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From:
Published online 2009 September 9. doi: 10.1208/s12248-009-9140-1

Table I

Selected Examples of Local Delivery of siRNA Using Lipidic Systems

Delivery routeDiseaseTarget geneDelivery systemDose of siRNAAnimal modelReferences
IntraocularIschemic retinopathyHIF-1αDharmaconTM transfection reagent~1.4 mgRats(89)
Synaptic activity in Alzheimer’s diseaseAmyloid precursor proteinTransMessengerTM transfection reagent1 μgRats(90)
Ocular neovascularizationVEGFLipofectamineTM ~1.3 μgRats(91)
Ocular inflammation and fibrosisTGF-βTransIT-TKOTM ~80 ngMouse(92)
IntranasalPulmonary inflammationeIF5ADOTAP transfecting reagent50 μgMouse(93)
Equine herpesvirus type 1 (EHV-1) infectionOri and glycoprotein BLipofectamineTM or naked siRNA~0.5 μgMouse(94)
Respiratory syncytial/parainfluenza virusRSV-P and HPIV3-PTransIT-TKOTM or Naked siRNA70 μgMouse(22)
Influenza A virus infectionNucleoprotein or acidic polymeraseOligofectamineTM ~20 μgMouse(95)
Respiratory syncytial virusRSV/A2Lipidoid2 mg/kgMouse(56)
IntratrachealLung inflammation diseasesP38 MAP kinaseCholesterol conjugation~133 μgMouse(96)
IntracerebralPost-ischemic cerebral inflammationSTAT3OligofectamineTM ~11 μgRats(97)
Huntingtin diseaseHttCholesterol conjugation~0.27 μgMouse(98)
IntrathecalPhrenic long-term facilitationBNDFOligofectamineTM ~11.3 μgRat(99)
Morphine-induced thermal hyperalgesiaRaf-1i-FectTM 2 μgRats(100)
PainNTS-2i-FectTM 1.25 μgRats(101)
Topical applicationWound healingMapk-1 and lamin A/CLipofectamine 2000 TM in agarose matrix~0.27 μgMouse(102)
TransdermalCutaneous melanocytic lesionB-Raf and AKT3PEGylated DOTAP liposomes / ultrasound25 μgMouse(103)
IntravaginalHerpes simplex virus 2 infectionHSV-2OligofectamineTM ~6.7 μgMouse(104)
Herpes simplex virus 2 infectionHSV-2Cholesterol conjugation~26 μgMouse(24)
IntrarectalColitisTNF-αLipofectamineTM ~53 μgMouse(23)
IntratumoralProstate cancer bone metastasisIntegrin α5PEGylated cationic liposomes1 μgMouse(11)
Nasopharyngeal cancerHer-2Folate targeted PEGylated cholesterol-containing NP10 μgMouse(12)
Ovarian cancerClaudin-3PEGylated cationic lipid particles25 μgMouse(13)
Lung cancerS1P receptor 1DOTAP liposomes15 μgMouse(14)
Breast cancerRhoACytofectinTM ~110 ngMouse(15)