Where inhibition of singular nodes fails, pre-treatment with a combination therapy sensitizes Huh7 cells to 17AAG, and works as well or better than 17AAG in all cell lines tested. A Double positive populations of Huh7 cells (mean of triplicate+/−SEM as gated in 1A) in response to different treatments at 48hours. The IKK inhibitor is BMS-345541 and was used at 15uM, the PI3K inhibitor is PI103 and was used at 5µM, the JAK inhibitor is Calbiochem JAK inhibitor 1: Pyridone 6, and was used at 3µM. The P-values were obtained by a T-test B The double-positive populations for the listed treatments of Hep3B and FOCUS cells (mean of triplicates +/−SEM) at 48 hours. The P-values were obtained by a T-test. The drug combination is the same as in A.