of risk stratification (e.g., ejection fraction, signs/symptoms of myocardial ischemia, cardiorespiratory fitness) in triaging coronary patients to varied degrees of monitored/supervised exercise-based rehabilitation programs (170172).
  17. Variables that influence a patient's participation in and adherence to an exercise-based cardiac rehabilitation program (170), including the importance of physician support and encouragement (180).
  18. Selected high-intensity, anaerobic-type domestic, occupational or recreational activities (e.g., running, racquet sports, snow removal) may pose an increased risk of acute cardiovascular events, especially in habitually sedentary persons with known or occult CAD (186).
  19. The role that physical activity plays as primary prevention for CVD as a public health measure.

17. Pre-diabetes, Metabolic Syndrome, Insulin Resistance, and Diabetes Management

17.1. Justification

There are very strong epidemiological data available to support the concept that type 2 diabetes is associated with greatly increased risk of cardiovascular events. In addition, patients with type 1 diabetes of long duration, with other complications, are also at risk for cardiovascular events. Several clinical trials have assessed the effect of glycemic control on long-term microvascular complications, including CVD. Good glycemic control utilizing effective insulin regimens in type 1 diabetes may prevent CVD and trials of the effect of intensive therapy on CVD in type 2 diabetes are in progress. The metabolic syndrome, pre-diabetes, and insulin resistance, also portend an elevated risk of cardiovascular disease.

17.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

  1. The understanding of molecular and cellular mechanisms of impaired glucose tolerance, hyperinsulinemia, metabolic syndrome and overt diabetes.
  2. Methods of cardiovascular risk assessment in diabetic patients including risk engines and other tools developed to assess cardiovascular risk in patients with type 2 diabetes.
  3. Adherence and disease outcome interdisciplinary programs that meet the educational standards, recommended by the American Diabetes Association (ADA). Such programs may be effectively integrated with weight management programs and other risk factor management education strategies.
  4. Principles of diabetes management, both behavioral and pharmacological, and multiple resources which are available from organizations such as the ADA/AACE that are available on web sites for both patients and health care professionals.
  5. Criteria for effective screening and diagnosis of pre-diabetes, insulin resistance, and metabolic syndrome (187), including the several definitions for the metabolic syndrome that have been recommended.
  6. Identification of patients at risk for type 2 diabetes, understanding treatment and when to refer to a specialist. Management of pre-diabetes consists of lifestyle changes (188).
  7. Management of overt diabetes, including the goals for metabolic control standards of care for people with diabetes, including essential clinical and laboratory tests and requirements for screening for complications, and individualized pharmacological therapy that are regularly published and updated by the ADA and other organizations (189).
  8. Implementation of guidelines regarding maintenance of normoglycemia in the ICU setting (190).

18. Chronic Disease Management

18.1. Justification

Patient-specific and systems approaches to the primary and secondary prevention of CVD are essential for optimal atherosclerosis disease management (191193). This type of approach must encompass a simple and meaningful strategy for both patient and provider throughout the process of risk assessment and intervention (medication management and lifestyle modification) (194). Guidelines are based on the results of randomized trials (17).

Too often providers forget to implement the standard guidelines that deal with antiplatelet therapy, antihypertensive therapy, lipid lowering therapy, and lifestyle changes; all of these items are important in improving the quality of medical care. As a profession, we need to improve the frequency with which evidence-based guidelines are applied in clinical practice. Many guidelines have been published but there has been a disappointing lack of standard implementation.

Basic physician education and passive dissemination of guidelines alone are generally insufficient to sustain quality improvement. Chart audit and feedback of results, reminder systems to consider use of specific medicines or tests, and the use of local opinion leaders have had variable results. Multifactorial interventions that simultaneously attack different barriers to change tend to be more successful than isolated efforts. Dissemination of practice guidelines and knowledge of cardiovascular prevention must be accompanied by more intensive educational and behavioral interventions to maximize the chances of improving physician practice patterns.

The AHA has endorsed the Get With the Guidelines approach and the ACCF has endorsed an approach to the management of chronic stable angina and the prevention of CVD in general (192, 195). These approaches should help medical practices and the individual patient better understand the various pharmacologic therapies available for a given individual condition.

The ACCF Guidelines Applied in Practice (GAP) Program is also a well conceived systems approach that has been focused on patients presenting with acute coronary syndromes (196198). The same principles of prompt initiation of antiplatelet therapy, beta blockade, inhibition of the renin-aldosterone-angiotensin system, cholesterol lowering therapy, and better dietary and exercise habits can also be modified for use in chronic management of persons with atherosclerotic vascular disease (199201).

18.2. Minimal Knowledge

The expert in the prevention of cardiovascular disease should demonstrate knowledge and competence in:

Existing patient specific, systems approaches to prevention of CVD including:

  1. The implementation of the AHA's Get With The Guidelines (GWTG).
  2. Chronic disease management programs specific to CV disease.
  3. The basics of the chronic care model applied to CVD prevention (202204).
  4. Understanding of current performance measures for primary and secondary prevention of cardiovascular disease in all practice settings.
  5. Implementation of performance improvement measures.

APPENDIX 1. AUTHOR RELATIONSHIPS WITH INDUSTRY AND OTHER ENTITIES—ACCF/AHA/ACP 2009 COMPETENCE AND TRAINING STATEMENT: A CURRICULUM ON PREVENTION OF CARDIOVASCULAR DISEASE

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APPENDIX II. REVIEWER RELATIONSHIPS WITH INDUSTRY AND OTHER ENTITIES—ACCF/AHA/ACP 2009 COMPETENCE AND TRAINING STATEMENT: A CURRICULUM ON PREVENTION OF CARDIOVASCULAR DISEASE

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Footnotes

This document was approved by the American College of Cardiology Board of Trustees in October 2008, and by the American Heart Association Science Advisory and Coordinating Committee in November 2008, and by the American College of Physicians in April 2009.

The American College of Cardiology Foundation requests that this document be cited as follows: Bairez Merz CN, Alberts MJ, Balady GJ, Ballantyne CM, Berra K, Black HR, Blumenthal RS, Davidson MH, Fazio SB, Ferdinand KC, Fine LJ, Fonseca V, Franklin BA, McBride PE, Mensah GA, Merli GJ, O'Gara PT, Thompson PD, Underberg JA. ACCF/AHA/ACP competence and training statement: a curriculum on prevention of cardiovascular disease: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence (ACC/AHA/ACP Committee on Prevention of Cardiovascular Disease); J Am Coll Cardiol 2009;VOL:page-page.

Copies: This document is available on the World Wide Web sites of the American College of Cardiology (www.acc.org), and the American Heart Association (www.americanheart.org). For copies of this document, please contact Elsevier Inc. Reprint Department, fax (212) 633-3820, moc.reivesle@stnirper.

Permissions: Modification, alteration, enhancement, and/or distribution of this document are not permitted without the express permission of the American College of Cardiology Foundation. Please contact Elsevier's permission department at moc.reivesle@snoissimrephtlaeh.

Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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