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From:
Published online 2009 October 21. doi: 10.1007/s12079-009-0077-z

Table 1

Summary of TSP-associated tissue repair phenotypes

ModelTSP1 KOTSP2 KOTSP1/TSP2 Double KO
Wound healingProlonged inflammationEnhanced angiogenesisProlonged inflammation
Delayed wound closure, delayed scab loss and reepithelializationAccelerated wound closureDelayed wound closure, delayed scab loss and reepithelialization
Normal angiogenesisIrregular ECM assemblyNormal angiogenesis
Altered granulation tissue morphologyIncreased MMP-2 and MMP-9Altered granulation tissue morphology
Decreased MCP-1Increased soluble VEGFDecreased MCP-1
Decreased TGF-β (total and active)Decreased TGF-β (total and active)
Hindlimb ischemiaEnhanced angiogenesisEnhanced angiogenesisEnhanced angiogenesis
Enhanced blood flow recoveryEnhanced blood flow recoveryIncreased platelet-derived SDF-1
Involves NO signalingIncreased baseline arteriogenesis
Macrophage-dependentIncreased MMP-9
Skin FlapIncreased survivalNormalNormal
Involves CD47 and NO signaling
Polyninyl alcohol sponge ImplantationNot determinedEnhanced angiogenesisNot determined
Increased MMP-2, NC TGF-β
Increased encapsulation
Irregular ECM assembly
Decreased invasion
Brain: Increased neuroinflammation and BBB permeability
Increased MMP-2 and MMP-9
Foreign body responseNot determinedEnhanced angiogenesisNot determined
Increased MMP-2
Increased encapsulation
Irregular ECM assembly