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AAPS PharmSci. Sep 2000; 2(3): 38–44.
Published online Jul 27, 2000. doi:  10.1208/ps020323
PMCID: PMC2761134
Recovery of human skin impedance in vivo after lontophoresis: Effect of metal ions
Catherine Curdy,1,2,3 Yogeshvar N. Kalia,1,2,3 and Richard H. Guycorresponding author1,2,3
1Centre Interuniversitaire de recherche et d'Enseignement, Pharmapeptides, Campus Universitaire, Parc d'Affaires International, F-74166 Archamps, France
2Faculté des Sciences-Section de Pharmacie. Laboratoire de Pharmacie Galénique, Université de Genève, Ch-1211 Genève 4, Switzerland
3Faculté de Pharmacie, Institut des Sciences Pharmaceutiques et Biologiques, Université Claude Bernard, F-69373 Lyon 1, France
Catherine Curdy, curdy/at/pharmal.cur-archamps.fr.
corresponding authorCorresponding author.
Received March 23, 2000; Accepted July 3, 2000.
The objective of this study was to investigate the effect of the counter-ion (cation) on the recovery of human skin impedance after iontophoresis in vivo. A series of metal chloride aqueous solutions (NaCl, KCl, CaCl2, and MgCl2) was investigated: first at the same concentration (133 mmol/L) and then at the same ionic strength as a NaCl solution at 133 mmol/L. The influence of hydration alone was also examined as a control. The recovery of human skin impedance was followed in the frequency range 1–1,000 Hz, over a 30-minute period after iontophoresis during which 3 impedance spectra were recorded. The results revealed that at t=30 minutes post-iontophoresis, skin impedance was approximately 3 times greater than the value immediately after the cessation of current passage. However, the results showed that the nature of the cation had no effect on recovery, regardless of whether the ions were at the same concentration or at an equivalent ionic strength. A simple parallel RC-equivalent circuit model for skin was used to determine the resistive (R) and capacitive (C) contributions to skin impedance. An analysis of variance on the calculated R and C values did not show any differences between the electrolytes used at the 2 different ionic strengths.
Footnotes
published July 27, 2000
Contributor Information
Catherine Curdy, curdy/at/pharmal.cur-archamps.fr.
Yogeshvar N. Kalia, kalia/at/pharmal.curarchamps.fr.
Richard H. Guy, Phone: 33-0-3-50.31.50.21, Fax: 33-0-4-50.95.28.32, rhg/at/pharma1.cur-archamps.fr.
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