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J Diabetes Sci Technol. 2008 May; 2(3): 509–517.
Published online 2008 May. doi:  10.1177/193229680800200324
PMCID: PMC2769746

Diabetes Self-Management Care via Cell Phone: A Systematic Review

Santosh Krishna, Ph.D., Ed.S.1 and Suzanne Austin Boren, Ph.D., M.H.A.2,3,4



The objective of this study was to evaluate the evidence on the impact of cell phone interventions for persons with diabetes and/or obesity in improving health outcomes and/or processes of care for persons with diabetes and/or obesity.


We searched Medline (1966–2007) and reviewed reference lists from included studies and relevant reviews to identify additional studies. We extracted descriptions of the study design, sample size, patient age, duration of study, technology, educational content and delivery environment, intervention and control groups, process and outcome measures, and statistical significance.


In this review, we included 20 articles, representing 18 studies, evaluating the use of a cell phone for health information for persons with diabetes or obesity. Thirteen of 18 studies measured health outcomes and the remaining 5 studies evaluated processes of care. Outcomes were grouped into learning, behavior change, clinical improvement, and improved health status. Nine out of 10 studies that measured hemoglobin A1c reported significant improvement among those receiving education and care support. Cell phone and text message interventions increased patient–provider and parent–child communication and satisfaction with care.


Providing care and support with cell phones and text message interventions can improve clinically relevant diabetes-related health outcomes by increasing knowledge and self-efficacy to carry out self-management behaviors.

Keywords: cellular phone, diabetes mellitus, outcomes of care, process of care randomized controlled trials, SMS, text messaging, wireless

It is an ongoing challenge to provide care and support that will produce and sustain the desired improvements in the health of persons with a chronic illness such as diabetes. Quality health care requires effective collaboration between clinicians and patients.1,2 Finding novel ways to enhance communication and improve the health of those with chronic diseases is also a continuing part of providing care. Interventions involving automated telephone message systems have been shown to improve knowledge and health outcomes.35 Telephone-based interventions have had positive results even among persons of low socioeconomic status and ethnic minorities.6

According to the Cellular Telecommunications and Internet Association, there are over 255 million cell phone subscribers in the United States.7 Although income may seem to be a major barrier in cell phone ownership, every two out of three households in the United States have a cell phone.8 In a survey of those owning a cell phone, 35% said that they use it for text messaging.9 There is a need to examine if the various functions of cell phones, including text messaging, can help with providing better health care and lead to improved health outcomes.

Education and information technology are parts of diabetes care that have been studied. There are other reviews on health care telephone technology,10,11 automated telephone messages,4,12 cell phone technology,13 diabetes Web-assisted interventions,14 and diabetes-computerized learning technologies.15 However, no systematic review or meta-analysis of cell phone-based interventions for persons with diabetes and/or obesity exists to our knowledge that analyzes the evidence on the use of cell phones and text messaging interventions to improve health outcomes, processes of care, acceptance by users, and whether it is cost-effective.

The objective of this study was to evaluate the evidence on the impact of cell phone interventions in improving health outcomes and/or processes of care for persons with diabetes and/or obesity. We systematically reviewed studies to evaluate the impact of care and support interventions via cell phone in improving health outcomes and processes of care for persons with diabetes and/or obesity.


Data Sources

We searched Medline (1966–2007) for eligible trials using combinations of the following search terms: (1) diabetes mellitus (medical subject headings (MeSH)), type 1 diabetes mellitus (MeSH), type 2 diabetes mellitus (MeSH), or obesity (MeSH); (2) telephone (MeSH), cellular phone (MeSH), handheld computers (MeSH), cell phones, mobile phones, text messages, short message service (SMS), or personal digital assistants (PDA); and (3) patient education as topic (MeSH), health education (MeSH), patient education, or health education. We also systematically searched the reference lists of included studies and relevant reviews.

Study Selection and Data Extraction

The investigators reviewed the titles and abstracts of the identified citations and identified eligible articles based on the following criteria. Inclusion criteria included any randomized controlled trial, quasi-experimental study, or pre–post study evaluating the use of cell phones for health information for persons with diabetes and/or obesity. The included studies measured health outcomes or processes of care. Studies published in a language other than English with a complete English abstract were included if they met the specified inclusion criteria. The investigators collected the following information from each article that was eligible: descriptions of the study design, country, sample size, patient age, duration of study, technology, frequency, intervention and control groups, educational content and delivery, process and outcome measures, and statistical significance.


Comprehensive literature searches identified 51 articles. The titles and abstracts of these articles were read, and 26 articles were determined to be potentially relevant. After reading the full articles, 20 articles representing 18 studies met the eligibility criteria. Articles were excluded if they did not focus on diabetes or obesity (8 articles), a cell phone or text messaging for health information or education was not used (15 articles), or health outcomes or processes of care were not measured (8 articles) (Tables 1 and 22).

Table 1.
Cell Phone Interventions and Health Outcomes
Table 2.
Cell Phone Interventions and Process of Care

The final set of 18 studies included 1176 participants, with 6 studies involving 221 children and 12 involving 955 adults. Sample sizes ranged from 7 to 274 participants for adult studies and 11 to 92 participants for studies involving children. Three studies enrolled more than 130 participants.

Study duration ranged from 3 to 12 months, with the exception of one study lasting for the duration of a diabetes summer camp.31 Eight studies were of 3 months duration,17,2022,2527,35 two of 8 months duration,28,32 one of 4 months duration,33 and two of 6 months duration.23,29 Four of the selected studies were of 12 months' duration.16,18,30,34 In studies lasting more than 3 months, return visits for diabetes patients were scheduled for regular checkups and to obtain data for laboratory measurements.

Studies took place in nine different countries, including one in Austria,29 two in Japan,26,31 one in France,16 six in Korea,2025,27,30 two in Norway,33,35 one in Spain,32 one in Taiwan,28 two in the United Kingdom,18,34 and one in the United States.17

Education Content and Method

In addition to general information on diabetes17,18,27,31,32,35 or weight reduction,19,26 educational intervention and support in the studies were personalized to an individual care plan of the participants. Patients were requested to send information via voice mail or text message or at the Web site, which became the basis of personalized advice and support from the diabetes care team.16,17,19,26,27,29,32,33 Participants in diabetes studies, for example, were provided monitoring and advice based on individual blood sugar measurements, medications, insulin dose information, diet, weight, physical activities, and other information input by the participants as required by the study protocol. In providing personalized advice, health care providers also took into consideration patient history, such as age, years with diabetes, comorbidities, family history of diabetes, and laboratory results. Participants in studies focusing on weight reduction and management received personalized tips on diet and nutrition, how to overcome barriers, and how to maintain a regular physical activity program leading to weight reduction.19,26

As part of the intervention, patients also received reminders to perform diabetes self-management activities (e.g., check their blood sugar and feet,17,33 take medication,17 log-in and input information,25,30,34 complete assessment questionnaires,17,18,34 or review information on the next follow-up visit28). In two studies, motivational messages were sent to the intervention group participants for maintaining their exercise schedule and overcoming barriers to maintaining a healthy life style.19,26 The personalized messages were generated by algorithms based on data the patients input.

Technology of Intervention

Technology used to provide education and information interventions in all studies included cell phones and SMS. While the majority of studies utilized the text messaging feature of cell phones to provide tailored advice and support, in some studies,2226,30 patients had the option of using wireless or wired Internet to input their glucose measurements. One study sent reminders about the next appointment to the cell phone and via email.28 Another study also utilized PDAs.16 Only one study performed all interactions with study participants through technology-based communication and did not provide any face-to-face meeting opportunity during the study duration.26 Regardless of the mode of communication, all studies provided advice tailored to individual needs and the treatment regimen. Tables 3 and 44 provide the details of specific education and information provided.

Table 3.
Technology in Studies with Outcomes of Care
Table 4.
Technology in Studies with Process of Care

Studies with Health Outcomes

Outcomes of care were defined as changes in diabetes-related health outcomes because of an educational or informational intervention delivered through cell phones using voice or short message service. We grouped the outcome measures according to the diabetes self-management education core outcome measures continuum: learning, behavior change, clinical improvement, and improved health status.36 Table 1 lists studies that evaluated the impact of diabetes educational interventions on the control of blood sugar levels and other related health outcomes.


Two studies measured outcomes related to knowledge and skills.17,19 These outcomes included average knowledge scores as measured by the Diabetes Knowledge Test from The Michigan Diabetes Research and Training Center,17 as well as perceived control, internal control, external control, and intention related to exercise.19

Behavior Change

Behavior change was measured in five of the studies.1619,22 These measures included general measures of self-efficacy and adherence to behavioral change,18 as well as self-management behaviors such as blood glucose monitoring,16,17 taking medication,17,22 eating appropriately,22 physical activity,17,19,22 and foot care.17,22

Clinical Improvement

Thirteen studies measured clinical changes.1630 The clinical measures were related to hemoglobin A1c (10 studies),1618,2125,2730 blood glucose (7 studies),16,20,21,2325,27,28,30 cholesterol (5 studies),20,21,23,24,27,28,30 weight (3 studies),17,19,26 and blood pressure (1 study).19 Nine of the 10 studies that measured hemoglobin A1c observed a significant improvement. The results regarding blood glucose, cholesterol, and weight were mixed, while the results for blood pressure were nonsignificant.

Health Status

Two studies measured health status outcomes.16,17 Quality of life was determined using the Diabetes Quality of Life questionnaire and satisfaction with life was also measured.16 Diabetes complications were measured as hypoglycemic symptoms16,17 and hyperglycemic symptoms.17

Studies with Processes of Care

Table 2 lists studies that evaluated the impact of educational intervention on the process of diabetes care.3135 In addition, three studies that measured diabetes-related health outcomes also measured process of care.17,26,28 The processes of care commonly measured included system convenience or ease of use,17,26,31,33,35 system usage,28,32 satisfaction with the system,31,32,34,35 time to use the system,17 or running costs.32 The processes of care measures were generally favorable to cell phone use. Unfortunately, the diversity of process measures used made it impossible to provide a summary of significant results from process measures beyond what is shown in Table 2.


The purpose of this review was to evaluate the contribution of cell phone interventions in the control and management of diabetes. In this review, most studies provided standard diabetes care utilizing face-to-face communication during clinic visits. In addition, the intervention group participants received care through cell phones using one or more of their functional aspects (e.g., SMS, voice mail, Internet, or email). Cell phones were used as a management tool to enable information to flow between patients and providers. In a chronic disease such as diabetes, maintaining blood sugar levels and related clinical and physiological measurements to acceptable levels requires monitoring and management through regular self-care behaviors. In some studies, cell phones and text messaging facilitated regular treatment advice and support in between clinic visits. In other studies, cell phones and text messaging proved to be good tools to deliver regular alerts and reminders to achieve desired goals. Nine out of 10 studies that used cell phone technology and measured hemoglobin A1c showed significant decreases in hemoglobin A1c values. Results of our study indicate that educational interventions providing personalized advice and support delivered through a cell phone can help avoid diabetes symptoms by providing timely treatment adjustments and can lead to improved health outcomes.

The concept of using interactive voice mail messages to deliver information or education in disease management and control is not new.37 Computer and communication technology-based education and support are becoming vital components of quality diabetes care.38 Diabetes education and diabetes management support through automated telephone reminders and support have been shown to increase knowledge, increase frequency of self-care behaviors among persons with diabetes, and improve health outcomes for patients who need regular care and monitoring and self-care management.39 Because monitoring and support from a health care provider play important roles in achieving the desired clinical goals, the use of cell phones, especially text messaging, is a step further in achieving the health and quality of life for persons with diabetes. Using cell phones and text messaging offers great opportunities to improve patient self-management by facilitating education, monitoring, and feedback between scheduled clinic visits. The ubiquitous nature of cell phones provides the mobility and flexibility so that care can be provided wherever a patient may be.40 A potential implication of this is licensure issues if a health care provider is licensed in one state and the patient is receiving treatment in another state. As more and more people own cell phones, text messaging may even provide cost-effective alternatives to regular phone communication when combined with other methods of education and support.41,42 Unfortunately, only one study in this review provided information on the costs of running the system.32

Results of this systematic review should be interpreted with limitations in mind. The studies did not provide the reliability and validity of the information that patients entered into the cell phones; however, two studies provided examples of how a automated system could be programmed to check if the value entered was within a predefined range.16,17 The heterogeneity of the studies prevented a meta-analysis, which could have allowed for a quantitative assessment. We attempted to search comprehensively; however, we may have unknowingly left out some work that was eligible for inclusion. Regardless, the benefits offered or limitations involved in the use of cell phones in diabetes care are estimated to be the same.


Medical Subject Headings
personal digital assistants
short message service


1. Institute of Medicine, Committee on Quality of Health Care in America. Washington, DC: National Academy Press; 2001. Crossing the quality chasm: a new health system for the 21st century. [PubMed]
2. Wagner EH, Austin B, Von Korff M. Improving outcomes in chronic illness. Manag Care Q. 1996;4(2):12–25. [PubMed]
3. Krishna S, Balas EA, Boren SA, Maglaveras N. Patient acceptance of educational voice messages: a review of controlled clinical studies. Methods Inf Med. 2002;41(5):360–369. [PubMed]
4. Piette JD, Weinberger M, McPhee SJ, Mah CA, Kraemer FB, Crapo LM. Do automated calls with nurse follow-up improve self-care and glycemic control among vulnerable patients with diabetes? Am J Med. 2000;108(1):20–27. [PubMed]
5. Piette JD, Weinberger M, Kraemer FB, McPhee SJ. Impact of automated calls with nurse follow-up on diabetes treatment outcomes in a Department Of Veterans Affairs Health Care System: a randomized controiied trial. Diabetes Care. 2001;24(2):202–208. [PubMed]
6. Albright CL, Pruitt L, Castro C, Gonzalez A, Woo S, King AC. Modifying physical activity in a multiethnic sample of low-income women: one-year results from the IMPACT (Increasing Motivation for Physical ACTivity) project. Ann Behav Med. 2005;30(3):191–200. [PubMed]
7. CTIA Cellular Telecommunications and Internet Association. [cited 2008 Mar 3]. Available from:
8. Rice RE, Katz JE. Comparing internet and mobile phone usage. Telecomm Policy. 2003;27(8-9):597–623.
9. Pew Internet & American life project [cited 2008 Jan 20]. Available from:
10. Balas EA, Jaffrey F, Kuperman GJ, Boren SA, Brown GD, Pinciroli F, Mitchell JA. Electronic communication with patients. Evaluation of distance medicine technology. JAMA. 1997;278(2):152–159. [PubMed]
11. McBride CM, Rimer BK. Using the telephone to improve health behavior and health service delivery. Patient Educ Couns. 1999;37(1):3–18. [PubMed]
12. Biem H, Jay MD, Turnell RW, D'Arcy C. Computer telephony: automated calls for medical care. Clin Invest Med. 2003;26(5):259–268. [PubMed]
13. Kaplan WA. Can the ubiquitous power of mobile phones be used to improve health outcomes in developing countries? Global Health. 2006;2:9. [PMC free article] [PubMed]
14. Brown LL, Lustria ML, Rankins J. A review of web-assisted interventions for diabetes management: maximizing the potential for improving health outcomes. J Diabetes Sci Technol. 2007;1(6):892–902. [PMC free article] [PubMed]
15. Boren SA, Gunlock TL, Peeples MM, Krishna S. Computerized learning technologies for diabetes: a systematic review. J Diabetes Sci Technol. 2008;2(1):139–146. [PMC free article] [PubMed]
16. Benhamou PY, Melki V, Boizel R, Perreal F, Quesada JL, Bessieres-Lacombe S, Bosson JL, Halimi S, Hanaire H. One-year efficacy and safety of Web-based follow-up using cellular phone in type 1 diabetic patients under insulin pump therapy: the PumpNet study. Diabetes Metab. 2007;33(3):220–226. [PubMed]
17. Durso SC, Wendel I, Letzt AM, Lefkowitz J, Kaseman DF, Seifert RF. Older adults using cellular telephones for diabetes management: a pilot study. Medsurg Nurs. 2003;12(5):313–317. [PubMed]
18. Franklin VL, Waller A, Pagliari C, Greene SA. A randomized controlled trial of Sweet Talk, a text-messaging system to support young people with diabetes. Diabet Med. 2006;23(12):1332–1338. [PubMed]
19. Hurling R, Catt M, Boni MD, Fairley BW, Hurst T, Murray P, Richardson A, Sodhi JS. Using internet and mobile phone technology to deliver an automated physical activity program: randomized controlled trial. J Med Internet Res. 2007;9(2):e7. [PMC free article] [PubMed]
20. Kim HS, Yoo YS, Shim HS. Effects of an Internet-based intervention on plasma glucose levels in patients with type 2 diabetes. J Nurs Care Qual. 2005;20(4):335–340. [PubMed]
21. Kim HS. Effects of Web-based diabetic education in obese diabetic patients. Taehan Kanho Hakhoe Chi. 2005;35(5):924–930. [PubMed]
22. Kim HS, Kim NC, Ahn SH. Impact of a nurse short message service intervention for patients with diabetes. J Nurs Care Qual. 2006;21(3):266–271. [PubMed]
23. Kim HS. A randomized controlled trial of a nurse short-message service by cellular phone for people with diabetes. Int J Nurs Stud. 2007;44(5):687–692. [PubMed]
24. Kim HS. Impact of Web-based nurse's education on glycosylated haemoglobin in type 2 diabetic patients. J Clin Nurs. 2007;16(7):1361–1366. [PubMed]
25. Kim HS, Jeong HS. A nurse short message service by cellular phone in type-2 diabetic patients for six months. J Clin Nurs. 2007;16(6):1082–1087. [PubMed]
26. Kubota A, Fujita M, Hatano Y. Development and effects of a health promotion program utilizing the mail function of mobile phones. Nippon Koshu Eisei Zasshi. 2004;51(10):862–873. [PubMed]
27. Kwon HS, Cho JH, Kim HS, Lee JH, Song BR, Oh JA, Han JH, Kim HS, Cha BY, Lee KW, Son HY, Kang SK, Lee WC, Yoon KH. Development of web-based diabetic patient management system using short message service (SMS) Diabetes Res Clin Pract. 2004;66(Suppl 1):S133–S137. [PubMed]
28. Liu CT, Yeh YT, Lee TI, Li YC. Observations on online services for diabetes management. Diabetes Care. 2005;28(11):2807–2808. [PubMed]
29. Rami B, Popow C, Horn W, Waldhoer T, Schober E. Telemedical support to improve glycemic control in adolescents with type 1 diabetes mellitus. Eur J Pediatr. 2006;165(10):701–705. [PubMed]
30. Yoon KH, Kim HS. A short message service by cellular phone in type 2 diabetic patients for 12 months. Diab Res Clin Prac. 2008;79(2):256–261. [PubMed]
31. Aoki N, Ohta S, Okada T, Oishi M, Fukui T. INSULOT: a cellular phone-based edutainment learning tool for children with type 1 diabetes. Diabetes Care. 2005;28(3):760. [PubMed]
32. Ferrer-Roca O, Cardenas A, Diaz-Cardama A, Pulido P. Mobile phone text messaging in the management of diabetes. J Telemed Telecare. 2004;10(5):282–285. [PubMed]
33. Gammon D, Arsand E, Walseth OA, Andersson N, Jenssen M, Taylor T. Parent-child interaction using a mobile and wireless system for blood glucose monitoring. J Med Inter Res. 2005;7(5):e57. [PMC free article] [PubMed]
34. Tasker AP, Gibson L, Franklin V, Gregor P, Greene S. What is the frequency of symptomatic mild hypoglycemia in type 1 diabetes in the young?: assessment by novel mobile phone technology and computer-based interviewing. Pediatr Diabetes. 2007;8(1):15–20. [PubMed]
35. Wangberg SC, Arsand E, Andersson N. Diabetes education via mobile text messaging. J Telemed Telecare. 2006;12(Suppl 1):55–56. [PubMed]
36. Mulcahy K, Maryniuk M, Peeples M, Peyrot M, Tomky D, Weaver T, Yarborough P. Diabetes self-management education core outcomes measures. Diabetes Educ. 2003;29(5):768–803. [PubMed]
37. Krishna S, Balas EA, Spencer DC, Griffin JZ, Boren SA. Clinical trials of interactive computerized patient education: implications for family practice. J Fam Pract. 45(1):25–33. [PubMed]
38. Balas EA, Krishna S, Kretschmer RA, Cheek TR, Lobach DF, Boren SA. Computerized knowledge management in diabetes care. Med Care. 2004;42(6):610–621. [PubMed]
39. Boren SA, De Leo G, Chanetsa FF, Donaldson J, Krishna S, Balas EA. Evaluation of a Diabetes Education Call Center intervention. Telemed J E Health. 2006;12(4):457–465. [PubMed]
40. Boland P. The emerging role of cell phone technology in ambulatory care. J Ambul Care Manage. 2007;30(2):126–133. [PubMed]
41. Gimenez-Perez G, Gallach M, Acera E, Prieto A, Carro O, Ortega E, González-Clemente JM, Mauricio D. Evaluation of accessibility and use of new communication technologies in patients with type 1 diabetes mellitus. J Med Internet Res. 2002;4(3):E16. [PMC free article] [PubMed]
42. Leong KC, Chen WS, Leong KW, Mastura I, Mimi O, Sheikh MA, Zailinawati AH, Ng CJ, Phua KL, Teng CL. The use of text messaging to improve attendance in primary care: a randomised controlled trial. Fam Pract. 2006;23(6):699–705. [PubMed]

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